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Table 4 Fitting equations of relationships and correlation coefficients (r) of MDA levels (y) with the levels of GSH (x1) as well as the activity of SOD (x2) in the brain, liver, and kidneys of rats administered 0.5g and 1.0g of NiO-NPs (II and III), 0.5g and 1.0g of Co3O4-NPs (IV and V) as well as mixtures of NiO-NPs + Co3O4-NPs (0.25g + 0.25g, VI) and (0.5g + 0.5g, VII) per kilogram body weight, respectively

From: Genotoxicity and oxidative stress induced by the orally administered nanosized nickel and cobalt oxides in male albino rats

Variables   Experimental group
y x II III IV V VI VII
MDA levels (nmol/g tissue) GSH levels (mg/g tissue) Brain y = − 2.83x1 + 40.90
r = − 0.66**
y = − 1.21x1 + 29.14
r = − 0.89***
y = − 2.03x1 + 34.23
r = − 0.67**
y = − 0.99x1 + 29.08
r = − 0.50*
y = − 0.34x1 + 24.85
r = − 0.86***
y = − 1.27x1 + 30.90
r = − 0.87***
Liver y = − 3.37x1 + 67.23
r = − 0.57*
y = − 6.03x1 + 84.72
r = − 0.82***
y = − 5.84x1 + 82.31
r = − 0.70**
y = − 4.77x1 + 75.24
r = − 0.79***
y = − 4.83x1 + 73.73
r = − 0.69**
y = − 1.95x1 + 55.26
r = − 0.93***
Kidney y = − 9.58x1 + 110.03
r = − 0.90***
y = − 6.93x1 + 92.67
r = − 0.76***
y = − 4.96x1 + 79.58
r = − 0.65**
y = − 3.86x1 + 71.59
r = − 0.54*
y = − 6.81x1 + 90.49
r = − 0.82***
y = − 0.89x1 + 54.26
r = − 0.90***
SOD activity (U/g tissue) Brain y = − 0.67x2 + 5.93
r = − 0.82***
y = − 0.17x2 + 2.63
r = − 0.50*
y  = − 0.59x2 + 5.51
r = − 0.76***
y = − 0.18x2 + 2.90
r = − 0.50*
y = − 0.21x2 + 3.19
r = − 0.50*
y = − 0.14x2 + 2.99
r = − 0.82***
Liver y = − 0.08x2 + 0.99
r = − 0.68**
y = − 0.09x2 + 1.07
r = − 0.89***
y = − 0.08x2 + 0.95
r = − 0.71**
y = − 0.11x2 + 1.17
r = − 0.74**
y = − 0.07x2 + 0.89
r = − 0.79***
y = − 0.04x2 + 0.74
r = − 0.82***
kidney y = − 0.35x2 + 4.19
r = − 0.77***
y = − 0.51x2 + 5.45
r = − 0.76***
y = − 0.59x2 + 6.21
r = − 0.75***
y = − 0.23x2 + 3.58
r = − 0.80***
y = − 0.16x2 + 3.01
r = − 0.58*
y = − 0.12x2 + 2.99
r = − 0.70**
  1. *, **, ***: significant correlations between the studied variables at P<0.05, P<0.01 and P<0.001, respectively