Skip to main content

Table 2 Effect of l-carnitine on BDNF, COX-2, and PGE2 in the brain of male rats treated with aspartame

From: l-carnitine acts as a neuroprotecor against aspartame injury in Wistar albino rat

Parameters Control LC ASP-LD ASP-HD ASP-LD and LC ASP-HD and LC
BDNF (pg/mg tissue) 55.1 ± 1.7 57.5 ± 0.9 32.3 ± 0.8a 22.3 ± 0.7a,b 44.37 ± 1.6c 42.2 ± 0.7c
COX-2 (ng/mg tissue) 0.7 ± 0.1 0.8 ± 0.1 1.6 ± 0.1a 2.3 ± 0.1a,b 0.8 ± 0.1c 0.9 ± 0.1
PGE2 (pg/mg tissue) 13.1 ± 0.6 12.9 ± 0.6 23.8 ± 0.4a 29.1 ± 0.7a,b 16.7 ± 1.7c 18.2 ± 0.8
  1. Values are expressed as mean ± SE, n = 8
  2. LCl-carnitine, ASP-LD a low dose of aspartame, ASP-HD a high dose of aspartame, BDNF brain-derived neuroatrophic factor, COX-2 cyclooxygenase-2, PGE2 prostaglandin E2
  3. aSignificant difference as compared to control
  4. bSignificant difference as compared to ASP-LD
  5. cSignificant difference as compared to its relative group of ASP (P ≤ 0.05).