Table 2 Disorders and its behavioural effect modelled in zebrafish
From: Zebrafish as a prodigious tool in neuropsychiatric research
Disorder | Inducing agent | Mode of action | Outcome |
|---|---|---|---|
Autism | MK-801 L-NAME | NMDA antagonist | ➢ Impaired memory ➢ Decreased shoal cohesion ➢ Decreased social preference |
Schizophrenia | NO synthase inhibitor | ||
Anxiety | Ethanol | GABA-A receptor modulator | Anti-predation impaired by high doses |
Stress | |||
Alarm substance | Hypoxanthine-3N-oxide | Increases anxiety | |
Pentylene-tetrazole | GABA antagonist | ||
Caffeine | Xanthine alkaloid | ||
Sleep disorders | Pentobarbital | Barbiturate | Hypnotic |
Diazepam | Benzodiapine | ||
Reward-related behaviour | Ethanol | GABA-A receptor modulator | Rewarding |
Morphine | Opiate | ||
Cocaine | Psychostimulant | ||
Amphetamine |