The Journal of Basic and Applied Zoology

Table 3 Effect of OL administration on severity of histopathologic lesions in DOX-treated rats

From: Polyphenolic-enriched olive leaf extract attenuated doxorubicin-induced cardiotoxicity in rats via suppression of oxidative stress and inflammation

Groups	Disorganization	Focal necrosis	Degeneration	Inflammation
Control	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00
DOX 10 mg/kg	3.00 ± 0.00^a	1.83 ± 0.17^a	2.17 ± 0.31^a	2.00 ± 0.26^a
DOX + OL LD	1.33 ± 0.21^a	0.67 ± 0.21^a	0.67 ± 0.21^a	1.00 ± 0.36^a
DOX + OL MD	1.00 ± 0.00^a	0.33 ± 0.21^a	0.33 ± 0.21^a	0.67 ± 0.21^a
DOX + OL HD	0.50 ± 0.22^a	0.17 ± 0.17^a	0.10 ± 0.00^a	0.50 ± 0.22^a

Effect of DOX and OL on histopathological changes in cardiac tissues. Severity of injury is depicted as mean ± SEM of three scores for six animals in each group. a P < 0.05 versus DOX group. Grade 1 < 5% mild. Grade 2 = 16–25% moderate. Grade 3 > 35% severe

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