Antinociceptive, antiinflammatory, and antipyretic effects induced by the venom of Egyptian scorpion Androctonus amoreuxi

The Journal of Basic and Applied Zoology

Table 2 Antiinflammatory effect of A. amoreuxi venom using Brewer’s yeast-induced paw oedema in rats

Paw thickness (cm)
Treatment	Initial	After 3 h	After 6 h
Yeast control	0.869 ± 0.029	0.825 ± 0.02	0.8 ± 0.031
Yeast + 1/10 LD₅₀ (0.385 mg/kg) A. amoreuxi venom	0.894 ± 0.023	0.894 ± 0.023 (6.788)	0.693 ± 0.020* (13.375)
Yeast + 1/5 LD₅₀ (0.77 mg/kg) A. amoreuxi venom	0.888 ± 0.026	0.756 ± 0.017* (8.364)	0.669 ± 0.019* (16.375)
Yeast + diclofenac sodium (20 mg/kg)	0.825 ± 0.015	0.719 ± 0.024*^# (12.848)	0.638 ± 0.018*^# (20.25)

Data are presented as mean ± SEM (6 animals/group)
*A significant difference between yeast control and treated groups using Student’s unpaired t test (p < 0.05)
#A significant difference between all groups at time intervals (3 and 6 h) using one-way ANOVA (p ≤ 0.05). Values between brackets represent percentage of inflammation inhibition