Table 2 The levels of total cholesterol (TC), low- and high-density lipoprotein cholesterols (LDL-C & HDL-C), and triglycerides in serum of the control rats and those orally administrated PZA alone, NGN 1 h prior to PZA, and NGN alone, every day for 7, 14, 21 & 28 days. Data are displayed as mean (of 5 rats) ± standard error of mean

TC

(mg dL⁻¹)

7

120.60 ± 0.76^a

120.68 ± 0.43^a

120.51 ± 1.13^a

120.61 ± 0.78^a

F_{3, 16} = 0.008, P = 0.999

14

120.55 ± 0.42^a

122.68 ± 0.81^a

120.72 ± 0.94^a

120.69 ± 0.97^a

F_{3, 16} = 1.554, P = 0.239

21

120.71 ± 0.78^a

135.81 ± 1.78^b*

120.60 ± 0.62^a

120.79 ± 0.68^a

F_{3, 16} = 49.12, P = 0.000

28

120.70 ± 1.01^a

149.03 ± 1.56^b*

120.79 ± 0.35^a

120.66 ± 0.83^a

F_{3, 16} = 187.9, P = 0.000

r

–

 + 0.94

 + 0.05

 + 0.02

Time effect

F_{3, 16} = 0.011, P = 0.998

F_{3, 16} = 107.08, P = 0.000

F_{3, 16} = 0.023, P = 0.995

F_{3, 16} = 0.008, P = 0.999

LDL-C

(mg dL⁻¹)

7

60.66 ± 0.52^a

62.30 ± 2.29^a

60.83 ± 2.57^a

60.90 ± 1.06^a

F_{3, 16} = 0.175, P = 0.912

14

60.84 ± 0.66^a

64.89 ± 1.95^b

60.54 ± 0.75^a

60.80 ± 0.81^a

F_{3, 16} = 3.206, P = 0.051

21

60.72 ± 0.97^a

79.03 ± 3.26^b*

60.79 ± 0.86^a

60.57 ± 1.10^a

F_{3, 16} = 24.93, P = 0.000

28

60.70 ± 0.80^a

98.11 ± 2.61^b*

60.91 ± 0.56^a

60.97 ± 0.33^a

F_{3, 16} = 175.9, P = 0.000

r

–

 + 0.90

 + 0.02

 − 0.001

Time effect

F_{3, 16} = 0.011, P = 0.998

F_{3, 16} = 40.81, P = 0.000

F_{3, 16} = 0.012, P = 0.998

F_{3, 16} = 0.039, P = 0.989

HDL-C

(mg dL⁻¹)

7

39.04 ± 0.35^a

37.41 ± 2.17^a

38.98 ± 1.61^a

38.73 ± 0.53^a

F_{3, 16} = 0.305, P = 0.821

14

38.82 ± 0.22^b

36.34 ± 1.62^a

39.32 ± 0.29^b

38.85 ± 0.17^b

F_{3, 16} = 2.609, P = 0.087

21

39.08 ± 0.65^b

33.99 ± 1.85^a

38.74 ± 0.59^b

39.45 ± 0.76^b

F_{3, 16} = 5.509, P = 0.009

28

39.04 ± 1.66^b

22.29 ± 1.92^a*

38.91 ± 0.59^b

38.72 ± 0.46^b

F_{3, 16} = 39.36, P = 0.000

r

–

 − 0.75

 − 0.05

 + 0.06

Time effect

F_{3, 16} = 0.016, P = 0.997

F_{3, 16} = 13.45, P = 0.000

F_{3, 16} = 0.071, P = 0.975

F_{3, 16} = 0.432, P = 0.733

TG

(mg dL⁻¹)

7

104.55 ± 0.98^a

104.89 ± 1.48^a

103.48 ± 0.64^a

104.91 ± 1.09^a

F_{3, 16} = 0.379, P = 0.77

14

104.44 ± 0.80^a

107.21 ± 2.10^a

104.29 ± 1.43^a

105.20 ± 1.50^a

F_{3, 16} = 0.772, P = 0.527

21

104.57 ± 1.02^a

113.93 ± 1.63^b*

105.38 ± 1.39^a

103.85 ± 1.27^a

F_{3, 16} = 12.25, P = 0.000

28

104.86 ± 1.07^a

143.15 ± 2.45^b*

104.87 ± 1.68^a

104.87 ± 1.00^a

F_{3, 16} = 133.24, P = 0.000

r

–

 + 0.86

 + 0.21

 − 0.07

Time effect

F_{3, 16} = 0.034, P = 0.991

F_{3, 16} = 81.71, P = 0.000

F_{3, 16} = 0.365, P = 0.779

F_{3, 16} = 0.231, P = 0.874