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Table 1 The action of MECA on hot plate test

From: Potential pharmacological properties of methanol leaves extract of Culcasia Angolensis (Araceae): antinociceptive, antiinflammatory and antipyretic activities in laboratory animals

Treatments (mg/kg)

Mean reaction time

0 min

60 min

90 min

120 min

150 min

N/S (10 ml/kg)

1.63 ± 0.10

1.44 ± 0.22

1.34 ± 0.23

1.36 ± 0.28

1.49 ± 0.19

MECA 125

1.67 ± 0.14

3.25 ± 0.39

3.32 ± 0.14**

3.01 ± 0.24*

3.02 ± 0.29*

MECA 250

1.81 ± 0.25

2.82 ± 0.14

3.02 ± 0.16*

3.28 ± 0.31**

3.29 ± 0.18**

MECA 500

2.08 ± 0.20

2.99 ± 0.19

2.69 ± 0.19

3.87 ± 0.27**

3.81 ± 0.24**

MOR (10)

1.73 ± 0.19

3.37 ± 0.20**

3.07 ± 0.41**

3.73 ± 0.16**

3.72 ± 0.27**

  1. The values were analysed by repeated-measures ANOVA followed by Bonferroni post hoc test and presented as mean ± SEM
  2. N/S, normal saline; MECA, methanol leaf extract of Culcasia angolensis; MOR, morphine
  3. *p ≤ 0.05, **p ≤ 0.01 significant statistical increase in mean reaction time compared with time zero; n = 6