Fig. 1

A photomicrograph of pancreatic tissues staining H &E: a From control mouse showing normal appearance of inlet Langerhans (Lg), acini cells (double head arrow) and pancreatic duct (d). b1 From gentamicin treated mice showing severe atrophied islets Langerhans with pyknosis of remaining cell’s nucleus (Lg) as well as widening space between lobules (w). Shrinkage and degenerated acini cells (double head arrow) and distracted pancreatic duct (d) were also seen. b2 From gentamicin treated mice showing moderate reduced Langerhans (Lg) with pyknotic nucleus of its cells and diffused empty space of degenerative cells (arrow) as well as degenerative acinar cells (double head arrow). mild perivascular inflammatory cells (arrow head), marked dilated pancreatic duct filled with eosinophilia materials (d),thickened haylinized wall of dilated artery (a), dilated congested vein (V) and edema with inflammatory cells infiltrations (o) were seen. b3 From gentamicin treated mice showing widening space (w) between small lobules (L). c From gentamicin–Trigon treated group revealing normal appearance of acini (double head arrow) and well developed islets of Langerhans (Lg) with focally empty space of degenerative cells (arrow). Moderate dilated pancreatic duct (d) and mild hylinized artery (a) were seen. d From gentamicin-G.Trigon treated group showing no structural abnormalities in islets of Langerhans (Lg), pancreatic acini (double head arrow) and pancreatic duct (d)