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Fig. 9 | The Journal of Basic and Applied Zoology

Fig. 9

From: AiP1, a protein from the coelomic fluid of sea star Astropecten indicus promotes wound healing and fibrinogenolysis in vitro

Fig. 9

vWFA-like domain from the organism Strongylocentrotus purpuratus and its putative functional sites. A Multiple sequence alignment of “peptide1” and vWFA-like domain from the organisms Strongylocentrotus purpuratus (vWFA_SP; NCBI RefSeq accession numbers XP_780042.1) and Acanthaster planci (vWFA_AP; NCBI RefSeq accession numbers XP_022096018.1). The alignment was generated using CLUSTAL Omega version 1.2.4 (/www.ebi.ac.uk/Tools/msa/clustalo/). Predicted solvent accessible protein–protein interacting residues (predPPI) are highlighted (“b”). Solvent accessibility and PPI residues were predicted using NetSurfP (version 1.1, http://www.cbs.dtu.dk/services/NetSurfP/) and LORIS (Dhole, Singh, Pai, & Mondal, 2014), respectively. B Ribbon representation of the modeled vWFA_SP (5kyn_A as template with sequence identity 77.5%) generated using SwissModel (Bienert et al., 2017). Highlighted position (green, R286 to T309) on this model is identical with “peptide1.” C Predicted solvent accessible PPIs (predPPI) mapped on the modeled vWFA_SP. Figure B and C were generated using PyMol (version 2.2,https://pymol.org/)

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