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The Journal of Basic and Applied Zoology

Table 2 Effect of l-carnitine on BDNF, COX-2, and PGE2 in the brain of male rats treated with aspartame

From: l-carnitine acts as a neuroprotecor against aspartame injury in Wistar albino rat

Parameters

Control

LC

ASP-LD

ASP-HD

ASP-LD and LC

ASP-HD and LC

BDNF (pg/mg tissue)

55.1 ± 1.7

57.5 ± 0.9

32.3 ± 0.8a

22.3 ± 0.7a,b

44.37 ± 1.6c

42.2 ± 0.7c

COX-2 (ng/mg tissue)

0.7 ± 0.1

0.8 ± 0.1

1.6 ± 0.1a

2.3 ± 0.1a,b

0.8 ± 0.1c

0.9 ± 0.1

PGE2 (pg/mg tissue)

13.1 ± 0.6

12.9 ± 0.6

23.8 ± 0.4a

29.1 ± 0.7a,b

16.7 ± 1.7c

18.2 ± 0.8

  1. Values are expressed as mean ± SE, n = 8
  2. LCl-carnitine, ASP-LD a low dose of aspartame, ASP-HD a high dose of aspartame, BDNF brain-derived neuroatrophic factor, COX-2 cyclooxygenase-2, PGE2 prostaglandin E2
  3. aSignificant difference as compared to control
  4. bSignificant difference as compared to ASP-LD
  5. cSignificant difference as compared to its relative group of ASP (P ≤ 0.05).
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