Protective effect of theaflavin on glycoprotein components and TCA cycle enzymes in high-fat diet and streptozotocin-induced diabetic rats

The Journal of Basic and Applied Zoology

Table 1 Dose-dependent effect of theaflavin on blood glucose, insulin levels, and HOMA-IR index in control and experimental animals

Parameters	Control	Normal + theaflavin (100 mg/kg b.wt)	Diabetes	Diabetes + theaflavin (25 mg/kg b.wt)	Diabetes + theaflavin (50 mg/kg b.wt)	Diabetes + theaflavin 100 mg/kg b.wt	Diabetes + metformin (500 mg/kg b.wt)
Glucose (mg/dl)	97.65 ± 5.03	95.28 ± 5.15	273.76 ± 16.35^b	239.43 ± 12.54^c	183.98 ± 8.74^d	131.81 ± 7.49^e	129.64 ± 8.12
Insulin (μU/ml)	19.42 ± 1.80	18.99 ± 1.82	9.57 ± 1.18^b	11.80 ± 1.12^c	13.51 ± 1.36^d	16.15 ± 1.35^e	17.66 ± 1.27
HOMA-IR	4.68 ± 0.64	4.38 ± 0.53	6.62 ± 0.70^b	7.20 ± 0.81^c	60.2 ± 0.58^d	5.13 ± 0.37^e	5.57 ± 0.49

Values are given as mean ± SD for six animals in each group
Values are considered significantly different at P < 0.05 with post-hoc LSD test *P < 0.05
^aControl vs. drug control (theaflavin-alone-treated rats
^bControl rats vs. diabetic rats
^cDiabetic rats vs. theaflavin (25 mg/kg)
^dDiabetic rats vs. theaflavin (50 mg/kg)
^eDiabetic rats vs. theaflavin (100 mg/kg)
^fDiabetic rats treated with theaflavin (100 mg/kg) vs. diabetic rats treated with metformin (500 mg/kg)