Table 4 The levels of glucose, total and indirect bilirubin (TBIL & IBIL) as well as the activities of aspartate and alanine aminotransferases (ASAT & ALAT) in serum of the control rats and those orally administrated PZA alone, NGN 1 h prior to PZA, and NGN alone, every day for 7, 14, 21 & 28 days. Data are displayed as mean (of 5 rats) ± standard error of mean

Glucose

(mg dL⁻¹)

7

120.20 ± 1.54^a

118.70 ± 2.64^a

119.54 ± 0.42^a

118.40 ± 2.67^a

F_{3, 16} = 0.161, P = 0.921

14

120.24 ± 1.13^a

120.70 ± 1.44^a

120.28 ± 1.00^a

120.02 ± 0.92^a

F_{3, 16} = 0.062, P = 0.979

21

121.58 ± 0.91^a

127.30 ± 1.62^b*

121.98 ± 0.91^a

121.42 ± 1.02^a

F_{3, 16} = 6.021, P = 0.006

28

123.04 ± 1.21^a

132.26 ± 2.45^b*

121.60 ± 1.01^a

122.18 ± 1.02^a

F_{3, 16} = 10.59, P = 0.000

r

–

 + 0.77

 + 0.44

 + 0.41

Time effect

F_{3, 16} = 1.217, P = 0.336

F_{3, 16} = 8.756, P = 0.001

F_{3, 16} = 1.714, P = 0.204

F_{3, 16} = 1.099, P = 0.378

TBIL

(mg dL⁻¹)

7

0.67 ± 0.01^a

0.68 ± 0.02^a

0.66 ± 0.01^a

0.69 ± 0.03^a

F_{3, 16} = 0.554, P = 0.653

14

0.68 ± 0.01^a

0.74 ± 0.04^a

0.69 ± 0.04^a

0.67 ± 0.03^a

F_{3, 16} = 0.787, P = 0.519

21

0.68 ± 0.01^a

0.80 ± 0.02^b*

0.70 ± 0.02^a

0.68 ± 0.02^a

F_{3, 16} = 13.14, P = 0.000

28

0.69 ± 0.01^a

0.83 ± 0.01^b*

0.69 ± 0.02^a

0.68 ± 0.03^a

F_{3, 16} = 16.32, P = 0.000

r

–

 + 0.75

 + 0.27

 − 0.06

Time effect

F_{3, 16} = 0.764, P = 0.531

F_{3, 16} = 7.267, P = 0.003

F_{3, 16} = 0.681, P = 0.577

F_{3, 16} = 0.061, P = 0.98

IBIL

(mg dL⁻¹)

7

0.57 ± 0.01^a

0.58 ± 0.01^a

0.55 ± 0.01^a

0.58 ± 0.03^a

F_{3, 16} = 0.397, P = 0.757

14

0.58 ± 0.01^a

0.63 ± 0.04^a

0.59 ± 0.03^a

0.57 ± 0.04^a

F_{3, 16} = 0.598, P = 0.626

21

0.58 ± 0.02^a

0.69 ± 0.01^b*

0.59 ± 0.01^a

0.58 ± 0.01^a

F_{3, 16} = 12.37, P = 0.000

28

0.59 ± 0.01^a

0.71 ± 0.02^b*

0.59 ± 0.02^a

0.58 ± 0.02^a

F_{3, 16} = 12.98, P = 0.000

r

–

 + 0.70

 + 0.25

 − 0.02

Time effect

F_{3, 16} = 0.518, P = 0.676

F_{3, 16} = 5.381, P = 0.009

F_{3, 16} = 0.694, P = 0.569

F_{3, 16} = 0.023, P = 0.995

ASAT

(U/mL)

7

34.50 ± 1.15^a

35.60 ± 1.23^a

34.10 ± 0.79^a

33.68 ± 0.82^a

F_{3, 16} = 0.657, P = 0.59

14

36.10 ± 0.94^a

37.72 ± 1.37^a

36.58 ± 1.01^a

35.30 ± 1.28^a

F_{3, 16} = 0.76, P = 0.533

21

32.60 ± 1.08^a

46.32 ± 1.52^b*

35.60 ± 1.30^a

33.10 ± 1.12^a

F_{3, 16} = 25.55, P = 0.000

28

34.92 ± 1.17^a

55.26 ± 1.29^b*

33.52 ± 1.29^a

34.00 ± 1.76^a

F_{3, 16} = 57.56, P = 0.000

r

–

 + 0.92

 − 0.12

 − 0.05

Time effect

F_{3, 16} = 1.797, P = 0.188

F_{3, 16} = 43.78, P = 0.000

F_{3, 16} = 1.558, P = 0.238

F_{3, 16} = 0.521, P = 0.674

ALAT

(U/mL)

7

25.80 ± 0.39^a

25.38 ± 1.18^a

25.16 ± 1.09^a

25.18 ± 1.41^a

F_{3, 16} = 0.075, P = 0.973

14

24.16 ± 0.69^a

29.00 ± 2.12^a

25.42 ± 1.38^a

22.68 ± 1.16^a

F_{3, 16} = 1.768, P = 0.194

21

24.76 ± 0.65^a

38.28 ± 1.28^b*

24.64 ± 1.42^a

23.80 ± 1.37^a

F_{3, 16} = 32.49, P = 0.000

28

25.86 ± 1.32^a

41.22 ± 0.72^b*

26.82 ± 1.29^a

23.94 ± 1.15^a

F_{3, 16} = 47.89, P = 0.000

r

–

 + 0.90

 + 0.17

 − 0.11

Time effect

F_{3, 16} = 0.984, P = 0.425

F_{3, 16} = 46.03, P = 0.000

F_{3, 16} = 0.512, P = 0.68

F_{3, 16} = 0.643, P = 0.598