- Open Access
The role of probiotics on animal health and nutrition
The Journal of Basic and Applied Zoology volume 82, Article number: 52 (2021)
The constant global need for food has created a demand for colossal food production. Every day the world requires more food than it is capable of growing and harvesting. Antibiotics have been used in healthy food products to promote growth and prevent disease in food-producing animals for a long time. This prolonged use of antibiotics leads to the development of resistant bacteria and the accumulation of antibiotic residue in livestock and fish. To avoid further causalities finding an effective alternative became a dire need. At present, the most suitable alternative for antibiotics is probiotics.
Probiotics are live microorganisms that provide health benefits when consumed or applied to the body with the optimum amount. Probiotics are mainly good bacteria and yeast which fight off the pathogenic bacteria, improve the immune system, and restore the gut microbial balance. Probiotics can eliminate the harmful pathogens following several molecular mechanisms and modulate the immune response of the host animal for the well-being of the animals. This review article aims to describe probiotics as a potential growth promoter in major food sectors (poultry, ruminant, and aquaculture), how probiotics can ensure food safety without harmful effects on animals, and find out some points where more research is required to ensure a positive outcome.
The conclusion of this review article highlights the knowledge gaps and how they can be minimized using modern molecular technologies to establish probiotic supplements as an effective alternative to antibiotics.
The world population is increasing rapidly. It is assumed to extend to over 9.8 billion people by 2050, United Nations Department of Economic and Social Affairs Population Division (2017). This growing population is imposing food security challenges worldwide. Livestock farming is one of the rapidly expanding agricultural sectors. Generally, 75% of rural people and 25% of urban people rely on livestock for their sustenance, Grace (2012). Aquaculture is also developing as a primary agribusiness sector for the ever-increasing global human population. This sector has been advancing swiftly due to the enhanced cultivation methods in inland water bodies Hai (2015).
To maintain the enormous need for meat and fish production, veterans and farmers use antibiotics in the veterinary sector as antimicrobial growth promoters (AGPs) (Li et al., 2020; Marshall & Levy, 2011). The setback here is that it comes with harmful consequences. People use feed antibiotics as sub-therapeutic drugs for animal growth, but excessive and improper antibiotic use can develop antibiotic resistance in microbial populations (Deng et al., 2020a, 2020b; Han et al., 2020). This unnatural use of antibiotics has turned out into a public concern because of its affiliation with human and animal disorders. Later, the EU Regulation (EC) No 1831/2003 prohibited the unauthorized sale of dietary additives, including probiotics, without precisely labeling the product with an exact name and well-functioning group additives. The regulation also stated that the manufacturing company responsible for producing the supplements should mention the name, net weight, and net volume of the specific product appropriately. The product must also have the manufacturing date, including batch number and related information for product usage. The EU regulation also affirmed that companies could only authorize coccidiostats or histomonostats type antibiotics that might serve as dietary supplements, European Parliament and the Council of the European Union (2003).
Apart from antibiotic-caused illness, various foodborne pathogenic bacteria can cause major zoonotic diseases such as salmonellosis, campylobacteriosis, and pathogenic Escherichia coli infection in humans. These outbreaks create public health concerns and economic loss around the world. To face the current challenge of producing vast amounts of livestock and fish, probiotics have been found to improve animals' quality and growth without causing adverse effects.
Lilly and Stillwell (1965) first used the word probiotic as the opposite of the word antibiotic. By definition, probiotics are microbial substances capable of stimulating the expansion of another microorganism. Afterward, Fuller AFRC (1989) improved the description significantly, which was pretty near the definition used today. Fuller AFRC (1989) addressed probiotics as alive microbial feed additives that promisingly improve the host animals' intestinal microbial balance. FAO/WHO (2002) provided the current definition of probiotics which affirms that probiotics are active microbes that offer health values for the host animal when appropriately supplemented.
Probiotics can eliminate the pathogenic microorganisms from the GIT and change the host's microbial population density in the intestinal tract. Probiotics subsequently establish a better suited microbial population through a transformation in the equilibrium of beneficial and noxious microorganisms (Mountzouris et al., 2009). After probiotics settle in the gut, it prompts an immunologic response. The intestinal cells can assemble a series of immunoregulatory molecules exhilarated by bacteria (Corcionivoschi et al., 2010). Some probiotic metabolites can modulate various metabolic pathways in cells. Probiotic metabolic components such as bacteriocins, amines, and hydrogen peroxide interact with specific targets of multiple metabolic pathways to regulate apoptosis, cell proliferation, inflammation, and differentiation (Plaza-Diaz et al., 2019).
Nowadays, farmers provide probiotic feed supplements to poultry, ruminants, and fishes. Probiotics are mostly gram-positive bacteria but there are also gram-negative bacteria, yeast, and fungi. The most common probiotics used for animals (Table 1) incorporate Lactobacillus, Bifidobacterium, Lactococcus, Bacillus, Streptococcus, and yeast, such as Candida and saccharomyces (Arora, 2020; Park et al., 2016).
Probiotics have inaugurated a new era in health administration for animals. This study aims to analyze the role of probiotics on animal health and determine the prospects of sustainable probiotics utilization in this sector.
Mode of action of probiotics
Probiotics exert their effectiveness through diverse mechanisms. Probiotics inhibit and control enteric pathogens along with improving the functioning and production capacity of animals. Basic probiotic mode of action includes (a) inhibition of pathogen adhesion; (b) production of antimicrobial components, i.e., bacteriocins and defensins; (c) competitive exclusion of pathogenic microorganisms; (d) enhancement of barrier function; (e) reduction of luminal pH; and (f) modulation of the immune system (Fig. 1). Probiotics promote health conditions by inhibiting harmful bacteria. For instance, Lactobacillus rhamnosus and Lactobacillus plantarum can avert Escherichia coli adhesion in the intestinal tract (Maldonado Galdeano et al., 2019). Bacteria commonly interact with host cells following the secretion of chemical signals that influence bacterial organisms' approach (Miller & Bassler, 2001; Waters & Bassler, 2005). This communicating technique of bacteria with its host is called quorum sensing (Chen et al., 2020a, 2020b; Deng et al., 2020a, 2020b; Hughes & Sperandio, 2008). Probiotics can influence pathogenicity by modifying the communication process in pathogenic bacteria. Probiotics produce antibacterial substances and impede bacterial adherence and translocation. Lactobacillus, Leuconostoc, Pediococcus, Lactococcus, Enterococcus, Streptococcus, and Bifidobacteria can yield proteins or bacteriocins that minimize the development of closely linked bacterial organisms. These probiotics reduce the number of detrimental microorganisms from the gastrointestinal tract (Kawai et al., 2004; Yildirim & Johnson, 1998). Bacteriocins are bioactive antimicrobic peptides generated in the ribosome of many bacteria and stick to the pathogenic microorganism cells penetrating through the phospholipid membranes. The basic pattern of bacteriocin-mediated pathogen reaction encloses the cytoplasmic membrane penetration of pathogenic bacteria that confers in DNA and RNA synthesis inhibition and cell leakages (van Zyl et al., 2020). Bacteriocins can restrict pathogen cells' capability of GIT colonization and combat antibiotic-resistant strains of bacteria (Kuebutornye et al., 2020; Lajis, 2020). The following figure provides a streamlined illustration of the basic mechanisms of action of probiotics (Fig. 1).
Probiotic microbes can withstand pathogenic bacteria by lowering luminal pH. Probiotic Bifidobacterium breve can lower the luminal pH. Bifidobacterium breve can trigger acetic acid production in higher concentrations in a deadly Shiga toxin-yielding Escherichia coli O157:H7 mouse experimental model (Asahara et al., 2004). Probiotics can shape the cell–cell communication of bacteria and host and maintain cellular consistency by strengthening the intestinal barrier function. Such consistency is achieved through the modulation of cytoskeletal and tight junctional protein phosphorylation. Lactobacillus can abide by the epithelial cells of the ileum of chickens (Jin et al., 1996). Probiotics can competitively exclude pathogenic microorganisms from the host intestine by strengthening this intestinal communication system (Mookiah et al., 2014). This anti-pathogenic mechanism (competitive exclusion) demonstrates that bacterial species rigidly battle for attaching to receptors at particular binding sites in the GIT and might integrate antimicrobial substances secretion and competition for accessible nutrients (van Zyl et al., 2020).
Probiotics can improve the immunity of the host by modulating the immune system. The consumed probiotics play a crucial role in stimulating the mucosal immune system (MIS) and induce a network of signals. The reaction of diverse probiotic microbes on dendritic cells (DC) has been investigated in different experimental approaches. Dendritic cells are antigen-displaying cells that have crucial roles in innate and adaptive immunity. Dendritic cells can identify and react to bacterial components besides launching primary immune responses, which lead to the straight development of T- and B-cell responses. Probiotics can directly govern intestinal dendritic cells with pathogen recognition patterns (PRPs) displayed on the surface, which can precisely recognize the pathogen-associated molecular patterns (PAMPs) on the bacterial organism. This acknowledging method stimulates DC maturation regarding up-regulation of co-stimulatory molecular expression. As the immune system becomes active, cytokine secretion incites T-cell activation (Langenkamp et al., 2000; Mellman & Steinman, 2001). DC-originated signals ascertain the type of T-cells responses such as T helper cells polarization or T regulatory response, which determines the B-cell responses against pathogenicity, Kapsenberg (2003).
Probiotics increase digestibility
Probiotics increase the rate of digestion in animals. Probiotics can ameliorate cecal microorganism constitution and nutrient digestion in broilers (Khalid et al., 2021). Probiotics boost the ileal digestibility of essential amino acids, with a 5 percent enhancement in chicken body weight, Zhang and Kim (2014) and can ameliorate the bioaccumulation of calcium in poultry (Chawla et al., 2013). (Maas et al., 2021) experimented with enzymes xylanase, phytase together with probiotics. They reported the impact of Bacillus amyloliquefaciens on digestion or metabolism and found better calcium absorption and improved microorganisms’ interactions in the gut.
Probiotics increase enzyme activity in the GIT and improve the digestibility of the food eaten by the host. For example, a study in buffalo calves showed that probiotic feed containing Lactobacillus acidophilus could ensure more dry matter intake, daily feed conversion efficiency, and apparent digestibility of nutrients compared to the control group (Sharma et al., 2018).
Probiotics improve the immune system
Probiotics can enhance immunity in the host in many ways. Multiple studies have proven the immunostimulatory properties of probiotics (Bilal et al., 2021; Kong et al., 2020; Punetha et al., 2018; Terada et al., 2020). Probiotics comprising Lactobacillus fermentum and Saccharomyces cerevisiae excited the gut T-cell immunity, highlighted by the enhanced yield of CD3+, CD4+, and CD8+ T-lymphocytes in the gastrointestinal tract of chickens (Bai et al., 2013). In neonatal chicks of three-day- and seven-day-old expression of CD3+, IL-2, and IFN-γ-genes were higher in the small intestine when provided food with probiotics Lactobacillus jensenii TL2937 and Lactobacillus gasseri TL2919 than without probiotics (Sato et al., 2009).
Probiotics can also boost serum immunoglobulin levels in chickens. A probiotic feed supplement containing Lactobacillus acidophilus, Bacillus subtilis, and Clostridium butyricum enhanced IgA and IgM serum levels in chickens, Zhang and Kim (2014).
The LAB (Lactic Acid Bacteria) can generate a broad range of antimicrobial compounds to reduce pathogenic attacks. These include antimicrobial peptides (AMPs), such as defensins, organic acids, bacteriocins, ethanol, carbon dioxide, and diacetyl, Liao and Nyachoti (2017). Organic acids like short-chain fatty acids, formic acids, and lactic acid have been proved to suppress potential harmful microbes of importance in farm animals. Lactobacillus bacteria can generate lactic acid as the main glucose metabolism product (Russo et al., 2017). Organic acids work on the bacterial cell wall, cytoplasmic membrane, and precise metabolic functions such as replication and protein synthesis, which lead to the destruction and death of pathogenic microorganisms (Surendran Nair et al., 2017; Zhitnitsky et al., 2017). Salmonella Enteritidis, Lactobacillus monocytogenes, and Escherichia coli could be effectively inactivated after exposure to 0.5% lactic acid for two hours (Wang et al., 2015).
Probiotics can influence both the innate and adaptive immunity of the host. Several immune cell types, comprising granulocytes, dendritic cells, macrophages, T lymphocytes, and B lymphocytes, are engaged with inflammatory responses, which are regulated by cytokines like TNFα, IL-8, IL-1β, IL-15, and IL-6 interleukins. The anti-inflammatory reactions are mediated by TGFβ, IL-10, IL-12 (Hardy et al., 2013). Innate immunity provides physical and chemical barriers against pathogens for the host organism. For example, intestinal epithelial cells (IECs) prevent the spread of harmful microbes so that infections don not occur. It has been reported that Lactobacillus bacteria such as Lactobacillus gasseri, Lactobacillus salivarius, Lactobacillus fermentum, and Lactobacillus crispatus can regulate favorably the secretion level of the pro- and anti-inflammatory interleukins IL-6, IL-8, and IL-10 to manage the inflammation and rebuild the physiological balance in animals (Luongo et al., 2013; Pérez-Cano et al., 2010; Rizzo et al., 2015; Sun et al., 2013). Lactobacillus delbrueckii strain can stimulate anti-inflammatory properties and capable of downregulating the pro-inflammatory cytokines IL-8 levels. These inflammatory responses were seen in Aeromonas hydrophila contaminated carp (Cyprinus carpio Huanghe var.) when supplemented with 1 × 107 CFU g/L Lactobacillus delbrueckii probiotics (Zhang et al., 2017). The adaptive immune response is dependent on B-lymphocytes and T-lymphocytes, which stimulate an antigen-specific response. In poultry, feed supplementation with 1 × 109 CFU/kg of Lactobacillus acidophilus LA5 elevated the amount of CD8+, CD4+, TCR1+ T-cell in the gastrointestinal tract as well as in the peripheral blood system (Asgari et al., 2016).
Role of probiotics in poultry
The world's poultry production now is five times higher than the poultry production of 50 years ago, FAOSTAT (2016). Evaluation from the 2016 "Global Livestock Environmental Assessment Model" FAO (2018) discloses that around 73 million tons of eggs and approximately 100 million tons of poultry meat have been required worldwide. Probiotics can help to meet this massive need without exerting harmful effects (Fig. 2).
Probiotics can improve the growth rates of broiler chicken (Abd El-Hack et al., 2020; Afsharmanesh & Sadaghi, 2014; Lei et al., 2015; Mookiah et al., 2014; Zhang & Kim, 2014). Probiotics can prevent gastrointestinal diseases like salmonellosis (Biloni et al., 2013; El-Sharkawy et al., 2020; Fazelnia et al., 2021; Tellez et al., 2012); necrotic enteritis (Jayaraman et al., 2013; Rajput et al., 2020; Xu et al., 2020); as well as coccidiosis (El-Sawah et al., 2020). Broiler chickens fed with Lactobacillus acidophilus, Lactobacillus casei, and Bifidobacterium at about 1 percent of the food amount comprising over 5 × 109 CFU/g can improve the chickens' growth rate, immune system, and antioxidant quantity (Zhang et al., 2021).
Probiotics can modify the histology of the intestinal mucosa of poultry. The intestinal mucosa framework is a crucial factor for both digestive and absorptive intestinal function and affects the poultry's growth. The villus height and the villus-to-crypt ratio of intestinal mucus layer were enhanced by Bacillus subtilis (Afsharmanesh & Sadaghi, 2014; Jayaraman et al., 2013); Bacillus coagulans (Hung et al., 2012), Lactobacillus salivarius, Pediococcus parvulus (Biloni et al., 2013), and Enterococcus faecium (Abdel-Rahman et al., 2013; Cao et al., 2013). Along with the improvement in villus height and villus height-to-crypt ratio, the assimilation of nutrients also increases owing to a greater surface area, Afsharmanesh and Sadaghi (2014). The use of Lactobacillus sakei Probio-65 ameliorated villi height likewise crypt depth in the jejunum of broiler chicken compared with chickens supplemented with or without antibiotics (Wlodarska et al., 2011).
Probiotics can prevent salmonellosis in chickens. Hatched chicks that were vaccinated with 1 × 109 CFU Lactobacillus plantarum LTC-113 strain can prevent salmonellosis. Lactobacillus plantarum can limit the gut colonization of harmful bacteria and stabilize the expression of tight junction genes in gut epithelial cells, thus make the chickens better tolerant of the infection (Wang et al., 2018). As broiler chickens get affected by APEC and Salmonella, the latest research indicated that when probiotics and RASV are provided in a combination for the White leghorn chickens that can decrease the rate of infection in leghorn chickens (Redweik et al., 2020). Bacillus licheniformis and Bacillus subtilis containing feed supplement can reduce the shedding of Escherichia coli in laying hens (Upadhaya et al., 2019).
Campylobacteriosis is another major illness of poultry caused by Campylobacter jejuni. In chicken, in vitro experiments with probiotic bacterial strains such as Pediococcus acidilactici, Lactobacillus reuteri, Enterococcus faecium, and Lactobacillus salivarius showed that the probiotics could impede the growth of Campylobacter jejuni (Ghareeb et al., 2012). Feeding the artificially infected chicken a commercial mixture of probiotic Lactobacillus acidophilus and Enterococcus faecium decreased the shedding of Campylobacter by 70 percent and the gut colonization of Campylobacter by 27 percent (Morishita et al., 1997).
Coccidiosis is another crucial parasitic disease of poultry resulting from a protozoan, Eimeria. Eimeria colonizes the intestinal tract. When probiotics supplementation is provided including Bifidobacterium animalis, Enterococcus faecium, Bacillus subtilis, and Lactobacillus reuteri, either individually or in combination, it can lower down the infection rate (Giannenas et al., 2012).
Probiotics improve the laying performance of hens and egg quality. Lohmann pink laying hens which are nourished with Clostridium butyricum, Saccharomyces boulardii, and pediococcus acidilactici have improved the gastrointestinal state and egg quality (Xiang et al., 2019). When brown laying hens are given Bacillus subtilis ATCC PTA- 6737 at 1 × 108 CFU/kg feed, the laid eggs have better yolk color, albumen quality, shell thickness, and breaking strength than the eggs laid by control group hens, Sobczak and Kozłowski (2015). Probiotics can efficiently minimize the egg yolk cholesterol level. Bacillus spores, lactic acid bacteria, and yeast can minimize the cholesterol level of the egg yolk (Haddadin et al., 1996; Kurtoglu et al., 2004; Panda et al., 2003; Yousefi, & Karkoodi, 2007).
Probiotics improve the meat quality of the chicken. Bacillus subtilis can upgrade chicken meat quality (Mohammed et al., 2021). Bifidobacterium bifidum and Bacillus toyonensis can enhance the growth rate and meat quality in quails (Abou-Kassem et al., 2021). Lactobacillus casei can elevate the high-density lipoprotein (HDL) level and mitigate the low-density lipoprotein (LDL) level in broiler chicken (Yulianto et al., 2020). Lactobacillus acidophilus together with Streptococcus faecium enhances the protein amount in meat by lowering high-density lipoprotein cholesterol levels and plasma protein concentrations, Pietras (2001). Additional works based on Lactobacillus spp. supplementation offered similar results, with minimization in the whole cholesterol levels and low-density lipoprotein cholesterol levels (Kalavathy et al., 2003; Taherpour et al., 2009), as well as triglycerides level in blood serum of broilers (Kalavathy et al., 2003).
Probiotics provide immunomodulatory responses. Probiotics supplementation helps broiler chickens to cope up with stress conditions. Lactic acid bacteria (LAB) probiotics addition as a food supplement can rectify heat-stress-relevant diseases in chickens (Abd El-Hack et al., 2020). Lactic acid bacteria can improve antibody production (Zulkifli et al., 2000). Probiotics can enhance immunity by increasing the Toll-like receptor (TLR) signaling. Toll-like receptor (TLR) plays a crucial role in the activation of T-cells in the intestinal immune system (Asgari et al., 2018). Lactobacillus fermentum and Saccharomyces cerevisiae can strengthen the degree of mRNA expression of TLR-2 and TLR-4 in the foregut of the chickens in respect of those treated with or without an antibiotic (Bai et al., 2013).
Role of probiotics in ruminants
The rumen has an intricate microbial population. Host animals ingest carbohydrates and proteins, which are degraded by rumen microorganisms. The commonly used probiotics for ruminants are Saccharomyces cerevisiae (Chaucheyras-Durand et al., 2008; Elghandour et al., 2020), Lactic acid bacteria (LAB) (Chiquette et al., 2008; Weimer, 2015); Aspergillus oryzae (Jouany et al., 1998; Mathieu et al., 1996); Bacillus and Enterococcus (Uyeno et al., 2015) which confer significant well-being for the ruminant health (Fig. 2).
Probiotics can enhance milk production in dairy cattle. Probiotic microorganisms such as Bacillus sublitis, Saccharomyces cerevisiae, and Enterococcus faecalis can enrich milk secretion (Ma et al., 2020), and also Bifidobacterium bifidum can inhibit milk allergy reaction (Jing et al., 2020). Cows supplemented with 5 × 109 CFU of Enterococcus faecium and 2 × 109 CFU Saccharomyces cerevisiae cells enhanced milk production by 2.3 L per cow each day, Nocek and Kautz (2006). A rigorous quantitative study on yeast probiotics' implications in ruminants demonstrated that ruminants fed with active yeast probiotics increased milk production by nearly 1.2 g/kg of body weight. Dry matter intake (DMI) by the farm animals was elevated nearly 0.44 g/kg of bodyweight though there was no effect on milk protein amount (Desnoyers et al., 2009).
Probiotics can increase the ruminants' body weight. For instance, a probiotic combination of Lactobacillus reuteri DDL 19, Lactobacillus alimentarius DDL 48, Enterococcus faecium DDE 39, and Bifidobacterium bifidum DDBA collected from a fine goat and fed to other goats for about two months. This caused an improvement in the goat's standard bodyweight by nine percent (Apás et al., 2010). Bacillus subtilis and Bacillus amyloliquefaciens can upgrade intestinal maturation and growth competency by stimulating GH/IGF-1 hormone (Du et al., 2018).
Probiotics can increase food digestibility in ruminants. Using a mixture of Lactobacillus acidophilus NP51 and Propionibacterium freudenreichii NP24 as cow feed has improved the digestion of neutral detergent fiber, crude protein, and milk yield by nearly 7.6 percent (Boyd et al., 2011).
Probiotics can enhance the immune system in ruminants. The supplementation of Lactobacillus acidophilus, Lactobacillus salivarius, and Lactobacillus plantarum at a pace of 107–108 CFU/g bring down the occurrence of diarrhea in juvenile calves (Signorini et al., 2012). Nisin is an antimicrobial peptide generated from Lactococcus lactis. Nisin infusion in the intra-mammary gland can treat mastitis, which is caused by Staphylococcus aureus in dairy cows (Cao et al., 2007). Lactobacillus base teat spray can improve mammary gland condition and strengthen the functions of the teat sphincter (Alawneh et al., 2020). Probiotics supplementation can alleviate rumen acidosis in cows and improve immunity in young stressed calves (Krehbiel et al., 2003).
Probiotics can strengthen rumen fermentation. Multiple probiotic strains have been proved to yield antimicrobial components that can decrease zoonotic pathogens and control ammonia production. Rhodopseudomonas palustris, a photosynthetic bacteria, have been considered a feasible probiotic in the animal feed sector (Chen et al., 2020a, 2020b) reported that Rhodopseudomonas palustris containing feed supplements can promote the viability of rumen microorganisms. They also noticed that Rhodopseudomonas palustris addition rendered high growth performance of rumen microorganisms and increased microbial fermentation to keep up the microbial balance. Application of Megasphaera elsdenii can ameliorate butyrate production and improve dietary intake in newborn calves (Muya et al., 2015).
Role of probiotics in aquaculture
In 2018, universal fish production was around 179 million tons, coupled with a total sale value estimated at USD 401 billion, FAO (2020). Antibiotics are extensively used to meet the increasing demand in aquaculture. However, this extensive use of antibiotics gives rise to the drug-resistant bacteria that transmit through the food web to human (Cabello, 2006; Da Costa et al., 2013; Hassoun-Kheir et al., 2020; Kim et al., 2004; Tanwar et al., 2014; Wanja et al., 2020).
Probiotics confer several beneficial effects to aqua-animals (Fig. 2). Probiotics promote the growth and reproduction of water-dwelling animals, safeguard from pathogens, strengthen immunity, help in digestion, improve water quality, and work as an alternative to antibiotics, Banerjee and Ray (2017).
Farmers use a broad range of probiotics in fish farming. Bacillus subtilis from Bacillus genera is frequently used in aquaculture (Hong et al., 2005; Olmos et al., 2020). Bacillus probiotics alone can mitigate various harmful microorganisms in fish such as Vibrio, Pseudomonas, Aeromonas, Clostridium, Streptococcus, Flavobacterium, Acinetobacter, and white spot syndrome virus (Kuebutornye et al., 2020). Other bacterial strains commonly used as probiotics in aquaculture are the LAB bacteria such as Lactococcus lactis (Balcázar et al., 2007) and Lactobacillus plantarum VSG-3 (Giri et al., 2013). A broad range of Gram-negative bacteria performs a vital role in fish farming. Several microalgae such as Dunaliella tertiolecta, Dunaliella salina, Isochrysis galbana, Phaeodactylum tricornutum, and Tetraselmis suecica have enhanced the development and survival rate of aquatic animals (Cahu et al., 1998; Marques et al., 2006; Naas et al., 1992; Reitan et al., 1997; Supamattaya et al., 2005). Yeast (Saccharomyces cerevisiae) has been proven useful for aquatic animals (Mo et al., 2020; Wu et al., 2020).
Farmers supply the fishes with probiotic feed supplement either through water circulation or dietary supplements (Moriarty, 1998; Skjermo & Vadstein, 1999). A single bacterial strain or a combination of several bacterial strains can be used as probiotics along with other prebiotics or immunostimulants (Hai et al., 2009a, 2009b). Achieving expected outcomes in fish culture depends on the proper dosage and timing.
Probiotics improve the health conditions of fish and other water-dwelling creatures Bacillus pumilus (Aly et al., 2008) and Lactobacillus plantarum (Van Doan et al., 2020) can ameliorate the health conditions of Nile tilapia. To mitigate the adverse impact of the Tilapia Lake Virus, dietary supplements of 1 percent Bacillus spp were given orally for the red hybrid Tilapia fishes (Waiyamitra et al., 2020). This feed supplement can reduce the fatality rate by Lake Virus infection. Probiotic Pseudomonas I-2 can inhibit disease-causing vibrio microorganisms (Chythanya et al., 2002). Probiotic Pediococcus acidilactici can resist vibriosis in white leg shrimp (Castex et al., 2008). Feeding White leg shrimp larvae with a variety of probiotic feed supplements (Lactobacillus, Saccharomyces, Bacillus, effective microorganisms such as gram-positive cocci and Bifidobacterium, and Photosynthetic Bacteria) can accelerate the growth speed and larval metamorphosis. It also encumbers incomplete molting during the development and minimizes the number of vibrio pathogens (Wang et al., 2020). Pediococcus pentosaceus and Staphylococcus hemolyticus can decrease the frequency of white spot syndrome virus in white leg prawns (Leyva-Madrigal et al., 2011). Saccharomyces cerevisiae can be used as a substitute for live food in the cultivation of clownfish (Gunasundari et al., 2013); Catla (Mohanty S.K.; Tripathi, S.D., 1996); hybrid striped bass (Li & Gatlin, 2004, 2005); Japanese flounder (Taoka et al., 2006) and Nile tilapia (Lara-Flores et al., 2003). Bifidobacterium animalis and Lactobacillus acidophilus-rich feed additives can ennoble the growth and lifespan of Hypophthalmichthys molitrix fingerlings (Noor et al., 2020).
Probiotics can enhance immune responses in fish. Bacillus activates the humoral and cell-mediated immunologic response in fish (Kuebutornye et al., 2020). Bacillus pumilus and Bacillus licheniformis strengthen the immunity of Nile tilapia (Aly et al., 2008) and Bacillus pumilus improves the immunity of rohu fish (Ramesh et al., 2015). Bacillus licheniformis assists in performing the immunomodulatory activities and raises Oreochromis niloticus production by up-regulating the Toll-like receptors (TLR-2) and anti-inflammatory cytokines (Midhun et al., 2019).
Probiotics can improve growth performance, feed intake, and digestive enzyme processes in aquatic animals. Probiotics generate extracellular enzymes such as protease, carbohydrase, and lipase and efficiently engage in the nutrient digestion of aquatic animals (Arellano-Carbajal & Olmos-Soto, 2002; Leonel Ochoa-Solano & Olmos-Soto, 2006). Bacillus generates different hydrolytic enzymes such as β-1,3-glucanases, proteases, and cellulases to improve the digestion in fish (Kuebutornye et al., 2020). In a sea snail, Haliotis midae, the probiotic Vibrio midae SY9 can reinforce digestive protease activity, protein digestion, and growth rate activities, Huddy and Coyne (2015). Bacillus spp. and photosynthetic bacteria can improve white leg prawns' growth through an increase in lipase and cellulase activity, Wang (2007). Pseudomonas aeruginosa and Pseudomonas synxantha can enhance the growth rate of western king prawns (van Hai et al., 2010, van Hai et al., 2009a, 2009b).
Probiotics can improve water quality. Probiotics have shown their potency in nourishing water properties, controlling disease, and thus upgrading fish habitat (Chen et al., 2020a, 2020b; Kewcharoen & Srisapoome, 2019; Soltani et al., 2019). Probiotics enhance water quality by reducing the number of harmful microbes (Dalmin et al., 2001; Park et al., 2000), mitigate nitrogen (Wang et al., 2005) and reduce phosphate contamination in the sediments, Wang and He (2009). Probiotics can alleviate metabolic wastes at the time of the fish school's transportation, cardinal tetra (Paracheirodon axelrodi) (Gomes et al., 2009).
Use of probiotics on miscellaneous animals
Probiotic feed supplements confer health values in farm animals such as sheep, lamb, pigs, rabbits, ducks, and turkeys. Scientists worldwide proposed different probiotic feed additives for the safe production of meat, egg, and milk maintaining these animals well-being. Probiotics can improve the health condition of sheep and lambs. Bacillus licheniformis and Bacillus subtilis can improve body weight, upgrade the intestinal microbiome, boost immunity, and preserve regular metabolic actions in two-month-old sheep and lambs (Devyatkin et al., 2021).
Probiotics can improve milk quality in ewes. Feed supplements including Bacillus subtilits and Bacillus licheniformis can lower mortality, improve milk protein content, and increase the production of milk in ewes (Kritas et al., 2006).
Probiotics can ameliorate the health condition of birds. When white Pekin ducks were given a dietary feed supplement containing Lactobacillus acidophilus and Lactobacillus casei that increased total weight gain, protein content, intestinal enzyme activity, bactericidal activity, and decreased cholesterol, glucose, and cortisol level (Khattab et al., 2021). Lactobacillus can produce lactic acid and reduce pathogenic infection maintaining intestinal microorganism balance in geese (Dec et al., 2014). In Cherry Valley Pekin ducks, Bacillus subtilis and Bacillus licheniformis can enhance LXRα and CYP7α1 enzyme activities in the liver and reduce lipid concentrations and fat deposition (Huang et al., 2015).
In neonatal turkey birds, lactic acid bacteria can fight back against Salmonella enteritis and Clostridium jejuni and improve GIT condition (Yang et al., 2018). Modified probiotic bacteria, Escherichia coli Nissle 1917, can secrete the antimicrobial peptide, Microcin J25 which diminishes Salmonella enteritidis in GIT of turkey (Forkus et al., 2017).
Probiotics can improve the health condition of rabbits. Clostridium butyricum can improve growth rate, gut microbial condition, and intestinal immunity in Rex rabbits. When healthy female rabbits were fed with Clostridium butyricum, it considerably ameliorated body weight, the action of digestive enzyme, improved the immune system by enhancing the abundance of beneficial bacteria (Liu et al., 2019). Bacillus subtilis containing feed supplements can improve growth performance, meat quality, and immune response in rabbits brought up in a heated environment (Fathi et al., 2017). Growing rabbits fed with Aspergillus awamori demonstrated improved body weight, nutrient digestibility, and better antioxidative responses (El-Deep et al., 2021).
Probiotics can improve the health status of pigs. Bacillus amyloliquefaciens is considered a useful dietary supplement against antibiotics in pigs and piglets for fattening (Cao et al., 2020). Pigs face much trouble during weaning which leads to immune and intestinal system malfunctions, upsets the gut microbial environment, and hampers the growth rate of piglets. Duan-Nai-An, an engineered Saccharomyces cerevisiae strain, can significantly improve body weight, feed intake, and decrease the rate of diarrhea and death in early-weaned piglets (Xu et al., 2018).
The world is being densely populated day by day. To meet the need for meat and fish production of this ever-growing population, some effective yet harmless solutions became a crying need. Probiotics have a vital role to solve this food production problem and replace the harmful antibiotic use in farm industries. Nonetheless, every unique probiotic cannot be guaranteed to provide safety with conventional strains. Some probiotics might have undesirable properties such as transmittable antimicrobial resistance, virulence factors, hemolytic potential, and unwanted yield of toxic biochemical substances. To avoid any causalities, distinct probiotic strains must be determined for individual species in a particular environment. The efficiency and reactions for every probiotic are dissimilar. So, the optimum condition for a probiotic to survive, colonize, expand, and render its effects to the hosts in a particular environment needs to be identified.
Modern molecular methods such as quorum sensing, different staining methods, polymerase chain reaction (PCR), scanning electron microscope, fluorescent in situ hybridization (FISH), and genome-wide association study (GWAS) could be applied. Implementing these techniques will successively help to find out the detail about the adherence and colonization of probiotic and pathogenic bacteria, interaction with the host and breeding environment, the communication process between probiotics and host mucosa, gene exchange or transfer horizontally or vertically. Proper knowledge of the immune-modulatory effects of different probiotics and their viability before probiotics which are added in farm animals' dietary feed is essential. Moreover, dosage-dependent studies should be done in greater detail by confirming the organism's identity using molecular testing at a reference laboratory. Additional investigations are required before providing guidelines for probiotics with any degree of confidence.
Availability of data and materials
Gastric Intestinal Tract
Tumor necrosis factor alpha
Transforming growth factor beta
Intestinal epithelial cell
Insulin-like growth factor 1
Avian pathogenic Escherichia coli
Recombinant attenuated Salmonella vaccines
Cluster of differentiation
Abd El-Hack, M. E., El-Saadony, M. T., Shafi, M. E., Qattan, S. Y. A., Batiha, G. E., Khafaga, A. F., Abdel-Moneim, A. M. E., & Alagawany, M. (2020). Probiotics in poultry feed: A comprehensive review. Journal of Animal Physiology and Animal Nutrition (berlin), 104, 1835–1850. https://doi.org/10.1111/jpn.13454
Abdel-Rahman, H. A., Shawky, S. M., Ouda, H., Nafeaa, A. A., & Orabi, S. H. (2013). Effect of two probiotics and bioflavonoids supplementation to the broilers diet and drinking water on the growth performance and hepatic antioxidant parameters. Global Vet. https://doi.org/10.5829/idosi.gv.2013.10.6.7459
Abou-Kassem, D. E., Elsadek, M. F., Abdel-Moneim, A. E., Mahgoub, S. A., Elaraby, G. M., Taha, A. E., Elshafie, M. M., Alkhawtani, D. M., Abd El-Hack, M. E., & Ashour, E. A. (2021). Growth, carcass characteristics, meat quality, and microbial aspects of growing quail fed diets enriched with two different types of probiotics (Bacillus toyonensis and Bifidobacterium bifidum). Poultry Science. https://doi.org/10.1016/j.psj.2020.04.019
Adami, A., & Cavazzoni, V. (1999). Occurrence of selected bacterial groups in the faeces of piglets fed with Bacillus coagulans as probiotic. Journal of Basic Microbiology, 39, 3–9. https://doi.org/10.1002/(SICI)1521-4028(199903)39:1%3c3::AID-JOBM3%3e3.0.CO;2-O
AFRC, R.F.,. (1989). Probiotics in man and animals. Journal of Applied Bacteriology. https://doi.org/10.1111/j.1365-2672.1989.tb05105.x
Afsharmanesh, M., & Sadaghi, B. (2014). Effects of dietary alternatives (probiotic, green tea powder, and Kombucha tea) as antimicrobial growth promoters on growth, ileal nutrient digestibility, blood parameters, and immune response of broiler chickens. Computation Clinical Path. https://doi.org/10.1007/s00580-013-1676-x
Alawneh, J. I., James, A. S., Phillips, N., Fraser, B., Jury, K., Soust, M., & Olchowy, T. W. J. (2020). Efficacy of a Lactobacillus-based teat spray on udder health in lactating dairy cows. Frontiers Veterinary Science, 7, 1–9. https://doi.org/10.3389/fvets.2020.584436
Alexopoulos, C., Georgoulakis, I. E., Tzivara, A., Kritas, S. K., Siochu, A., & Kyriakis, S. C. (2004). Field evaluation of the efficacy of a probiotic containing Bacillus licheniformis and Bacillus subtilis spores, on the health status and performance of sows and their litters. Journal of Animal Physiology and Animal Nutrition (berlin). https://doi.org/10.1111/j.1439-0396.2004.00492.x
Aly, S. M., Mohamed, M. F., & John, G. (2008). Effect of probiotics on the survival, growth and challenge infection in Tilapia nilotica (Oreochromis niloticus). Aquaculture Research. https://doi.org/10.1111/j.1365-2109.2008.01932.x
Apás, A. L., Dupraz, J., Ross, R., González, S. N., & Arena, M. E. (2010). Probiotic administration effect on fecal mutagenicity and microflora in the goat’s gut. Journal of Bioscience and Bioengineering. https://doi.org/10.1016/j.jbiosc.2010.06.005
Arellano-Carbajal, F., & Olmos-Soto, J. (2002). Thermostable α-1,4- and α-1,6-glucosidase enzymes from Bacillus sp. isolated from a marine environment. World Journal of Microbiology and Biotechnology. https://doi.org/10.1023/A:1020433210432
Arora, N. K. (2020). Advances in probiotics for sustainable food and medicine.
Asahara, T., Shimizu, K., Nomoto, K., Hamabata, T., Ozawa, A., & Takeda, Y. (2004). Probiotic bifidobacteria protect mice from lethal infection with Shiga toxin-producing Escherichia coli O157:H7. Infection and Immunity. https://doi.org/10.1128/IAI.72.4.2240-2247.2004
Asgari, F., Falak, R., Teimourian, S., Pourakbari, B., Ebrahimnezhad, S., & Shekarabi, M. (2018). Effects of oral probiotic feeding on toll-like receptor gene expression of the chicken’s cecal tonsil. Reports Biochemistry and Molecular Biology.
Asgari, F., Madjd, Z., Falak, R., Bahar, M. A., Heydari Nasrabadi, M., Raiani, M., & Shekarabi, M. (2016). Probiotic feeding affects T cell populations in blood and lymphoid organs in chickens. Benef Microbes. https://doi.org/10.3920/BM2016.0014
Bai, S. P., Wu, A. M., Ding, X. M., Lei, Y., Bai, J., Zhang, K. Y., & Chio, J. S. (2013). Effects of probiotic-supplemented diets on growth performance and intestinal immune characteristics of broiler chickens. Poultry Science. https://doi.org/10.3382/ps.2012-02813
Balcázar, J. L., Rojas-Luna, T., & Cunningham, D. P. (2007). Effect of the addition of four potential probiotic strains on the survival of pacific white shrimp (Litopenaeus vannamei) following immersion challenge with Vibrio parahaemolyticus. Journal of Invertebrate Pathology. https://doi.org/10.1016/j.jip.2007.04.008
Banerjee, G., & Ray, A. K. (2017). The advancement of probiotics research and its application in fish farming industries. Research in Veterinary Science, 115, 66–77. https://doi.org/10.1016/j.rvsc.2017.01.016
Benmechernene, Z., Chentouf, H. F., Yahia, B., Fatima, G., Quintela-Baluja, M., Calo-Mata, P., & Barros-Velázquez, J. (2013). Technological aptitude and applications of leuconostoc mesenteroides bioactive strains isolated from algerian raw camel milk. Biomedical Research International. https://doi.org/10.1155/2013/418132
Bilal, M., Si, W., Barbe, F., Chevaux, E., Sienkiewicz, O., & Zhao, X. (2021). Effects of novel probiotic strains of Bacillus pumilus and Bacillus subtilis on production, gut health, and immunity of broiler chickens raised under suboptimal conditions. Poultry Science. https://doi.org/10.1016/j.psj.2020.11.048
Biloni, A., Quintana, C. F., Menconi, A., Kallapura, G., Latorre, J., Pixley, C., Layton, S., Dalmagro, M., Hernandez-Velasco, X., Wolfenden, A., Hargis, B. M., & Tellez, G. (2013). Evaluation of effects of EarlyBird associated with FloraMax-B11 on Salmonella enteritidis, intestinal morphology, and performance of broiler chickens. Poultry Science. https://doi.org/10.3382/ps.2013-03279
Boyd, J., West, J. W., & Bernard, J. K. (2011). Effects of the addition of direct-fed microbials and glycerol to the diet of lactating dairy cows on milk yield and apparent efficiency of yield. Journal of Dairy Science. https://doi.org/10.3168/jds.2010-3984
Cabello, F. C. (2006). Heavy use of prophylactic antibiotics in aquaculture: A growing problem for human and animal health and for the environment. Environmental Microbiology. https://doi.org/10.1111/j.1462-2920.2006.01054.x
Cahu, C. L., Zambonino Infante, J. L., Péres, A., Quazuguel, P., & Le Gall, M. M. (1998). Algal addition in sea bass (Dicentrarchus labrax) larvae rearing: Effect on digestive enzymes. Aquaculture. https://doi.org/10.1016/S0044-8486(97)00295-0
Cao, G. T., Zeng, X. F., Chen, A. G., Zhou, L., Zhang, L., Xiao, Y. P., & Yang, C. M. (2013). Effects of a probiotic, Enterococcus faecium, on growth performance, intestinal morphology, immune response, and cecal microflora in broiler chickens challenged with Escherichia coli K88. Poultry Science. https://doi.org/10.3382/ps.2013-03366
Cao, L. T., Wu, J. Q., Xie, F., Hu, S. H., & Mo, Y. (2007). Efficacy of nisin in treatment of clinical mastitis in lactating dairy cows. Journal of Dairy Science. https://doi.org/10.3168/jds.2007-0153
Cao, X., Tang, L., Zeng, Z., Wang, B., Zhou, Y., Wang, Q., Zou, P., & Li, W. (2020). Effects of probiotics BaSC06 on intestinal digestion and absorption, antioxidant capacity, microbiota composition, and macrophage polarization in pigs for fattening. Frontiers Vetnary Science. https://doi.org/10.3389/fvets.2020.570593
Castex, M., Chim, L., Pham, D., Lemaire, P., Wabete, N., Nicolas, J. L., Schmidely, P., & Mariojouls, C. (2008). Probiotic P. acidilactici application in shrimp Litopenaeus stylirostris culture subject to vibriosis in New Caledonia. Aquaculture. https://doi.org/10.1016/j.aquaculture.2008.01.011
Chaucheyras-Durand, F., Walker, N. D., & Bach, A. (2008). Effects of active dry yeasts on the rumen microbial ecosystem: Past, present and future. Animal Feed Science and Technology. https://doi.org/10.1016/j.anifeedsci.2007.04.019
Chawla, S., Katoch, S., Sharma, K. S., & Sharma, V. K. (2013). Biological response of broiler supplemented with varying dose of direct fed microbial. Vetanary World. https://doi.org/10.5455/vetworld.2013.521-524
Chen, B., Peng, M., Tong, W., Zhang, Q., & Song, Z. (2020a). The Quorum Quenching Bacterium Bacillus licheniformis T-1 protects Zebrafish against Aeromonas hydrophila infection. Probiotics Antimicrob Proteins. https://doi.org/10.1007/s12602-018-9495-7
Chen, Y. Y., Wang, Y. L., Wang, W. K., Zhang, Z. W., Si, X. M., Cao, Z. J., Li, S. L., & Yang, H. J. (2020b). Beneficial effect of Rhodopseudomonas palustris on in vitro rumen digestion and fermentation. Benef Microbes. https://doi.org/10.3920/BM2019.0044
Chiquette, J., Allison, M. J., & Rasmussen, M. A. (2008). Prevotella bryantii 25A used as a probiotic in early-lactation dairy cows: Effect on ruminal fermentation characteristics, milk production, and milk composition. Journal of Dairy Science. https://doi.org/10.3168/jds.2007-0849
Chythanya, R., Karunasagar, I., & Karunasagar, I. (2002). Inhibition of shrimp pathogenic vibrios by a marine Pseudomonas I-2 strain. Aquaculture. https://doi.org/10.1016/S0044-8486(01)00714-1
Corcionivoschi, N., Drinceanu, D., Pop, I. M., Stack, D., Ştef, L., Julean, C., & Bourke, B. (2010). The Effect of Probiotics on Animal Health REVIEW, Scientific Papers: Animal Science and Biotechnologies.
Da Costa, P. M., Loureiro, L., & Matos, A. J. F. (2013). Transfer of multidrug-resistant bacteria between intermingled ecological niches: The interface between humans, animals and the environment. International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph10010278
Dalmin, G., Kathiresan, K., Purushothaman, A., 2001. Effect of probiotics on bacterial population and health status of shrimp in culture pond ecosystem. Indian J. Exp. Biol.
Daşkiran, M., Öno, A. G., Cengiz, Ö., Ünsal, H., Türkyilmaz, S., Tatli, O., & Sevim, O. (2012). Influence of dietary probiotic inclusion on growth performance, blood parameters, and intestinal microflora of male broiler chickens exposed to posthatch holding time. J. Appl. Poult. Res., 21, 612–622. https://doi.org/10.3382/japr.2011-00512
Davis, M. E., Parrott, T., Brown, D. C., de Rodas, B. Z., Johnson, Z. B., Maxwell, C. V., & Rehberger, T. (2008). Effect of a Bacillus-based direct-fed microbial feed supplement on growth performance and pen cleaning characteristics of growing-finishing pigs. Journal of Animal Science, 86, 1459–1467. https://doi.org/10.2527/jas.2007-0603
Dec, M., Puchalski, A., Urban-Chmiel, R., & Wernicki, A. (2014). Screening of Lactobacillus strains of domestic goose origin against bacterial poultry pathogens for use as probiotics. Poultry Science, 93, 2464–2472. https://doi.org/10.3382/ps.2014-04025
Deng, Y., Xu, L., Liu, S., Wang, Q., Guo, Z., Chen, C., & Feng, J. (2020a). What drives changes in the virulence and antibiotic resistance of Vibrio harveyi in the South China Sea? Journal of Fish Diseases. https://doi.org/10.1111/jfd.13197
Deng, Z., Luo, X. M., Liu, J., & Wang, H. (2020b). Quorum sensing, biofilm, and intestinal mucosal barrier: Involvement the role of probiotic. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2020.538077
Desnoyers, M., Giger-Reverdin, S., Bertin, G., Duvaux-Ponter, C., & Sauvant, D. (2009). Meta-analysis of the influence of Saccharomyces cerevisiae supplementation on ruminal parameters and milk production of ruminants. Journal of Dairy Science. https://doi.org/10.3168/jds.2008-1414
Devyatkin, V., Mishurov, A., & Kolodina, E. (2021). Probiotic effect of Bacillus subtilis B-2998D, B-3057D, and Bacillus licheniformis B-2999D complex on sheep and lambs. J. Adv. Vet. Anim. Res., 8, 146–157. https://doi.org/10.5455/javar.2021.h497
Du, R., Jiao, S., Dai, Y., An, J., Lv, J., Yan, X., Wang, J., & Han, B. (2018). Probiotic Bacillus amyloliquefaciens C-1 improves growth performance, stimulates GH/IGF-1, and regulates the gut microbiota of growth-retarded beef calves. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2018.02006
El-Deep, M. H., Dawood, M. A. O., Assar, M. H., & Ahamad Paray, B. (2021). Aspergillus awamori positively impacts the growth performance, nutrient digestibility, antioxidative activity and immune responses of growing rabbits. Vet. Med. Sci., 7, 226–235. https://doi.org/10.1002/vms3.345
El-Sawah, A. A., Aboelhadid, S. M., El-Nahass, E. N., Helal, H. E., Korany, A. M., & El-Ashram, S. (2020). Efficacy of probiotic Enterococcus faecium in combination with diclazuril against coccidiosis in experimentally infected broilers. Journal of Applied Microbiology. https://doi.org/10.1111/jam.14691
El-Sharkawy, H., Tahoun, A., Rizk, A. M., Suzuki, T., Elmonir, W., Nassef, E., Shukry, M., Germoush, M. O., Farrag, F., Bin-Jumah, M., & Mahmoud, A. M. (2020). Evaluation of bifidobacteria and lactobacillus probiotics as alternative therapy for Salmonella typhimurium infection in broiler chickens. Animals. https://doi.org/10.3390/ani10061023
Elghandour, M. M. Y., Tan, Z. L., Abu Hafsa, S. H., Adegbeye, M. J., Greiner, R., Ugbogu, E. A., Cedillo Monroy, J., & Salem, A. Z. M. (2020). Saccharomyces cerevisiae as a probiotic feed additive to non and pseudo-ruminant feeding: A review. Journal of Applied Microbiology. https://doi.org/10.1111/jam.14416
European Parliament and the Council of the European Union. (2003). Regulation (EC) No 1831/2003. Off. J. Eur. Union 4, 29–43.
Fajardo, P., Pastrana, L., Méndez, J., Rodríguez, I., Fucios, C., & Guerra, N. P. (2012). Effects of feeding of two potentially probiotic preparations from lactic acid bacteria on the performance and faecal microflora of broiler chickens. The Scientific World Journal, 2012, 14–16. https://doi.org/10.1100/2012/562635
FAO/WHO. (2002). Guidelines for the evaluation of probiotics in food (Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food). Food Agric. Organ. United Nations World Heal. Organ. https://doi.org/10.1111/j.1469-0691.2012.03873
FAO. (2020). The State of World Fisheries and Aquaculture 2020. Sustainability in action. Nature and Resources. https://doi.org/10.4060/ca9229en
FAO. (2018). GLEAM 2, 2016. Global Livestock Environmental Assessment Model. FAO, Rome,Italy. 82.
FAOSTAT. (2016). Food & Agriculture Organization of the United Nations Statistics Division [WWW Document]. Food Agric. Organ. United Nations Stat. Div.
Fathi, M., Abdelsalam, M., Al-Homidan, I., Ebeid, T., El-Zarei, M., & Abou-Emera, O. (2017). Effect of probiotic supplementation and genotype on growth performance, carcass traits, hematological parameters and immunity of growing rabbits under hot environmental conditions. Animal Science Journal, 88, 1644–1650. https://doi.org/10.1111/asj.12811
Fazelnia, K., Fakhraei, J., Yarahmadi, H. M., & Amini, K. (2021). Dietary supplementation of potential probiotics Bacillus subtilis, Bacillus licheniformis, and Saccharomyces cerevisiae and synbiotic improves growth performance and immune responses by modulation in intestinal system in broiler chicks challenged with Sal. Probiotics Antimicrobial Proteins. https://doi.org/10.1007/s12602-020-09737-5
Forkus, B., Ritter, S., Vlysidis, M., Geldart, K., & Kaznessis, Y. N. (2017). Antimicrobial probiotics reduce Salmonella enterica in Turkey Gastrointestinal Tracts. Science and Reports, 7, 1–9. https://doi.org/10.1038/srep40695
Ghareeb, K., Awad, W. A., Mohnl, M., Porta, R., Biarnés, M., Böhm, J., & Schatzmayr, G. (2012). Evaluating the efficacy of an avian-specific probiotic to reduce the colonization of Campylobacter jejuni in broiler chickens. Poultry Science. https://doi.org/10.3382/ps.2012-02168
Giannenas, I., Papadopoulos, E., Tsalie, E., Triantafillou, E., Henikl, S., Teichmann, K., & Tontis, D. (2012). Assessment of dietary supplementation with probiotics on performance, intestinal morphology and microflora of chickens infected with Eimeria tenella. Veterinary Parasitology. https://doi.org/10.1016/j.vetpar.2012.02.017
Giri, S. S., Sukumaran, V., & Oviya, M. (2013). Potential probiotic Lactobacillus plantarum VSG3 improves the growth, immunity, and disease resistance of tropical freshwater fish, Labeo rohita. Fish Shellfish Immunology. https://doi.org/10.1016/j.fsi.2012.12.008
Gomes, L. C., Brinn, R. P., Marcon, J. L., Dantas, L. A., Brandão, F. R., De Abreu, J. S., Lemos, P. E. M., McComb, D. M., & Baldisserotto, B. (2009). Benefits of using the probiotic Efinol®L during transportation of cardinal tetra, Paracheirodon axelrodi (Schultz), in the Amazon. Aquaculture Research. https://doi.org/10.1111/j.1365-2109.2008.02077.x
Grace, D. (2012). The deadly gifts of livestock: Zoonoses. Agric. Dev.
Gracia, M. I., José, J., & Norel, M. (2013). Effect of probiotic Ecobiol on broiler performance.
Gunasundari, V., Ajith Kumar, T.T., Ghosh, S., Kumaresan, S., 2013. An ex vivo loom to evaluate the brewer’s yeast Saccharomyces cerevisiae in clownfish aquaculture with special reference to Amphiprion percula (Lacepede, 1802). Turkish J. Fish. Aquat. Sci. https://doi.org/10.4194/1303-2712-v13_3_01
Haddadin, M. S. Y., Abdulrahim, S. M., Hashlamoun, E. A. R., & Robinson, R. K. (1996). The effect of Lactobacillus acidophilus on the production and chemical composition of hen’s eggs. Poultry Science. https://doi.org/10.3382/ps.0750491
Haghighi, H. R., Abdul-Careem, M. F., Dara, R. A., Chambers, J. R., & Sharif, S. (2008a). Cytokine gene expression in chicken cecal tonsils following treatment with probiotics and Salmonella infection. Veterinary Microbiology. https://doi.org/10.1016/j.vetmic.2007.06.026
Haghighi, H. R., Abdul-Careem, M. F., Dara, R. A., Chambers, J. R., & Sharif, S. (2008b). Cytokine gene expression in chicken cecal tonsils following treatment with probiotics and Salmonella infection. Veterinary Microbiology, 126, 225–233. https://doi.org/10.1016/j.vetmic.2007.06.026
Hai, N. V. (2015). The use of probiotics in aquaculture. Journal of Applied Microbiology, 119, 917–935. https://doi.org/10.1111/jam.12886
Hai, N. V., Buller, N., & Fotedar, R. (2009a). Effects of probiotics (pseudomonas synxantha and pseudomonas aeruginosa) on the growth, survival and immune parameters of juvenile western king prawns (penaeus latisulcatus kishinouye, 1896). Aquaculture Research. https://doi.org/10.1111/j.1365-2109.2008.02135.x
Han, T., Zhang, Q., Liu, N., Wang, J., Li, Y., Huang, X., Liu, J., Wang, J., Qu, Z., & Qi, K. (2020). Changes in antibiotic resistance of Escherichia coli during the broiler feeding cycle. Poultry Science. https://doi.org/10.1016/j.psj.2020.06.068
Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: Homeostasis and immunopathology. Nutrients. https://doi.org/10.3390/nu5061869
Hashemzadeh, F., Rahimi, S., Amir, M., Torshizi, K., Akbar, A., Torshizi, M.A.K., Akbar, A., 2013. Effects of Probiotics and Antibiotic Supplementation on Serum Biochemistry and Intestinal Microflora in Broiler Chicks. Int. J. Agric. Crop Sci.
Hassoun-Kheir, N., Stabholz, Y., Kreft, J. U., de la Cruz, R., Romalde, J. L., Nesme, J., Sørensen, S. J., Smets, B. F., Graham, D., & Paul, M. (2020). Comparison of antibiotic-resistant bacteria and antibiotic resistance genes abundance in hospital and community wastewater: A systematic review. Science of the Total Environment. https://doi.org/10.1016/j.scitotenv.2020.140804
Hong, H. A., Le, H. D., & Cutting, S. M. (2005). The use of bacterial spore formers as probiotics. FEMS Microbiology Reviews. https://doi.org/10.1016/j.femsre.2004.12.001
Huang, Z., Mu, C., Chen, Y., Zhu, Z., Chen, C., Lan, L., Xu, Q., Zhao, W., & Chen, G. (2015). Effects of dietary probiotic supplementation on LXRα and CYP7α1 gene expression, liver enzyme activities and fat metabolism in ducks. British Poultry Science, 56, 218–224. https://doi.org/10.1080/00071668.2014.1000821
Huddy, R. J., & Coyne, V. E. (2015). Characterisation of the role of an alkaline protease from Vibrio midae SY9 in enhancing the growth rate of cultured abalone fed a probiotic-supplemented feed. Aquaculture. https://doi.org/10.1016/j.aquaculture.2015.05.048
Hughes, D. T., & Sperandio, V. (2008). Inter-kingdom signalling: Communication between bacteria and their hosts. Nature Reviews Microbiology. https://doi.org/10.1038/nrmicro1836
Hung, A.T., Lin, S.Y., Yang, T.Y., Chou, C.K., Liu, H.C., Lu, J.J., Wang, B., Chen, S.Y., Lien, T.F., 2012. Effects of Bacillus coagulans ATCC 7050 on growth performance, intestinal morphology, and microflora composition in broiler chickens. Anim. Prod. Sci. https://doi.org/10.1071/AN11332
Jayaraman, S., Thangavel, G., Kurian, H., Mani, R., Mukkalil, R., & Chirakkal, H. (2013). Bacillus subtilis PB6 improves intestinal health of broiler chickens challenged with Clostridium perfringens-induced necrotic enteritis. Poultry Science. https://doi.org/10.3382/ps.2012-02528
Jin, L. Z., Ho, Y. W., Abdullah, N., Ali, M. A., & Jalaludin, S. (1996). Antagonistic effects of intestinal Lactobacillus isolates on pathogens of chicken. Letters in Applied Microbiology. https://doi.org/10.1111/j.1472-765X.1996.tb00032.x
Jing, W., Liu, Q., & Wang, W. (2020). Bifidobacterium bifidum TMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double-blind control trial. Journal of Food Biochemistry. https://doi.org/10.1111/jfbc.13489
Jouany, J. P., Mathieu, F., Senaud, J., Bohatier, J., Bertin, G., & Mercier, M. (1998). Effect of Saccharomyces cerevisiae and Aspergillus oryzae on the digestion of nitrogen in the rumen of defaunated and refaunated sheep. Animal Feed Science and Technology. https://doi.org/10.1016/S0377-8401(98)00194-1
Kalavathy, R., Abdullah, N., Jalaludin, S., & Ho, Y. W. (2003). Effects of Lactobacillus cultures on growth performance, abdominal fat deposition, serum lipids and weight of organs of broiler chickens. British Poultry Science. https://doi.org/10.1080/0007166031000085445
Kantas, D., Papatsiros, V. G., Tassis, P. D., Giavasis, I., Bouki, P., & Tzika, E. D. (2015). A feed additive containing Bacillus toyonensis (Toyocerin®) protects against enteric pathogens in postweaning piglets. Journal of Applied Microbiology. https://doi.org/10.1111/jam.12729
Kapsenberg, M. L. (2003). Dendritic-cell control of pathogen-driven T-cell polarization. Nature Reviews Immunology. https://doi.org/10.1038/nri1246
Kawai, Y., Ishii, Y., Arakawa, K., Uemura, K., Saitoh, B., Nishimura, J., Kitazawa, H., Yamazaki, Y., Tateno, Y., Itoh, T., & Saito, T. (2004). Structural and functional differences in two cyclic bacteriocins with the same sequences produced by lactobacilli. Applied and Environment Microbiology. https://doi.org/10.1128/AEM.70.5.2906-2911.2004
Kewcharoen, W., Srisapoome, P., 2019. Probiotic effects of Bacillus spp. from Pacific white shrimp (Litopenaeus vannamei) on water quality and shrimp growth, immune responses, and resistance to Vibrio parahaemolyticus (AHPND strains). Fish Shellfish Immunol. https://doi.org/10.1016/j.fsi.2019.09.013
Khaksarzareha, V., Golian, A., Kermanshahi, H., 2012. Immune response and ileal microflora in broilers fed wheat-based diet with or without enzyme Endofeed W and supplementation of thyme essential oil or probiotic PrimaLac®. African J. Biotechnol. https://doi.org/10.5897/AJB12.1237
Khalid, A. H., Ullah, K. S., Naveed, S., Latif, F., Pasha, T. N., Hussain, I., & Qaisrani, S. N. (2021). Effects of spray dried yeast (Saccharomyces cerevisiae) on growth performance and carcass characteristics, gut health, cecal microbiota profile and apparent ileal digestibility of protein, amino acids and energy in broilers. Tropical Animal Health and Production. https://doi.org/10.1007/s11250-021-02684-5
Khattab, A. A. A., El Basuini, M. F. M., El-Ratel, I. T., & Fouda, S. F. (2021). Dietary probiotics as a strategy for improving growth performance, intestinal efficacy, immunity, and antioxidant capacity of white Pekin ducks fed with different levels of CP. Poultry Science, 100, 100898. https://doi.org/10.1016/j.psj.2020.11.067
Kim, S. R., Nonaka, L., & Suzuki, S. (2004). Occurrence of tetracycline resistance genes tet(M) and tet(S) in bacteria from marine aquaculture sites. FEMS Microbiology Letters. https://doi.org/10.1016/j.femsle.2004.06.026
Kong, Y., Gao, C., Du, X., Zhao, J., Li, M., Shan, X., & Wang, G. (2020). Effects of single or conjoint administration of lactic acid bacteria as potential probiotics on growth, immune response and disease resistance of snakehead fish (Channa argus). Fish & Shellfish Immunology. https://doi.org/10.1016/j.fsi.2020.05.003
Krehbiel, C., Rust, S., Zhang, G., & Gilliland, S. (2003). Bacterial direct-fed microbials in ruminant diets: Performance response and mode of action. Journal of Animal Science. https://doi.org/10.2527/2003.8114_suppl_2E120x
Kritas, S. K., Govaris, A., Christodoulopoulos, G., & Burriel, A. R. (2006). Effect of Bacillus licheniformis and Bacillus subtilis supplementation of ewe’s feed on sheep milk production and young lamb mortality. J. Vet. Med. Ser. A Physiol. Pathol. Clin. Med., 53, 170–173. https://doi.org/10.1111/j.1439-0442.2006.00815.x
Kuebutornye, F. K. A., Abarike, E. D., Lu, Y., Hlordzi, V., Sakyi, M. E., Afriyie, G., Wang, Z., Li, Y., & Xie, C. X. (2020). Mechanisms and the role of probiotic Bacillus in mitigating fish pathogens in aquaculture. Fish Physiology and Biochemistry. https://doi.org/10.1007/s10695-019-00754-y
Kurtoglu, V., Kurtoglu, F., Seker, E., Coskun, B., Balevi, T., & Polat, E. S. (2004). Effect of probiotic supplementation on laying hen diets on yield performance and serum and egg yolk cholesterol. Food Additives & Contaminants. https://doi.org/10.1080/02652030310001639530
Lajis, A.F.B., 2020. Biomanufacturing process for the production of bacteriocins from Bacillaceae family. Bioresour. Bioprocess. https://doi.org/10.1186/s40643-020-0295-z
Landy, N., Kavyani, A., 2013. a Multi-Strain Probiotic on Performance, Immune Responses and Cecal Microflora Composition in Broiler Chickens Reared Under Cyclic Heat Stress Condition. Iran. J. Appl. Anim. Sci.
Langenkamp, A., Messi, M., Lanzavecchia, A., & Sallusto, F. (2000). Kinetics of dendritic cell activation: Impact on priming of TH1, TH2 and nonpolarized T cells. Nature Immunology. https://doi.org/10.1038/79758
Lara-Flores, M., Olvera-Novoa, M. A., Guzmán-Méndez, B. E., & López-Madrid, W. (2003). Use of the bacteria Streptococcus faecium and Lactobacillus acidophilus, and the yeast Saccharomyces cerevisiae as growth promoters in Nile tilapia (Oreochromis niloticus). Aquaculture. https://doi.org/10.1016/S0044-8486(02)00277-6
Lei, X., Piao, X., Ru, Y., Zhang, Hongyu, Péron, A., Zhang, Huifang, 2015. Effect of Bacillus amyloliquefaciens-based direct-fed microbial on performance, nutrient utilization, intestinal morphology and cecal microflora in broiler chickens. Asian-Australasian J. Anim. Sci. https://doi.org/10.5713/ajas.14.0330
Leonel Ochoa-Solano, J., & Olmos-Soto, J. (2006). The functional property of Bacillus for shrimp feeds. Food Microbiology. https://doi.org/10.1016/j.fm.2005.10.004
Leyva-Madrigal, K. Y., Luna-González, A., Escobedo-Bonilla, C. M., Fierro-Coronado, J. A., & Maldonado-Mendoza, I. E. (2011). Screening for potential probiotic bacteria to reduce prevalence of WSSV and IHHNV in whiteleg shrimp (Litopenaeus vannamei) under experimental conditions. Aquaculture. https://doi.org/10.1016/j.aquaculture.2011.09.033
Li, P., Gatlin, D.M., 2005. Evaluation of the prebiotic GroBiotic®-A and brewers yeast as dietary supplements for sub-adult hybrid striped bass (Morone chrysops x M. saxatilis) challenged in situ with Mycobacterium marinum, in: Aquaculture. https://doi.org/10.1016/j.aquaculture.2005.03.005
Li, P., Gatlin, D.M., 2004. Dietary brewers yeast and the prebiotic GrobioticTM AE influence growth performance, immune responses and resistance of hybrid striped bass (Morone chrysops x M. saxatilis) to Streptococcus iniae infection. Aquaculture. https://doi.org/10.1016/j.aquaculture.2003.08.021
Li, X. Y., Duan, Y. L., Yang, X., & Yang, X. J. (2020). Effects of Bacillus subtilis and antibiotic growth promoters on the growth performance, intestinal function and gut microbiota of pullets from 0 to 6 weeks. Animal. https://doi.org/10.1017/S1751731120000191
Liao, S. F., & Nyachoti, M. (2017). Using probiotics to improve swine gut health and nutrient utilization. Anim: Nutr. https://doi.org/10.1016/j.aninu.2017.06.007
Lilly, D. M., & Stillwell, R. H. (1965). Probiotics: Growth-promoting factors produced by microorganisms. Science (80). https://doi.org/10.1126/science.147.3659.747
Liu, L., Zeng, D., Yang, M., Wen, B., Lai, J., Zhou, Y., Sun, H., Xiong, L., Wang, J., Lin, Y., Pan, K., Jing, B., Wang, P., & Ni, X. (2019). Probiotic Clostridium butyricum improves the growth performance, immune function, and gut microbiota of weaning rex rabbits. Probiotics Antimicrob. Proteins, 11, 1278–1292. https://doi.org/10.1007/s12602-018-9476-x
Luongo, D., Miyamoto, J., Bergamo, P., Nazzaro, F., Baruzzi, F., Sashihara, T., Tanabe, S., & Rossi, M. (2013). Differential modulation of innate immunity in vitro by probiotic strains of Lactobacillus gasseri. BMC Microbiology. https://doi.org/10.1186/1471-2180-13-298
Ma, Z. Z., Cheng, Y. Y., Wang, S. Q., Ge, J. Z., Shi, H. P., & Kou, J. C. (2020). Positive effects of dietary supplementation of three probiotics on milk yield, milk composition and intestinal flora in Sannan dairy goats varied in kind of probiotics. Journal of Animal Physiology and Animal Nutrition (berlin). https://doi.org/10.1111/jpn.13226
Maas, R. M., Verdegem, M. C. J., Debnath, S., Marchal, L., & Schrama, J. W. (2021). Effect of enzymes (phytase and xylanase), probiotics (B. amyloliquefaciens) and their combination on growth performance and nutrient utilisation in Nile tilapia. Aquaculture. https://doi.org/10.1016/j.aquaculture.2020.736226
Maldonado Galdeano, C., Cazorla, S. I., Lemme Dumit, J. M., Vélez, E., & Perdigón, G. (2019). Beneficial effects of probiotic consumption on the immune system. Annals of Nutrition & Metabolism, 74, 115–124. https://doi.org/10.1159/000496426
Marques, A., Thanh, T. H., Sorgeloos, P., & Bossier, P. (2006). Use of microalgae and bacteria to enhance protection of gnotobiotic Artemia against different pathogens. Aquaculture. https://doi.org/10.1016/j.aquaculture.2006.04.021
Marshall, B. M., & Levy, S. B. (2011). Food animals and antimicrobials: Impacts on human health. Clinical Microbiology Reviews. https://doi.org/10.1128/CMR.00002-11
Mathieu, F., Jouany, J. P., Sénaud, J., Bohatier, J., Bertin, G., & Mercier, M. (1996). The effect of Saccharomyces cerevisiae and Aspergillus oryzae on fermentations in the rumen of faunated and defaunated sheep; protozoal and probiotic interactions. Reproduction, Nutrition, Development. https://doi.org/10.1051/rnd:19960305
Mellman, I., & Steinman, R. M. (2001). Dendritic cells: Specialized and regulated antigen processing machines. Cell. https://doi.org/10.1016/S0092-8674(01)00449-4
Midhun, S. J., Neethu, S., Arun, D., Vysakh, A., Divya, L., Radhakrishnan, E. K., & Jyothis, M. (2019). Dietary supplementation of Bacillus licheniformis HGA8B improves growth parameters, enzymatic profile and gene expression of Oreochromis niloticus. Aquaculture. https://doi.org/10.1016/j.aquaculture.2019.02.064
Miller, M. B., & Bassler, B. L. (2001). Quorum sensing in bacteria. Annual Review of Microbiology. https://doi.org/10.1146/annurev.micro.55.1.165
Mo, W. Y., Choi, W. M., Man, K. Y., & Wong, M. H. (2020). Food waste-based pellets for feeding grass carp (Ctenopharyngodon idellus): Adding baker’s yeast and enzymes to enhance growth and immunity. Science of the Total Environment. https://doi.org/10.1016/j.scitotenv.2019.134954
Mohammed, A. A., Zaki, R. S., Negm, E. A., Mahmoud, M. A., & Cheng, H. W. (2021). Effects of dietary supplementation of a probiotic (Bacillus subtilis) on bone mass and meat quality of broiler chickens. Poultry Science. https://doi.org/10.1016/j.psj.2020.11.073
Mohanty S. K.,Tripathi, S. D., & Swai, S. N. (1996). Rearing of catla (Catla catla Ham.) spawn on formulated diets. J. AQUACULT. TROP. .
Mookiah, S., Sieo, C. C., Ramasamy, K., Abdullah, N., & Ho, Y. W. (2014). Effects of dietary prebiotics, probiotic and synbiotics on performance, caecal bacterial populations and caecal fermentation concentrations of broiler chickens. Journal of the Science of Food and Agriculture. https://doi.org/10.1002/jsfa.6365
Moriarty, D. J. W. (1998). Control of luminous Vibrio species in penaeid aquaculture ponds. Aquaculture. https://doi.org/10.1016/S0044-8486(98)00199-9
Morishita, T. Y., Aye, P. P., Harr, B. S., Cobb, C. W., & Clifford, J. R. (1997). Evaluation of an avian-specific probiotic to reduce the colonization and shedding of Campylobacter jejuni in Broilers. Avian Diseases. https://doi.org/10.2307/1592338
Mountzouris, K. C., Balaskas, C., Xanthakos, I., Tzivinikou, A., & Fegeros, K. (2009). Effects of a multi-species probiotic on biomarkers of competitive exclusion efficacy in broilers challenged with Salmonella enteritidis. British Poultry Science. https://doi.org/10.1080/00071660903110935
Mountzouris, K. C., Tsitrsikos, P., Palamidi, I., Arvaniti, A., Mohnl, M., Schatzmayr, G., & Fegeros, K. (2010). Effects of probiotic inclusion levels in broiler nutrition on growth performance, nutrient digestibility, plasma immunoglobulins, and cecal microflora composition. Poultry Science. https://doi.org/10.3382/ps.2009-00308
Muya, M. C., Nherera, F. V., Miller, K. A., Aperce, C. C., Moshidi, P. M., & Erasmus, L. J. (2015). Effect of Megasphaera elsdenii NCIMB 41125 dosing on rumen development, volatile fatty acid production and blood β-hydroxybutyrate in neonatal dairy calves. Journal of Animal Physiology and Animal Nutrition (berlin). https://doi.org/10.1111/jpn.12306
Naas, K. E., Næss, T., & Harboe, T. (1992). Enhanced first feeding of halibut larvae (Hippoglossus hippoglossus L.) in green water. Aquaculture. https://doi.org/10.1016/0044-8486(92)90126-6
Nocek, J. E., & Kautz, W. P. (2006). Direct-fed microbial supplementation on ruminal digestion, health, and performance of pre- and postpartum dairy cattle. Journal of Dairy Science. https://doi.org/10.3168/jds.S0022-0302(06)72090-2
Noor, Z., Noor, M., Khan, I., & Khan, S. A. (2020). Evaluating the lucrative role of probiotics in the aquaculture using microscopic and biochemical techniques. Microscopy Research and Technique, 83, 310–317. https://doi.org/10.1002/jemt.23416
Ohya, T., Marubashi, T., & Ito, H. (2000). Significance of fecal volatile fatty acids in shedding of Escherichia coli O157 from calves: experimental infection and preliminary use of a probiotic product. Journal of Veterinary Medical Science, 62, 1151–1155. https://doi.org/10.1292/jvms.62.1151
Olmos, J., Acosta, M., Mendoza, G., & Pitones, V. (2020). Bacillus subtilis, an ideal probiotic bacterium to shrimp and fish aquaculture that increase feed digestibility, prevent microbial diseases, and avoid water pollution. Archives of Microbiology, 202, 427–435. https://doi.org/10.1007/s00203-019-01757-2
Panda, A. K., Reddy, M. R., Rama Rao, S. V., & Praharaj, N. K. (2003). Production performance, serum/yolk cholesterol and immune competence of White Leghorn layers as influenced by dietary supplementation with probiotic. Tropical Animal Health and Production. https://doi.org/10.1023/A:1022036023325
Park, S. C., Shimamura, I., Fukunaga, M., Mori, K. I., & Nakai, T. (2000). Isolation of bacteriophages specific to a fish pathogen, Pseudomonas plecoglossicida, as a candidate for disease control. Applied and Environment Microbiology. https://doi.org/10.1128/AEM.66.4.1416-1422.2000
Park, Y. H., Hamidon, F., Rajangan, C., Soh, K. P., Gan, C. Y., Lim, T. S., Abdullah, W. N. W., & Liong, M. T. (2016). Application of probiotics for the production of safe and high-quality poultry meat. Korean Journal for Food Science of Animal Resources, 36, 567–576. https://doi.org/10.5851/kosfa.2016.36.5.567
Pedroso, A. A., Hurley-Bacon, A. L., Zedek, A. S., Kwan, T. W., Jordan, A. P. O., Avellaneda, G., Hofacre, C. L., Oakley, B. B., Collett, S. R., Maurer, J. J., & Lee, M. D. (2013). Can probiotics improve the environmental microbiome and resistome of commercial poultry production? International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph10104534
Pérez-Cano, F. J., Dong, H., & Yaqoob, P. (2010). In vitro immunomodulatory activity of Lactobacillus fermentum CECT5716 and Lactobacillus salivarius CECT5713: Two probiotic strains isolated from human breast milk. Immunobiology. https://doi.org/10.1016/j.imbio.2010.01.004
Pietras, M. (2001). The effect of probiotics on selected blood and meat parameters of broiler chickens. J Anim Feed Sci. https://doi.org/10.22358/jafs/70112/2001
Plaza-Diaz, J., Ruiz-Ojeda, F. J., Gil-Campos, M., & Gil, A. (2019). Mechanisms of action of probiotics. Advances in Nutrition, 10, S49–S66. https://doi.org/10.1093/advances/nmy063
Punetha, M., Roy, A. K., Ajithakumar, H. M., Para, I. A., Gupta, D., Singh, M., & Bharati, J. (2018). Immunomodulatory effects of probiotics and prilled fat supplementation on immune genes expression and lymphocyte proliferation of transition stage Karan Fries cows. Vet World. https://doi.org/10.14202/vetworld.2018.209-214
Rahman, M. S., Mustari, A., Salauddin, M., & Rahman, M. M. (2013). Effects of probiotics and enzymes on growth performance and haematobiochemical parameters in broilers. J. Bangladesh Agril. Univ, 11, 111–118.
Rajput, D. S., Zeng, D., Khalique, A., Rajput, S. S., Wang, H., Zhao, Y., Sun, N., & Ni, X. (2020). Pretreatment with probiotics ameliorate gut health and necrotic enteritis in broiler chickens, a substitute to antibiotics. AMB Express. https://doi.org/10.1186/s13568-020-01153-w
Ramesh, D., Vinothkanna, A., Rai, A. K., & Vignesh, V. S. (2015). Isolation of potential probiotic spp and assessment of their subcellular components to induce immune responses in Labeo rohita against Aeromonas hydrophila. Fish & Shellfish Immunology. https://doi.org/10.1016/j.fsi.2015.04.018
Redweik, G. A. J., Stromberg, Z. R., Van Goor, A., & Mellata, M. (2020). Protection against avian pathogenic Escherichia coli and Salmonella Kentucky exhibited in chickens given both probiotics and live Salmonella vaccine. Poultry Science, 99, 752–762. https://doi.org/10.1016/j.psj.2019.10.038
Reitan, K. I., Rainuzzo, J. R., Øie, G., & Olsen, Y. (1997). A review of the nutritional effects of algae in marine fish larvae. Aquaculture. https://doi.org/10.1016/S0044-8486(97)00118-X
Rizzo, A., Fiorentino, M., Buommino, E., Donnarumma, G., Losacco, A., & Bevilacqua, N. (2015). Lactobacillus crispatus mediates anti-inflammatory cytokine interleukin-10 induction in response to Chlamydia trachomatis infection in vitro. International Journal of Medical Microbiology. https://doi.org/10.1016/j.ijmm.2015.07.005
Russo, P., Arena, M. P., Fiocco, D., Capozzi, V., Drider, D., & Spano, G. (2017). Lactobacillus plantarum with broad antifungal activity: A promising approach to increase safety and shelf-life of cereal-based products. International Journal of Food Microbiology. https://doi.org/10.1016/j.ijfoodmicro.2016.04.027
Sato, K., Takahashi, K., Tohno, M., Miura, Y., Kamada, T., Ikegami, S., & Kitazawa, H. (2009). Immunomodulation in gut-associated lymphoid tissue of neonatal chicks by immunobiotic diets. Poultry Science. https://doi.org/10.3382/ps.2009-00291
Seo, J. K., Kim, S. W., Kim, M. H., Upadhaya, S. D., Kam, D. K., & Ha, J. K. (2010). Direct-fed microbials for ruminant animals. Asian-Australasian Journal of Animal Sciences: Asian-Australasian Association of Animal Production Societies. https://doi.org/10.5713/ajas.2010.r.08
Sharma, A. N., Kumar, S., & Tyagi, A. K. (2018). Effects of mannan-oligosaccharides and Lactobacillus acidophilus supplementation on growth performance, nutrient utilization and faecal characteristics in Murrah buffalo calves. Journal of Animal Physiology and Animal Nutrition (berlin), 102, 679–689. https://doi.org/10.1111/jpn.12878
Shim, Y. H., Ingale, S. L., Kim, J. S., Kim, K. H., Seo, D. K., Lee, S. C., Chae, B. J., & Kwon, I. K. (2012). A multi-microbe probiotic formulation processed at low and high drying temperatures: Effects on growth performance, nutrient retention and caecal microbiology of broilers. British Poultry Science. https://doi.org/10.1080/00071668.2012.690508
Signorini, M. L., Soto, L. P., Zbrun, M. V., Sequeira, G. J., Rosmini, M. R., & Frizzo, L. S. (2012). Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria. Research in Veterinary Science. https://doi.org/10.1016/j.rvsc.2011.05.001
Skjermo, J., & Vadstein, O. (1999). Techniques for microbial control in the intensive rearing of marine larvae. Aquaculture. https://doi.org/10.1016/S0044-8486(99)00096-4
Sobczak, A., & Kozłowski, K. (2015). The effect of a probiotic preparation containing Bacillus subtilis ATCC PTA-6737 on egg production and physiological parameters of laying hens. Ann. Anim. Sci., 15, 711–723. https://doi.org/10.1515/aoas-2015-0040
Soltani, M., Ghosh, K., Hoseinifar, S. H., Kumar, V., Lymbery, A. J., Roy, S., & Ringø, E. (2019). Genus bacillus, promising probiotics in aquaculture: Aquatic animal origin, bio-active components, bioremediation and efficacy in fish and shellfish. Rev Fish Sci Aquac. https://doi.org/10.1080/23308249.2019.1597010
Sun, K., Xie, C., Xu, D., Yang, X., Tang, J., & Ji, X. (2013). Lactobacillus isolates from healthy volunteers exert immunomodulatory effects on activated peripheral blood mononuclear cells. Journal of Biomedical Research. https://doi.org/10.7555/JBR.27.20120074
Supamattaya, K., Kiriratnikom, S., Boonyaratpalin, M., & Borowitzka, L. (2005). Effect of a Dunaliella extract on growth performance, health condition, immune response and disease resistance in black tiger shrimp (Penaeus monodon). Aquaculture. https://doi.org/10.1016/j.aquaculture.2005.04.014
Surendran Nair, M., Amalaradjou, M. A., & Venkitanarayanan, K. (2017). Antivirulence properties of probiotics in combating microbial pathogenesis. Advances in Applied Microbiology. https://doi.org/10.1016/bs.aambs.2016.12.001
Taherpour, K., Moravej, H., Shivazad, M., Adibmoradi, M., & Yakhchali, B. (2009). Effects of dietary probiotic, prebiotic and butyric acid glycerides on performance and serum composition in broiler chickens. African J Biotechnol. https://doi.org/10.4314/ajb.v8i10.60590
Tanwar, J., Das, S., Fatima, Z., & Hameed, S. (2014). Multidrug resistance: An emerging crisis. Interdiscip Perspect Infect Dis. https://doi.org/10.1155/2014/541340
Taoka, Y., Maeda, H., Jo, J. Y., Jeon, M. J., Bai, S. C., Lee, W. J., Yuge, K., & Koshio, S. (2006). Growth, stress tolerance and non-specific immune response of Japanese flounder Paralichthys olivaceus to probiotics in a closed recirculating system. Fisheries Science. https://doi.org/10.1111/j.1444-2906.2006.01152.x
Taras, D., Vahjen, W., Macha, M., & Simon, O. (2005). Response of performance characteristics and fecal consistency to long-lasting dietary supplementation with the probiotic strain Bacillus cereus var. toyoi to sows and piglets. Archives of Animal Nutrition. https://doi.org/10.1080/17450390500353168
Tellez, G., Pixley, C., Wolfenden, R. E., Layton, S. L., & Hargis, B. M. (2012). Probiotics/direct fed microbials for Salmonella control in poultry. Food Research International. https://doi.org/10.1016/j.foodres.2011.03.047
Terada, T., Nii, T., Isobe, N., & Yoshimura, Y. (2020). Effects of probiotics Lactobacillus reuteri and Clostridium butyricum on the expression of toll-like receptors, pro- and anti-inflammatory cytokines, and antimicrobial peptides in broiler chick intestine. The Journal of Poultry Science. https://doi.org/10.2141/jpsa.0190098
United Nations Department of Economic and Social Affairs Population Division. (2017). World Population Prospects: The 2017 Revision. World Popul. Prospect.
Upadhaya, S. D., Rudeaux, F., & Kim, I. H. (2019). Efficacy of dietary Bacillus subtilis and Bacillus licheniformis supplementation continuously in pullet and lay period on egg production, excreta microflora, and egg quality of Hyline-Brown birds. Poultry Science. https://doi.org/10.3382/ps/pez184
Uyeno, Y., Shigemori, S., & Shimosato, T. (2015). Effect of probiotics/prebiotics on cattle health and productivity. Microbes and Environments. https://doi.org/10.1264/jsme2.ME14176
Van Doan, H., Hoseinifar, S. H., Tapingkae, W., Seel-audom, M., Jaturasitha, S., Dawood, M. A. O., Wongmaneeprateep, S., Thu, T. T. N., & Esteban, M. Á. (2020). Boosted growth performance, mucosal and serum immunity, and disease resistance Nile Tilapia (Oreochromis niloticus) Fingerlings Using Corncob-Derived Xylooligosaccharide and Lactobacillus plantarum CR1T5. Probiotics Antimicrobial Proteins. https://doi.org/10.1007/s12602-019-09554-5
van Hai, N., Buller, N., & Fotedar, R. (2010). Effect of customized probiotics on the physiological and immunological responses of juvenile western king prawns (Penaeus latisulcatus Kishinouye, 1896) challenged with Vibrio harveyi. Journal of Applied Aquaculture. https://doi.org/10.1080/10454438.2010.527580
Van Hai, N., Buller, N., & Fotedar, R. (2009b). The use of customised probiotics in the cultivation of western king prawns (Penaeus latisulcatus Kishinouye, 1896). Fish & Shellfish Immunology. https://doi.org/10.1016/j.fsi.2009.05.004
van Zyl, W. F., Deane, S. M., & Dicks, L. M. T. (2020). Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria. Gut Microbes. https://doi.org/10.1080/19490976.2020.1831339
Waiyamitra, P., Zoral, M. A., Saengtienchai, A., Luengnaruemitchai, A., Decamp, O., Gorgoglione, B., & Surachetpong, W. (2020). Probiotics modulate tilapia resistance and immune response against tilapia lake virus infection. Pathogens, 9, 1–15. https://doi.org/10.3390/pathogens9110919
Wang, C., Chang, T., Yang, H., & Cui, M. (2015). Antibacterial mechanism of lactic acid on physiological and morphological properties of Salmonella enteritidis, Escherichia coli and Listeria monocytogenes. Food Control. https://doi.org/10.1016/j.foodcont.2014.06.034
Wang, L., Li, L., Lv, Y., Chen, Q., Feng, J., & Zhao, X. (2018). Lactobacillus plantarum Restores Intestinal Permeability Disrupted by Salmonella Infection in Newly-hatched Chicks. Science Reports. https://doi.org/10.1038/s41598-018-20752-z
Wang, R., Guo, Z., Tang, Y., Kuang, J., Duan, Y., Lin, H., Jiang, S., Shu, H., & Huang, J. (2020). Effects on development and microbial community of shrimp Litopenaeus vannamei larvae with probiotics treatment. AMB Express. https://doi.org/10.1186/s13568-020-01041-3
Wang, Y., & He, Z. (2009). Effect of probiotics on alkaline phosphatase activity and nutrient level in sediment of shrimp, Penaeus vannamei, ponds. Aquaculture. https://doi.org/10.1016/j.aquaculture.2008.10.022
Wang, Y. B. (2007). Effect of probiotics on growth performance and digestive enzyme activity of the shrimp Penaeus vannamei. Aquaculture. https://doi.org/10.1016/j.aquaculture.2007.05.035
Wang, Y. B., Xu, Z. R., & Xia, M. S. (2005). The effectiveness of commercial probiotics in northern white shrimp Penaeus vannamei ponds. Fisheries Science. https://doi.org/10.1111/j.1444-2906.2005.01061.x
Wanja, D. W., Mbuthia, P. G., Waruiru, R. M., Bebora, L. C., Ngowi, H. A., & Nyaga, P. N. (2020). Antibiotic and disinfectant susceptibility patterns of bacteria isolated from farmed fish in Kirinyaga County Kenya. International Journal of Microbiology. https://doi.org/10.1155/2020/8897338
Waters, C. M., & Bassler, B. L. (2005). QUORUM SENSING: Cell-to-cell communication in bacteria. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.21.012704.131001
Weimer, P. J. (2015). Redundancy, resilience, and host specificity of the ruminal microbiota: Implications for engineering improved ruminal fermentations. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2015.00296
Wideman, R. F., Hamal, K. R., Stark, J. M., Blankenship, J., Lester, H., Mitchell, K. N., Lorenzoni, G., & Pevzner, I. (2012). A wire-flooring model 1 for inducing lameness in broilers: Evaluation of probiotics as a prophylactic treatment. Poultry Science, 91, 870–883. https://doi.org/10.3382/ps.2011-01907
Wlodarska, M., Willing, B., Keeney, K. M., Menendez, A., Bergstrom, K. S., Gill, N., Russell, S. L., Vallance, B. A., & Finlay, B. B. (2011). Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis. Infection and Immunity. https://doi.org/10.1128/IAI.01104-10
Wu, R., Shen, J., Tian, D., Yu, J., He, T., Yi, J., & Li, Y. (2020). A potential alternative to traditional antibiotics in aquaculture: Yeast glycoprotein exhibits antimicrobial effect in vivo and in vitro on Aeromonas caviae isolated from Carassius auratus gibelio. Vetnary Medcine Science. https://doi.org/10.1002/vms3.253
Xiang, Q., Wang, C., Zhang, H., Lai, W., Wei, H., & Peng, J. (2019). Effects of different probiotics on laying performance, egg quality, oxidative status, and gut health in laying hens. Animals. https://doi.org/10.3390/ani9121110
Xu, J., Li, Y., Yang, Z., Li, C., Liang, H., Wu, Z., & Pu, W. (2018). Yeast probiotics shape the gut microbiome and improve the health of early-weaned piglets. Frontiers in Microbiology, 9, 1–11. https://doi.org/10.3389/fmicb.2018.02011
Xu, T., Chen, Y., Yu, L., Wang, J., Huang, M., & Zhu, N. (2020). Effects of Lactobacillus plantarum on intestinal integrity and immune responses of egg-laying chickens infected with Clostridium perfringens under the free-range or the specific pathogen free environment. BMC Veterinary Research. https://doi.org/10.1186/s12917-020-2264-3
Yang, Y., Latorre, J. D., Khatri, B., Kwon, Y. M., Kong, B. W., Teague, K. D., Graham, L. E., Wolfenden, A. D., Mahaffey, B. D., Baxter, M., Hernandez-Velasco, X., Merino-Guzman, R., Hargis, B. M., & Tellez, G. (2018). Characterization and evaluation of lactic acid bacteria candidates for intestinal epithelial permeability and Salmonella typhimurium colonization in neonatal Turkey poults. Poultry Science, 97, 515–521. https://doi.org/10.3382/ps/pex311
Yildirim, Z., & Johnson, M. G. (1998). Characterization and antimicrobial spectrum of bifidocin B, a bacteriocin produced by Bifidobacterium bifidum NCFB 1454. Journal of Food Protection. https://doi.org/10.4315/0362-028X-61.1.47
Yousefi, M., & Karkoodi, K. (2007). Effect of probiotic thepax® and Saccharomyces cerevisiae supplementation on performance and egg quality of laying hens. International Journal of Poultry Science. https://doi.org/10.3923/ijps.2007.52.54
Yulianto, A.B., Lokapirnasari, W.P., Najwan, R., Wardhani, H.C.P., Rahman, N.F.N., Huda, K., Ulfah, N., 2020. Influence of lactobacillus casei WB 315 and crude fish oil (CFO) on growth performance, EPA, DHA, HDL, LDL, cholesterol of meat broiler chickens. Iran. J. Microbiol. DOI: https://doi.org/10.18502/ijm.v12i2.2620
Zhang, C. N., Zhang, J. L., Guan, W. C., Zhang, X. F., Guan, S. H., Zeng, Q. H., Cheng, G. F., & Cui, W. (2017). Effects of Lactobacillus delbrueckii on immune response, disease resistance against Aeromonas hydrophila, antioxidant capability and growth performance of Cyprinus carpio Huanghe var. Fish & Shellfish Immunology. https://doi.org/10.1016/j.fsi.2017.07.012
Zhang, H., Wang, H., Shepherd, M., Wen, K., Li, G., Yang, X., Kocher, J., Giri-Rachman, E., Dickerman, A., Settlage, R., & Yuan, L. (2014). Probiotics and virulent human rotavirus modulate the transplanted human gut microbiota in gnotobiotic pigs. Gut Pathology. https://doi.org/10.1186/s13099-014-0039-8
Zhang, J. L., Xie, Q. M., Ji, J., Yang, W. H., Wu, Y. B., Li, C., Ma, J. Y., & Bi, Y. Z. (2012). Different combinations of probiotics improve the production performance, egg quality, and immune response of layer hens. Poultry Science, 91, 2755–2760. https://doi.org/10.3382/ps.2012-02339
Zhang, L., Zhang, R., Jia, H., Zhu, Z., Li, H., & Ma, Y. (2021). Supplementation of probiotics in water beneficial growth performance, carcass traits, immune function, and antioxidant capacity in broiler chickens. Open Life Science, 16, 311–322. https://doi.org/10.1515/biol-2021-0031
Zhang, Z. F., & Kim, I. H. (2014). Effects of multistrain probiotics on growth performance, apparent ileal nutrient digestibility, blood characteristics, cecal microbial shedding, and excreta odor contents in broilers. Poultry Science. https://doi.org/10.3382/ps.2013-03314
Zhao, X., Guo, Y., Guo, S., & Tan, J. (2013). Effects of Clostridium butyricum and Enterococcus faecium on growth performance, lipid metabolism, and cecal microbiota of broiler chickens. Applied Microbiology and Biotechnology, 97, 6477–6488. https://doi.org/10.1007/s00253-013-4970-2
Zhitnitsky, D., Rose, J., & Lewinson, O. (2017). The highly synergistic, broad spectrum, antibacterial activity of organic acids and transition metals. Science Reports. https://doi.org/10.1038/srep44554
Zulkifli, I., Abdullah, N., & Mohd. Azrin, N., Ho, Y.W.,. (2000). Growth performance and immune response of two commercial broiler strains fed diets containing Lactobacillus cultures and oxytetracycline under heat stress conditions. British Poultry Science. https://doi.org/10.1080/713654979
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Anee, I.J., Alam, S., Begum, R.A. et al. The role of probiotics on animal health and nutrition. JoBAZ 82, 52 (2021). https://doi.org/10.1186/s41936-021-00250-x
- Animal health