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The role of probiotics on animal health and nutrition

Abstract

Background

The constant global need for food has created a demand for colossal food production. Every day the world requires more food than it is capable of growing and harvesting. Antibiotics have been used in healthy food products to promote growth and prevent disease in food-producing animals for a long time. This prolonged use of antibiotics leads to the development of resistant bacteria and the accumulation of antibiotic residue in livestock and fish. To avoid further causalities finding an effective alternative became a dire need. At present, the most suitable alternative for antibiotics is probiotics.

Main body

Probiotics are live microorganisms that provide health benefits when consumed or applied to the body with the optimum amount. Probiotics are mainly good bacteria and yeast which fight off the pathogenic bacteria, improve the immune system, and restore the gut microbial balance. Probiotics can eliminate the harmful pathogens following several molecular mechanisms and modulate the immune response of the host animal for the well-being of the animals. This review article aims to describe probiotics as a potential growth promoter in major food sectors (poultry, ruminant, and aquaculture), how probiotics can ensure food safety without harmful effects on animals, and find out some points where more research is required to ensure a positive outcome.

Conclusion

The conclusion of this review article highlights the knowledge gaps and how they can be minimized using modern molecular technologies to establish probiotic supplements as an effective alternative to antibiotics.

Background

The world population is increasing rapidly. It is assumed to extend to over 9.8 billion people by 2050, United Nations Department of Economic and Social Affairs Population Division (2017). This growing population is imposing food security challenges worldwide. Livestock farming is one of the rapidly expanding agricultural sectors. Generally, 75% of rural people and 25% of urban people rely on livestock for their sustenance, Grace (2012). Aquaculture is also developing as a primary agribusiness sector for the ever-increasing global human population. This sector has been advancing swiftly due to the enhanced cultivation methods in inland water bodies Hai (2015).

To maintain the enormous need for meat and fish production, veterans and farmers use antibiotics in the veterinary sector as antimicrobial growth promoters (AGPs) (Li et al., 2020; Marshall & Levy, 2011). The setback here is that it comes with harmful consequences. People use feed antibiotics as sub-therapeutic drugs for animal growth, but excessive and improper antibiotic use can develop antibiotic resistance in microbial populations (Deng et al., 2020a, 2020b; Han et al., 2020). This unnatural use of antibiotics has turned out into a public concern because of its affiliation with human and animal disorders. Later, the EU Regulation (EC) No 1831/2003 prohibited the unauthorized sale of dietary additives, including probiotics, without precisely labeling the product with an exact name and well-functioning group additives. The regulation also stated that the manufacturing company responsible for producing the supplements should mention the name, net weight, and net volume of the specific product appropriately. The product must also have the manufacturing date, including batch number and related information for product usage. The EU regulation also affirmed that companies could only authorize coccidiostats or histomonostats type antibiotics that might serve as dietary supplements, European Parliament and the Council of the European Union (2003).

Apart from antibiotic-caused illness, various foodborne pathogenic bacteria can cause major zoonotic diseases such as salmonellosis, campylobacteriosis, and pathogenic Escherichia coli infection in humans. These outbreaks create public health concerns and economic loss around the world. To face the current challenge of producing vast amounts of livestock and fish, probiotics have been found to improve animals' quality and growth without causing adverse effects.

Lilly and Stillwell (1965) first used the word probiotic as the opposite of the word antibiotic. By definition, probiotics are microbial substances capable of stimulating the expansion of another microorganism. Afterward, Fuller AFRC (1989) improved the description significantly, which was pretty near the definition used today. Fuller AFRC (1989) addressed probiotics as alive microbial feed additives that promisingly improve the host animals' intestinal microbial balance. FAO/WHO (2002) provided the current definition of probiotics which affirms that probiotics are active microbes that offer health values for the host animal when appropriately supplemented.

Probiotics can eliminate the pathogenic microorganisms from the GIT and change the host's microbial population density in the intestinal tract. Probiotics subsequently establish a better suited microbial population through a transformation in the equilibrium of beneficial and noxious microorganisms (Mountzouris et al., 2009). After probiotics settle in the gut, it prompts an immunologic response. The intestinal cells can assemble a series of immunoregulatory molecules exhilarated by bacteria (Corcionivoschi et al., 2010). Some probiotic metabolites can modulate various metabolic pathways in cells. Probiotic metabolic components such as bacteriocins, amines, and hydrogen peroxide interact with specific targets of multiple metabolic pathways to regulate apoptosis, cell proliferation, inflammation, and differentiation (Plaza-Diaz et al., 2019).

Nowadays, farmers provide probiotic feed supplements to poultry, ruminants, and fishes. Probiotics are mostly gram-positive bacteria but there are also gram-negative bacteria, yeast, and fungi. The most common probiotics used for animals (Table 1) incorporate Lactobacillus, Bifidobacterium, Lactococcus, Bacillus, Streptococcus, and yeast, such as Candida and saccharomyces (Arora, 2020; Park et al., 2016).

Table 1 A diverse range of microorganisms commonly used as probiotics in animal

Probiotics have inaugurated a new era in health administration for animals. This study aims to analyze the role of probiotics on animal health and determine the prospects of sustainable probiotics utilization in this sector.

Main text

Mode of action of probiotics

Probiotics exert their effectiveness through diverse mechanisms. Probiotics inhibit and control enteric pathogens along with improving the functioning and production capacity of animals. Basic probiotic mode of action includes (a) inhibition of pathogen adhesion; (b) production of antimicrobial components, i.e., bacteriocins and defensins; (c) competitive exclusion of pathogenic microorganisms; (d) enhancement of barrier function; (e) reduction of luminal pH; and (f) modulation of the immune system (Fig. 1). Probiotics promote health conditions by inhibiting harmful bacteria. For instance, Lactobacillus rhamnosus and Lactobacillus plantarum can avert Escherichia coli adhesion in the intestinal tract (Maldonado Galdeano et al., 2019). Bacteria commonly interact with host cells following the secretion of chemical signals that influence bacterial organisms' approach (Miller & Bassler, 2001; Waters & Bassler, 2005). This communicating technique of bacteria with its host is called quorum sensing (Chen et al., 2020a, 2020b; Deng et al., 2020a, 2020b; Hughes & Sperandio, 2008). Probiotics can influence pathogenicity by modifying the communication process in pathogenic bacteria. Probiotics produce antibacterial substances and impede bacterial adherence and translocation. Lactobacillus, Leuconostoc, Pediococcus, Lactococcus, Enterococcus, Streptococcus, and Bifidobacteria can yield proteins or bacteriocins that minimize the development of closely linked bacterial organisms. These probiotics reduce the number of detrimental microorganisms from the gastrointestinal tract (Kawai et al., 2004; Yildirim & Johnson, 1998). Bacteriocins are bioactive antimicrobic peptides generated in the ribosome of many bacteria and stick to the pathogenic microorganism cells penetrating through the phospholipid membranes. The basic pattern of bacteriocin-mediated pathogen reaction encloses the cytoplasmic membrane penetration of pathogenic bacteria that confers in DNA and RNA synthesis inhibition and cell leakages (van Zyl et al., 2020). Bacteriocins can restrict pathogen cells' capability of GIT colonization and combat antibiotic-resistant strains of bacteria (Kuebutornye et al., 2020; Lajis, 2020). The following figure provides a streamlined illustration of the basic mechanisms of action of probiotics (Fig. 1).

Fig. 1
figure1

Probiotic mode of action. These include six proposed mechanisms: a Inhibition of pathogen adhesion. Probiotics improve the growth rate against pathogenic microbes by suppressing pathogenic growth and diminishing pathogenic adhesion in the gastrointestinal (GI) tract. b Secretion of defensins/bacteriocins. Probiotics can intensify antimicrobial protein secretion like defensins to eliminate pathogens. c Competitive exclusion of pathogenic microorganisms. Probiotics can rigorously compete with intestinal harmful microbes to prohibit detrimental colonization by binding with receptors in the IEC or mucus layer. d Enhancement of barrier function. Probiotics can improve mucin glycoproteins secretion by the mucus-producing cells to yield a dense mucus layer that helps to decrease intracellular permeability to pathogens. e Reduction of luminal pH. Probiotics lessen the pH level of the lumen by triggering acetic acid production which is deadly to other pathogens. f Modulation of the immune system. Probiotics modulate innate immunity and adaptive immunity by T and B-cell activation through the dendritic cell in the mucosa. Dendritic cell is found in the mucosal lamina propria, surface epithelium and Peyer's patches. The M-cells are highly specific epithelial cells and they take up probiotics in the Peyer’s patches. Dendritic cells supply them to the mesenteric lymph node where the T-cells and antibody-producing B-cells are produced

Probiotic microbes can withstand pathogenic bacteria by lowering luminal pH. Probiotic Bifidobacterium breve can lower the luminal pH. Bifidobacterium breve can trigger acetic acid production in higher concentrations in a deadly Shiga toxin-yielding Escherichia coli O157:H7 mouse experimental model (Asahara et al., 2004). Probiotics can shape the cell–cell communication of bacteria and host and maintain cellular consistency by strengthening the intestinal barrier function. Such consistency is achieved through the modulation of cytoskeletal and tight junctional protein phosphorylation. Lactobacillus can abide by the epithelial cells of the ileum of chickens (Jin et al., 1996). Probiotics can competitively exclude pathogenic microorganisms from the host intestine by strengthening this intestinal communication system (Mookiah et al., 2014). This anti-pathogenic mechanism (competitive exclusion) demonstrates that bacterial species rigidly battle for attaching to receptors at particular binding sites in the GIT and might integrate antimicrobial substances secretion and competition for accessible nutrients (van Zyl et al., 2020).

Probiotics can improve the immunity of the host by modulating the immune system. The consumed probiotics play a crucial role in stimulating the mucosal immune system (MIS) and induce a network of signals. The reaction of diverse probiotic microbes on dendritic cells (DC) has been investigated in different experimental approaches. Dendritic cells are antigen-displaying cells that have crucial roles in innate and adaptive immunity. Dendritic cells can identify and react to bacterial components besides launching primary immune responses, which lead to the straight development of T- and B-cell responses. Probiotics can directly govern intestinal dendritic cells with pathogen recognition patterns (PRPs) displayed on the surface, which can precisely recognize the pathogen-associated molecular patterns (PAMPs) on the bacterial organism. This acknowledging method stimulates DC maturation regarding up-regulation of co-stimulatory molecular expression. As the immune system becomes active, cytokine secretion incites T-cell activation (Langenkamp et al., 2000; Mellman & Steinman, 2001). DC-originated signals ascertain the type of T-cells responses such as T helper cells polarization or T regulatory response, which determines the B-cell responses against pathogenicity, Kapsenberg (2003).

Probiotics increase digestibility

Probiotics increase the rate of digestion in animals. Probiotics can ameliorate cecal microorganism constitution and nutrient digestion in broilers (Khalid et al., 2021). Probiotics boost the ileal digestibility of essential amino acids, with a 5 percent enhancement in chicken body weight, Zhang and Kim (2014) and can ameliorate the bioaccumulation of calcium in poultry (Chawla et al., 2013). (Maas et al., 2021) experimented with enzymes xylanase, phytase together with probiotics. They reported the impact of Bacillus amyloliquefaciens on digestion or metabolism and found better calcium absorption and improved microorganisms’ interactions in the gut.

Probiotics increase enzyme activity in the GIT and improve the digestibility of the food eaten by the host. For example, a study in buffalo calves showed that probiotic feed containing Lactobacillus acidophilus could ensure more dry matter intake, daily feed conversion efficiency, and apparent digestibility of nutrients compared to the control group (Sharma et al., 2018).

Probiotics improve the immune system

Probiotics can enhance immunity in the host in many ways. Multiple studies have proven the immunostimulatory properties of probiotics (Bilal et al., 2021; Kong et al., 2020; Punetha et al., 2018; Terada et al., 2020). Probiotics comprising Lactobacillus fermentum and Saccharomyces cerevisiae excited the gut T-cell immunity, highlighted by the enhanced yield of CD3+, CD4+, and CD8+ T-lymphocytes in the gastrointestinal tract of chickens (Bai et al., 2013). In neonatal chicks of three-day- and seven-day-old expression of CD3+, IL-2, and IFN-γ-genes were higher in the small intestine when provided food with probiotics Lactobacillus jensenii TL2937 and Lactobacillus gasseri TL2919 than without probiotics (Sato et al., 2009).

Probiotics can also boost serum immunoglobulin levels in chickens. A probiotic feed supplement containing Lactobacillus acidophilus, Bacillus subtilis, and Clostridium butyricum enhanced IgA and IgM serum levels in chickens, Zhang and Kim (2014).

The LAB (Lactic Acid Bacteria) can generate a broad range of antimicrobial compounds to reduce pathogenic attacks. These include antimicrobial peptides (AMPs), such as defensins, organic acids, bacteriocins, ethanol, carbon dioxide, and diacetyl, Liao and Nyachoti (2017). Organic acids like short-chain fatty acids, formic acids, and lactic acid have been proved to suppress potential harmful microbes of importance in farm animals. Lactobacillus bacteria can generate lactic acid as the main glucose metabolism product (Russo et al., 2017). Organic acids work on the bacterial cell wall, cytoplasmic membrane, and precise metabolic functions such as replication and protein synthesis, which lead to the destruction and death of pathogenic microorganisms (Surendran Nair et al., 2017; Zhitnitsky et al., 2017). Salmonella Enteritidis, Lactobacillus monocytogenes, and Escherichia coli could be effectively inactivated after exposure to 0.5% lactic acid for two hours (Wang et al., 2015).

Probiotics can influence both the innate and adaptive immunity of the host. Several immune cell types, comprising granulocytes, dendritic cells, macrophages, T lymphocytes, and B lymphocytes, are engaged with inflammatory responses, which are regulated by cytokines like TNFα, IL-8, IL-1β, IL-15, and IL-6 interleukins. The anti-inflammatory reactions are mediated by TGFβ, IL-10, IL-12 (Hardy et al., 2013). Innate immunity provides physical and chemical barriers against pathogens for the host organism. For example, intestinal epithelial cells (IECs) prevent the spread of harmful microbes so that infections don not occur. It has been reported that Lactobacillus bacteria such as Lactobacillus gasseri, Lactobacillus salivarius, Lactobacillus fermentum, and Lactobacillus crispatus can regulate favorably the secretion level of the pro- and anti-inflammatory interleukins IL-6, IL-8, and IL-10 to manage the inflammation and rebuild the physiological balance in animals (Luongo et al., 2013; Pérez-Cano et al., 2010; Rizzo et al., 2015; Sun et al., 2013). Lactobacillus delbrueckii strain can stimulate anti-inflammatory properties and capable of downregulating the pro-inflammatory cytokines IL-8 levels. These inflammatory responses were seen in Aeromonas hydrophila contaminated carp (Cyprinus carpio Huanghe var.) when supplemented with 1 × 107 CFU g/L Lactobacillus delbrueckii probiotics (Zhang et al., 2017). The adaptive immune response is dependent on B-lymphocytes and T-lymphocytes, which stimulate an antigen-specific response. In poultry, feed supplementation with 1 × 109 CFU/kg of Lactobacillus acidophilus LA5 elevated the amount of CD8+, CD4+, TCR1+ T-cell in the gastrointestinal tract as well as in the peripheral blood system (Asgari et al., 2016).

Role of probiotics in poultry

The world's poultry production now is five times higher than the poultry production of 50 years ago, FAOSTAT (2016). Evaluation from the 2016 "Global Livestock Environmental Assessment Model" FAO (2018) discloses that around 73 million tons of eggs and approximately 100 million tons of poultry meat have been required worldwide. Probiotics can help to meet this massive need without exerting harmful effects (Fig. 2).

Fig. 2
figure2

A flowchart containing an informative summary of beneficial effects of probiotics in animals (poultry, ruminants, and aquaculture)

Probiotics can improve the growth rates of broiler chicken (Abd El-Hack et al., 2020; Afsharmanesh & Sadaghi, 2014; Lei et al., 2015; Mookiah et al., 2014; Zhang & Kim, 2014). Probiotics can prevent gastrointestinal diseases like salmonellosis (Biloni et al., 2013; El-Sharkawy et al., 2020; Fazelnia et al., 2021; Tellez et al., 2012); necrotic enteritis (Jayaraman et al., 2013; Rajput et al., 2020; Xu et al., 2020); as well as coccidiosis (El-Sawah et al., 2020). Broiler chickens fed with Lactobacillus acidophilus, Lactobacillus casei, and Bifidobacterium at about 1 percent of the food amount comprising over 5 × 109 CFU/g can improve the chickens' growth rate, immune system, and antioxidant quantity (Zhang et al., 2021).

Probiotics can modify the histology of the intestinal mucosa of poultry. The intestinal mucosa framework is a crucial factor for both digestive and absorptive intestinal function and affects the poultry's growth. The villus height and the villus-to-crypt ratio of intestinal mucus layer were enhanced by Bacillus subtilis (Afsharmanesh & Sadaghi, 2014; Jayaraman et al., 2013); Bacillus coagulans (Hung et al., 2012), Lactobacillus salivarius, Pediococcus parvulus (Biloni et al., 2013), and Enterococcus faecium (Abdel-Rahman et al., 2013; Cao et al., 2013). Along with the improvement in villus height and villus height-to-crypt ratio, the assimilation of nutrients also increases owing to a greater surface area, Afsharmanesh and Sadaghi (2014). The use of Lactobacillus sakei Probio-65 ameliorated villi height likewise crypt depth in the jejunum of broiler chicken compared with chickens supplemented with or without antibiotics (Wlodarska et al., 2011).

Probiotics can prevent salmonellosis in chickens. Hatched chicks that were vaccinated with 1 × 109 CFU Lactobacillus plantarum LTC-113 strain can prevent salmonellosis. Lactobacillus plantarum can limit the gut colonization of harmful bacteria and stabilize the expression of tight junction genes in gut epithelial cells, thus make the chickens better tolerant of the infection (Wang et al., 2018). As broiler chickens get affected by APEC and Salmonella, the latest research indicated that when probiotics and RASV are provided in a combination for the White leghorn chickens that can decrease the rate of infection in leghorn chickens (Redweik et al., 2020). Bacillus licheniformis and Bacillus subtilis containing feed supplement can reduce the shedding of Escherichia coli in laying hens (Upadhaya et al., 2019).

Campylobacteriosis is another major illness of poultry caused by Campylobacter jejuni. In chicken, in vitro experiments with probiotic bacterial strains such as Pediococcus acidilactici, Lactobacillus reuteri, Enterococcus faecium, and Lactobacillus salivarius showed that the probiotics could impede the growth of Campylobacter jejuni (Ghareeb et al., 2012). Feeding the artificially infected chicken a commercial mixture of probiotic Lactobacillus acidophilus and Enterococcus faecium decreased the shedding of Campylobacter by 70 percent and the gut colonization of Campylobacter by 27 percent (Morishita et al., 1997).

Coccidiosis is another crucial parasitic disease of poultry resulting from a protozoan, Eimeria. Eimeria colonizes the intestinal tract. When probiotics supplementation is provided including Bifidobacterium animalis, Enterococcus faecium, Bacillus subtilis, and Lactobacillus reuteri, either individually or in combination, it can lower down the infection rate (Giannenas et al., 2012).

Probiotics improve the laying performance of hens and egg quality. Lohmann pink laying hens which are nourished with Clostridium butyricum, Saccharomyces boulardii, and pediococcus acidilactici have improved the gastrointestinal state and egg quality (Xiang et al., 2019). When brown laying hens are given Bacillus subtilis ATCC PTA- 6737 at 1 × 108 CFU/kg feed, the laid eggs have better yolk color, albumen quality, shell thickness, and breaking strength than the eggs laid by control group hens, Sobczak and Kozłowski (2015). Probiotics can efficiently minimize the egg yolk cholesterol level. Bacillus spores, lactic acid bacteria, and yeast can minimize the cholesterol level of the egg yolk (Haddadin et al., 1996; Kurtoglu et al., 2004; Panda et al., 2003; Yousefi, & Karkoodi, 2007).

Probiotics improve the meat quality of the chicken. Bacillus subtilis can upgrade chicken meat quality (Mohammed et al., 2021). Bifidobacterium bifidum and Bacillus toyonensis can enhance the growth rate and meat quality in quails (Abou-Kassem et al., 2021). Lactobacillus casei can elevate the high-density lipoprotein (HDL) level and mitigate the low-density lipoprotein (LDL) level in broiler chicken (Yulianto et al., 2020). Lactobacillus acidophilus together with Streptococcus faecium enhances the protein amount in meat by lowering high-density lipoprotein cholesterol levels and plasma protein concentrations, Pietras (2001). Additional works based on Lactobacillus spp. supplementation offered similar results, with minimization in the whole cholesterol levels and low-density lipoprotein cholesterol levels (Kalavathy et al., 2003; Taherpour et al., 2009), as well as triglycerides level in blood serum of broilers (Kalavathy et al., 2003).

Probiotics provide immunomodulatory responses. Probiotics supplementation helps broiler chickens to cope up with stress conditions. Lactic acid bacteria (LAB) probiotics addition as a food supplement can rectify heat-stress-relevant diseases in chickens (Abd El-Hack et al., 2020). Lactic acid bacteria can improve antibody production (Zulkifli et al., 2000). Probiotics can enhance immunity by increasing the Toll-like receptor (TLR) signaling. Toll-like receptor (TLR) plays a crucial role in the activation of T-cells in the intestinal immune system (Asgari et al., 2018). Lactobacillus fermentum and Saccharomyces cerevisiae can strengthen the degree of mRNA expression of TLR-2 and TLR-4 in the foregut of the chickens in respect of those treated with or without an antibiotic (Bai et al., 2013).

Role of probiotics in ruminants

The rumen has an intricate microbial population. Host animals ingest carbohydrates and proteins, which are degraded by rumen microorganisms. The commonly used probiotics for ruminants are Saccharomyces cerevisiae (Chaucheyras-Durand et al., 2008; Elghandour et al., 2020), Lactic acid bacteria (LAB) (Chiquette et al., 2008; Weimer, 2015); Aspergillus oryzae (Jouany et al., 1998; Mathieu et al., 1996); Bacillus and Enterococcus (Uyeno et al., 2015) which confer significant well-being for the ruminant health (Fig. 2).

Probiotics can enhance milk production in dairy cattle. Probiotic microorganisms such as Bacillus sublitis, Saccharomyces cerevisiae, and Enterococcus faecalis can enrich milk secretion (Ma et al., 2020), and also Bifidobacterium bifidum can inhibit milk allergy reaction (Jing et al., 2020). Cows supplemented with 5 × 109 CFU of Enterococcus faecium and 2 × 109 CFU Saccharomyces cerevisiae cells enhanced milk production by 2.3 L per cow each day, Nocek and Kautz (2006). A rigorous quantitative study on yeast probiotics' implications in ruminants demonstrated that ruminants fed with active yeast probiotics increased milk production by nearly 1.2 g/kg of body weight. Dry matter intake (DMI) by the farm animals was elevated nearly 0.44 g/kg of bodyweight though there was no effect on milk protein amount (Desnoyers et al., 2009).

Probiotics can increase the ruminants' body weight. For instance, a probiotic combination of Lactobacillus reuteri DDL 19, Lactobacillus alimentarius DDL 48, Enterococcus faecium DDE 39, and Bifidobacterium bifidum DDBA collected from a fine goat and fed to other goats for about two months. This caused an improvement in the goat's standard bodyweight by nine percent (Apás et al., 2010). Bacillus subtilis and Bacillus amyloliquefaciens can upgrade intestinal maturation and growth competency by stimulating GH/IGF-1 hormone (Du et al., 2018).

Probiotics can increase food digestibility in ruminants. Using a mixture of Lactobacillus acidophilus NP51 and Propionibacterium freudenreichii NP24 as cow feed has improved the digestion of neutral detergent fiber, crude protein, and milk yield by nearly 7.6 percent (Boyd et al., 2011).

Probiotics can enhance the immune system in ruminants. The supplementation of Lactobacillus acidophilus, Lactobacillus salivarius, and Lactobacillus plantarum at a pace of 107–108 CFU/g bring down the occurrence of diarrhea in juvenile calves (Signorini et al., 2012). Nisin is an antimicrobial peptide generated from Lactococcus lactis. Nisin infusion in the intra-mammary gland can treat mastitis, which is caused by Staphylococcus aureus in dairy cows (Cao et al., 2007). Lactobacillus base teat spray can improve mammary gland condition and strengthen the functions of the teat sphincter (Alawneh et al., 2020). Probiotics supplementation can alleviate rumen acidosis in cows and improve immunity in young stressed calves (Krehbiel et al., 2003).

Probiotics can strengthen rumen fermentation. Multiple probiotic strains have been proved to yield antimicrobial components that can decrease zoonotic pathogens and control ammonia production. Rhodopseudomonas palustris, a photosynthetic bacteria, have been considered a feasible probiotic in the animal feed sector (Chen et al., 2020a, 2020b) reported that Rhodopseudomonas palustris containing feed supplements can promote the viability of rumen microorganisms. They also noticed that Rhodopseudomonas palustris addition rendered high growth performance of rumen microorganisms and increased microbial fermentation to keep up the microbial balance. Application of Megasphaera elsdenii can ameliorate butyrate production and improve dietary intake in newborn calves (Muya et al., 2015).

Role of probiotics in aquaculture

In 2018, universal fish production was around 179 million tons, coupled with a total sale value estimated at USD 401 billion, FAO (2020). Antibiotics are extensively used to meet the increasing demand in aquaculture. However, this extensive use of antibiotics gives rise to the drug-resistant bacteria that transmit through the food web to human (Cabello, 2006; Da Costa et al., 2013; Hassoun-Kheir et al., 2020; Kim et al., 2004; Tanwar et al., 2014; Wanja et al., 2020).

Probiotics confer several beneficial effects to aqua-animals (Fig. 2). Probiotics promote the growth and reproduction of water-dwelling animals, safeguard from pathogens, strengthen immunity, help in digestion, improve water quality, and work as an alternative to antibiotics, Banerjee and Ray (2017).

Farmers use a broad range of probiotics in fish farming. Bacillus subtilis from Bacillus genera is frequently used in aquaculture (Hong et al., 2005; Olmos et al., 2020). Bacillus probiotics alone can mitigate various harmful microorganisms in fish such as Vibrio, Pseudomonas, Aeromonas, Clostridium, Streptococcus, Flavobacterium, Acinetobacter, and white spot syndrome virus (Kuebutornye et al., 2020). Other bacterial strains commonly used as probiotics in aquaculture are the LAB bacteria such as Lactococcus lactis (Balcázar et al., 2007) and Lactobacillus plantarum VSG-3 (Giri et al., 2013). A broad range of Gram-negative bacteria performs a vital role in fish farming. Several microalgae such as Dunaliella tertiolecta, Dunaliella salina, Isochrysis galbana, Phaeodactylum tricornutum, and Tetraselmis suecica have enhanced the development and survival rate of aquatic animals (Cahu et al., 1998; Marques et al., 2006; Naas et al., 1992; Reitan et al., 1997; Supamattaya et al., 2005). Yeast (Saccharomyces cerevisiae) has been proven useful for aquatic animals (Mo et al., 2020; Wu et al., 2020).

Farmers supply the fishes with probiotic feed supplement either through water circulation or dietary supplements (Moriarty, 1998; Skjermo & Vadstein, 1999). A single bacterial strain or a combination of several bacterial strains can be used as probiotics along with other prebiotics or immunostimulants (Hai et al., 2009a, 2009b). Achieving expected outcomes in fish culture depends on the proper dosage and timing.

Probiotics improve the health conditions of fish and other water-dwelling creatures Bacillus pumilus (Aly et al., 2008) and Lactobacillus plantarum (Van Doan et al., 2020) can ameliorate the health conditions of Nile tilapia. To mitigate the adverse impact of the Tilapia Lake Virus, dietary supplements of 1 percent Bacillus spp were given orally for the red hybrid Tilapia fishes (Waiyamitra et al., 2020). This feed supplement can reduce the fatality rate by Lake Virus infection. Probiotic Pseudomonas I-2 can inhibit disease-causing vibrio microorganisms (Chythanya et al., 2002). Probiotic Pediococcus acidilactici can resist vibriosis in white leg shrimp (Castex et al., 2008). Feeding White leg shrimp larvae with a variety of probiotic feed supplements (Lactobacillus, Saccharomyces, Bacillus, effective microorganisms such as gram-positive cocci and Bifidobacterium, and Photosynthetic Bacteria) can accelerate the growth speed and larval metamorphosis. It also encumbers incomplete molting during the development and minimizes the number of vibrio pathogens (Wang et al., 2020). Pediococcus pentosaceus and Staphylococcus hemolyticus can decrease the frequency of white spot syndrome virus in white leg prawns (Leyva-Madrigal et al., 2011). Saccharomyces cerevisiae can be used as a substitute for live food in the cultivation of clownfish (Gunasundari et al., 2013); Catla (Mohanty S.K.; Tripathi, S.D., 1996); hybrid striped bass (Li & Gatlin, 2004, 2005); Japanese flounder (Taoka et al., 2006) and Nile tilapia (Lara-Flores et al., 2003). Bifidobacterium animalis and Lactobacillus acidophilus-rich feed additives can ennoble the growth and lifespan of Hypophthalmichthys molitrix fingerlings (Noor et al., 2020).

Probiotics can enhance immune responses in fish. Bacillus activates the humoral and cell-mediated immunologic response in fish (Kuebutornye et al., 2020). Bacillus pumilus and Bacillus licheniformis strengthen the immunity of Nile tilapia (Aly et al., 2008) and Bacillus pumilus improves the immunity of rohu fish (Ramesh et al., 2015). Bacillus licheniformis assists in performing the immunomodulatory activities and raises Oreochromis niloticus production by up-regulating the Toll-like receptors (TLR-2) and anti-inflammatory cytokines (Midhun et al., 2019).

Probiotics can improve growth performance, feed intake, and digestive enzyme processes in aquatic animals. Probiotics generate extracellular enzymes such as protease, carbohydrase, and lipase and efficiently engage in the nutrient digestion of aquatic animals (Arellano-Carbajal & Olmos-Soto, 2002; Leonel Ochoa-Solano & Olmos-Soto, 2006). Bacillus generates different hydrolytic enzymes such as β-1,3-glucanases, proteases, and cellulases to improve the digestion in fish (Kuebutornye et al., 2020). In a sea snail, Haliotis midae, the probiotic Vibrio midae SY9 can reinforce digestive protease activity, protein digestion, and growth rate activities, Huddy and Coyne (2015). Bacillus spp. and photosynthetic bacteria can improve white leg prawns' growth through an increase in lipase and cellulase activity, Wang (2007). Pseudomonas aeruginosa and Pseudomonas synxantha can enhance the growth rate of western king prawns (van Hai et al., 2010, van Hai et al., 2009a, 2009b).

Probiotics can improve water quality. Probiotics have shown their potency in nourishing water properties, controlling disease, and thus upgrading fish habitat (Chen et al., 2020a, 2020b; Kewcharoen & Srisapoome, 2019; Soltani et al., 2019). Probiotics enhance water quality by reducing the number of harmful microbes (Dalmin et al., 2001; Park et al., 2000), mitigate nitrogen (Wang et al., 2005) and reduce phosphate contamination in the sediments, Wang and He (2009). Probiotics can alleviate metabolic wastes at the time of the fish school's transportation, cardinal tetra (Paracheirodon axelrodi) (Gomes et al., 2009).

Use of probiotics on miscellaneous animals

Probiotic feed supplements confer health values in farm animals such as sheep, lamb, pigs, rabbits, ducks, and turkeys. Scientists worldwide proposed different probiotic feed additives for the safe production of meat, egg, and milk maintaining these animals well-being. Probiotics can improve the health condition of sheep and lambs. Bacillus licheniformis and Bacillus subtilis can improve body weight, upgrade the intestinal microbiome, boost immunity, and preserve regular metabolic actions in two-month-old sheep and lambs (Devyatkin et al., 2021).

Probiotics can improve milk quality in ewes. Feed supplements including Bacillus subtilits and Bacillus licheniformis can lower mortality, improve milk protein content, and increase the production of milk in ewes (Kritas et al., 2006).

Probiotics can ameliorate the health condition of birds. When white Pekin ducks were given a dietary feed supplement containing Lactobacillus acidophilus and Lactobacillus casei that increased total weight gain, protein content, intestinal enzyme activity, bactericidal activity, and decreased cholesterol, glucose, and cortisol level (Khattab et al., 2021). Lactobacillus can produce lactic acid and reduce pathogenic infection maintaining intestinal microorganism balance in geese (Dec et al., 2014). In Cherry Valley Pekin ducks, Bacillus subtilis and Bacillus licheniformis can enhance LXRα and CYP7α1 enzyme activities in the liver and reduce lipid concentrations and fat deposition (Huang et al., 2015).

In neonatal turkey birds, lactic acid bacteria can fight back against Salmonella enteritis and Clostridium jejuni and improve GIT condition (Yang et al., 2018). Modified probiotic bacteria, Escherichia coli Nissle 1917, can secrete the antimicrobial peptide, Microcin J25 which diminishes Salmonella enteritidis in GIT of turkey (Forkus et al., 2017).

Probiotics can improve the health condition of rabbits. Clostridium butyricum can improve growth rate, gut microbial condition, and intestinal immunity in Rex rabbits. When healthy female rabbits were fed with Clostridium butyricum, it considerably ameliorated body weight, the action of digestive enzyme, improved the immune system by enhancing the abundance of beneficial bacteria (Liu et al., 2019). Bacillus subtilis containing feed supplements can improve growth performance, meat quality, and immune response in rabbits brought up in a heated environment (Fathi et al., 2017). Growing rabbits fed with Aspergillus awamori demonstrated improved body weight, nutrient digestibility, and better antioxidative responses (El-Deep et al., 2021).

Probiotics can improve the health status of pigs. Bacillus amyloliquefaciens is considered a useful dietary supplement against antibiotics in pigs and piglets for fattening (Cao et al., 2020). Pigs face much trouble during weaning which leads to immune and intestinal system malfunctions, upsets the gut microbial environment, and hampers the growth rate of piglets. Duan-Nai-An, an engineered Saccharomyces cerevisiae strain, can significantly improve body weight, feed intake, and decrease the rate of diarrhea and death in early-weaned piglets (Xu et al., 2018).

Conclusions

The world is being densely populated day by day. To meet the need for meat and fish production of this ever-growing population, some effective yet harmless solutions became a crying need. Probiotics have a vital role to solve this food production problem and replace the harmful antibiotic use in farm industries. Nonetheless, every unique probiotic cannot be guaranteed to provide safety with conventional strains. Some probiotics might have undesirable properties such as transmittable antimicrobial resistance, virulence factors, hemolytic potential, and unwanted yield of toxic biochemical substances. To avoid any causalities, distinct probiotic strains must be determined for individual species in a particular environment. The efficiency and reactions for every probiotic are dissimilar. So, the optimum condition for a probiotic to survive, colonize, expand, and render its effects to the hosts in a particular environment needs to be identified.

Modern molecular methods such as quorum sensing, different staining methods, polymerase chain reaction (PCR), scanning electron microscope, fluorescent in situ hybridization (FISH), and genome-wide association study (GWAS) could be applied. Implementing these techniques will successively help to find out the detail about the adherence and colonization of probiotic and pathogenic bacteria, interaction with the host and breeding environment, the communication process between probiotics and host mucosa, gene exchange or transfer horizontally or vertically. Proper knowledge of the immune-modulatory effects of different probiotics and their viability before probiotics which are added in farm animals' dietary feed is essential. Moreover, dosage-dependent studies should be done in greater detail by confirming the organism's identity using molecular testing at a reference laboratory. Additional investigations are required before providing guidelines for probiotics with any degree of confidence.

Availability of data and materials

Not Applicable.

Abbreviations

GIT:

Gastric Intestinal Tract

IgA:

Immunoglobin A

IgM:

Immunoglobin M

TNFα:

Tumor necrosis factor alpha

TGFβ:

Transforming growth factor beta

IFNγ:

Interferon gamma

IL:

Interleukin

TcR:

T-cell receptor

IEC:

Intestinal epithelial cell

GH:

Growth hormone

IGF-1:

Insulin-like growth factor 1

APEC:

Avian pathogenic Escherichia coli

RASV:

Recombinant attenuated Salmonella vaccines

CD:

Cluster of differentiation

CFU:

Colony-forming unit

References

  1. Abd El-Hack, M. E., El-Saadony, M. T., Shafi, M. E., Qattan, S. Y. A., Batiha, G. E., Khafaga, A. F., Abdel-Moneim, A. M. E., & Alagawany, M. (2020). Probiotics in poultry feed: A comprehensive review. Journal of Animal Physiology and Animal Nutrition (berlin), 104, 1835–1850. https://doi.org/10.1111/jpn.13454

    CAS  Article  Google Scholar 

  2. Abdel-Rahman, H. A., Shawky, S. M., Ouda, H., Nafeaa, A. A., & Orabi, S. H. (2013). Effect of two probiotics and bioflavonoids supplementation to the broilers diet and drinking water on the growth performance and hepatic antioxidant parameters. Global Vet. https://doi.org/10.5829/idosi.gv.2013.10.6.7459

    Article  Google Scholar 

  3. Abou-Kassem, D. E., Elsadek, M. F., Abdel-Moneim, A. E., Mahgoub, S. A., Elaraby, G. M., Taha, A. E., Elshafie, M. M., Alkhawtani, D. M., Abd El-Hack, M. E., & Ashour, E. A. (2021). Growth, carcass characteristics, meat quality, and microbial aspects of growing quail fed diets enriched with two different types of probiotics (Bacillus toyonensis and Bifidobacterium bifidum). Poultry Science. https://doi.org/10.1016/j.psj.2020.04.019

    Article  PubMed  Google Scholar 

  4. Adami, A., & Cavazzoni, V. (1999). Occurrence of selected bacterial groups in the faeces of piglets fed with Bacillus coagulans as probiotic. Journal of Basic Microbiology, 39, 3–9. https://doi.org/10.1002/(SICI)1521-4028(199903)39:1%3c3::AID-JOBM3%3e3.0.CO;2-O

    CAS  Article  PubMed  Google Scholar 

  5. AFRC, R.F.,. (1989). Probiotics in man and animals. Journal of Applied Bacteriology. https://doi.org/10.1111/j.1365-2672.1989.tb05105.x

    Article  Google Scholar 

  6. Afsharmanesh, M., & Sadaghi, B. (2014). Effects of dietary alternatives (probiotic, green tea powder, and Kombucha tea) as antimicrobial growth promoters on growth, ileal nutrient digestibility, blood parameters, and immune response of broiler chickens. Computation Clinical Path. https://doi.org/10.1007/s00580-013-1676-x

    Article  Google Scholar 

  7. Alawneh, J. I., James, A. S., Phillips, N., Fraser, B., Jury, K., Soust, M., & Olchowy, T. W. J. (2020). Efficacy of a Lactobacillus-based teat spray on udder health in lactating dairy cows. Frontiers Veterinary Science, 7, 1–9. https://doi.org/10.3389/fvets.2020.584436

    Article  Google Scholar 

  8. Alexopoulos, C., Georgoulakis, I. E., Tzivara, A., Kritas, S. K., Siochu, A., & Kyriakis, S. C. (2004). Field evaluation of the efficacy of a probiotic containing Bacillus licheniformis and Bacillus subtilis spores, on the health status and performance of sows and their litters. Journal of Animal Physiology and Animal Nutrition (berlin). https://doi.org/10.1111/j.1439-0396.2004.00492.x

    Article  Google Scholar 

  9. Aly, S. M., Mohamed, M. F., & John, G. (2008). Effect of probiotics on the survival, growth and challenge infection in Tilapia nilotica (Oreochromis niloticus). Aquaculture Research. https://doi.org/10.1111/j.1365-2109.2008.01932.x

    Article  Google Scholar 

  10. Apás, A. L., Dupraz, J., Ross, R., González, S. N., & Arena, M. E. (2010). Probiotic administration effect on fecal mutagenicity and microflora in the goat’s gut. Journal of Bioscience and Bioengineering. https://doi.org/10.1016/j.jbiosc.2010.06.005

    Article  PubMed  Google Scholar 

  11. Arellano-Carbajal, F., & Olmos-Soto, J. (2002). Thermostable α-1,4- and α-1,6-glucosidase enzymes from Bacillus sp. isolated from a marine environment. World Journal of Microbiology and Biotechnology. https://doi.org/10.1023/A:1020433210432

    Article  Google Scholar 

  12. Arora, N. K. (2020). Advances in probiotics for sustainable food and medicine.

  13. Asahara, T., Shimizu, K., Nomoto, K., Hamabata, T., Ozawa, A., & Takeda, Y. (2004). Probiotic bifidobacteria protect mice from lethal infection with Shiga toxin-producing Escherichia coli O157:H7. Infection and Immunity. https://doi.org/10.1128/IAI.72.4.2240-2247.2004

    Article  PubMed  PubMed Central  Google Scholar 

  14. Asgari, F., Falak, R., Teimourian, S., Pourakbari, B., Ebrahimnezhad, S., & Shekarabi, M. (2018). Effects of oral probiotic feeding on toll-like receptor gene expression of the chicken’s cecal tonsil. Reports Biochemistry and Molecular Biology.

  15. Asgari, F., Madjd, Z., Falak, R., Bahar, M. A., Heydari Nasrabadi, M., Raiani, M., & Shekarabi, M. (2016). Probiotic feeding affects T cell populations in blood and lymphoid organs in chickens. Benef Microbes. https://doi.org/10.3920/BM2016.0014

    Article  PubMed  Google Scholar 

  16. Bai, S. P., Wu, A. M., Ding, X. M., Lei, Y., Bai, J., Zhang, K. Y., & Chio, J. S. (2013). Effects of probiotic-supplemented diets on growth performance and intestinal immune characteristics of broiler chickens. Poultry Science. https://doi.org/10.3382/ps.2012-02813

    Article  PubMed  Google Scholar 

  17. Balcázar, J. L., Rojas-Luna, T., & Cunningham, D. P. (2007). Effect of the addition of four potential probiotic strains on the survival of pacific white shrimp (Litopenaeus vannamei) following immersion challenge with Vibrio parahaemolyticus. Journal of Invertebrate Pathology. https://doi.org/10.1016/j.jip.2007.04.008

    Article  PubMed  Google Scholar 

  18. Banerjee, G., & Ray, A. K. (2017). The advancement of probiotics research and its application in fish farming industries. Research in Veterinary Science, 115, 66–77. https://doi.org/10.1016/j.rvsc.2017.01.016

    CAS  Article  PubMed  Google Scholar 

  19. Benmechernene, Z., Chentouf, H. F., Yahia, B., Fatima, G., Quintela-Baluja, M., Calo-Mata, P., & Barros-Velázquez, J. (2013). Technological aptitude and applications of leuconostoc mesenteroides bioactive strains isolated from algerian raw camel milk. Biomedical Research International. https://doi.org/10.1155/2013/418132

    Article  Google Scholar 

  20. Bilal, M., Si, W., Barbe, F., Chevaux, E., Sienkiewicz, O., & Zhao, X. (2021). Effects of novel probiotic strains of Bacillus pumilus and Bacillus subtilis on production, gut health, and immunity of broiler chickens raised under suboptimal conditions. Poultry Science. https://doi.org/10.1016/j.psj.2020.11.048

    Article  PubMed  Google Scholar 

  21. Biloni, A., Quintana, C. F., Menconi, A., Kallapura, G., Latorre, J., Pixley, C., Layton, S., Dalmagro, M., Hernandez-Velasco, X., Wolfenden, A., Hargis, B. M., & Tellez, G. (2013). Evaluation of effects of EarlyBird associated with FloraMax-B11 on Salmonella enteritidis, intestinal morphology, and performance of broiler chickens. Poultry Science. https://doi.org/10.3382/ps.2013-03279

    Article  PubMed  Google Scholar 

  22. Boyd, J., West, J. W., & Bernard, J. K. (2011). Effects of the addition of direct-fed microbials and glycerol to the diet of lactating dairy cows on milk yield and apparent efficiency of yield. Journal of Dairy Science. https://doi.org/10.3168/jds.2010-3984

    Article  PubMed  Google Scholar 

  23. Cabello, F. C. (2006). Heavy use of prophylactic antibiotics in aquaculture: A growing problem for human and animal health and for the environment. Environmental Microbiology. https://doi.org/10.1111/j.1462-2920.2006.01054.x

    Article  PubMed  Google Scholar 

  24. Cahu, C. L., Zambonino Infante, J. L., Péres, A., Quazuguel, P., & Le Gall, M. M. (1998). Algal addition in sea bass (Dicentrarchus labrax) larvae rearing: Effect on digestive enzymes. Aquaculture. https://doi.org/10.1016/S0044-8486(97)00295-0

    Article  Google Scholar 

  25. Cao, G. T., Zeng, X. F., Chen, A. G., Zhou, L., Zhang, L., Xiao, Y. P., & Yang, C. M. (2013). Effects of a probiotic, Enterococcus faecium, on growth performance, intestinal morphology, immune response, and cecal microflora in broiler chickens challenged with Escherichia coli K88. Poultry Science. https://doi.org/10.3382/ps.2013-03366

    Article  PubMed  Google Scholar 

  26. Cao, L. T., Wu, J. Q., Xie, F., Hu, S. H., & Mo, Y. (2007). Efficacy of nisin in treatment of clinical mastitis in lactating dairy cows. Journal of Dairy Science. https://doi.org/10.3168/jds.2007-0153

    Article  PubMed  Google Scholar 

  27. Cao, X., Tang, L., Zeng, Z., Wang, B., Zhou, Y., Wang, Q., Zou, P., & Li, W. (2020). Effects of probiotics BaSC06 on intestinal digestion and absorption, antioxidant capacity, microbiota composition, and macrophage polarization in pigs for fattening. Frontiers Vetnary Science. https://doi.org/10.3389/fvets.2020.570593

    Article  PubMed  Google Scholar 

  28. Castex, M., Chim, L., Pham, D., Lemaire, P., Wabete, N., Nicolas, J. L., Schmidely, P., & Mariojouls, C. (2008). Probiotic P. acidilactici application in shrimp Litopenaeus stylirostris culture subject to vibriosis in New Caledonia. Aquaculture. https://doi.org/10.1016/j.aquaculture.2008.01.011

    Article  Google Scholar 

  29. Chaucheyras-Durand, F., Walker, N. D., & Bach, A. (2008). Effects of active dry yeasts on the rumen microbial ecosystem: Past, present and future. Animal Feed Science and Technology. https://doi.org/10.1016/j.anifeedsci.2007.04.019

    Article  Google Scholar 

  30. Chawla, S., Katoch, S., Sharma, K. S., & Sharma, V. K. (2013). Biological response of broiler supplemented with varying dose of direct fed microbial. Vetanary World. https://doi.org/10.5455/vetworld.2013.521-524

    Article  Google Scholar 

  31. Chen, B., Peng, M., Tong, W., Zhang, Q., & Song, Z. (2020a). The Quorum Quenching Bacterium Bacillus licheniformis T-1 protects Zebrafish against Aeromonas hydrophila infection. Probiotics Antimicrob Proteins. https://doi.org/10.1007/s12602-018-9495-7

    Article  PubMed  Google Scholar 

  32. Chen, Y. Y., Wang, Y. L., Wang, W. K., Zhang, Z. W., Si, X. M., Cao, Z. J., Li, S. L., & Yang, H. J. (2020b). Beneficial effect of Rhodopseudomonas palustris on in vitro rumen digestion and fermentation. Benef Microbes. https://doi.org/10.3920/BM2019.0044

    Article  PubMed  Google Scholar 

  33. Chiquette, J., Allison, M. J., & Rasmussen, M. A. (2008). Prevotella bryantii 25A used as a probiotic in early-lactation dairy cows: Effect on ruminal fermentation characteristics, milk production, and milk composition. Journal of Dairy Science. https://doi.org/10.3168/jds.2007-0849

    Article  PubMed  Google Scholar 

  34. Chythanya, R., Karunasagar, I., & Karunasagar, I. (2002). Inhibition of shrimp pathogenic vibrios by a marine Pseudomonas I-2 strain. Aquaculture. https://doi.org/10.1016/S0044-8486(01)00714-1

    Article  Google Scholar 

  35. Corcionivoschi, N., Drinceanu, D., Pop, I. M., Stack, D., Ştef, L., Julean, C., & Bourke, B. (2010). The Effect of Probiotics on Animal Health REVIEW, Scientific Papers: Animal Science and Biotechnologies.

  36. Da Costa, P. M., Loureiro, L., & Matos, A. J. F. (2013). Transfer of multidrug-resistant bacteria between intermingled ecological niches: The interface between humans, animals and the environment. International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph10010278

    Article  PubMed  PubMed Central  Google Scholar 

  37. Dalmin, G., Kathiresan, K., Purushothaman, A., 2001. Effect of probiotics on bacterial population and health status of shrimp in culture pond ecosystem. Indian J. Exp. Biol.

  38. Daşkiran, M., Öno, A. G., Cengiz, Ö., Ünsal, H., Türkyilmaz, S., Tatli, O., & Sevim, O. (2012). Influence of dietary probiotic inclusion on growth performance, blood parameters, and intestinal microflora of male broiler chickens exposed to posthatch holding time. J. Appl. Poult. Res., 21, 612–622. https://doi.org/10.3382/japr.2011-00512

    CAS  Article  Google Scholar 

  39. Davis, M. E., Parrott, T., Brown, D. C., de Rodas, B. Z., Johnson, Z. B., Maxwell, C. V., & Rehberger, T. (2008). Effect of a Bacillus-based direct-fed microbial feed supplement on growth performance and pen cleaning characteristics of growing-finishing pigs. Journal of Animal Science, 86, 1459–1467. https://doi.org/10.2527/jas.2007-0603

    CAS  Article  PubMed  Google Scholar 

  40. Dec, M., Puchalski, A., Urban-Chmiel, R., & Wernicki, A. (2014). Screening of Lactobacillus strains of domestic goose origin against bacterial poultry pathogens for use as probiotics. Poultry Science, 93, 2464–2472. https://doi.org/10.3382/ps.2014-04025

    CAS  Article  PubMed  Google Scholar 

  41. Deng, Y., Xu, L., Liu, S., Wang, Q., Guo, Z., Chen, C., & Feng, J. (2020a). What drives changes in the virulence and antibiotic resistance of Vibrio harveyi in the South China Sea? Journal of Fish Diseases. https://doi.org/10.1111/jfd.13197

    Article  PubMed  Google Scholar 

  42. Deng, Z., Luo, X. M., Liu, J., & Wang, H. (2020b). Quorum sensing, biofilm, and intestinal mucosal barrier: Involvement the role of probiotic. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2020.538077

    Article  PubMed  PubMed Central  Google Scholar 

  43. Desnoyers, M., Giger-Reverdin, S., Bertin, G., Duvaux-Ponter, C., & Sauvant, D. (2009). Meta-analysis of the influence of Saccharomyces cerevisiae supplementation on ruminal parameters and milk production of ruminants. Journal of Dairy Science. https://doi.org/10.3168/jds.2008-1414

    Article  PubMed  Google Scholar 

  44. Devyatkin, V., Mishurov, A., & Kolodina, E. (2021). Probiotic effect of Bacillus subtilis B-2998D, B-3057D, and Bacillus licheniformis B-2999D complex on sheep and lambs. J. Adv. Vet. Anim. Res., 8, 146–157. https://doi.org/10.5455/javar.2021.h497

    Article  PubMed  PubMed Central  Google Scholar 

  45. Du, R., Jiao, S., Dai, Y., An, J., Lv, J., Yan, X., Wang, J., & Han, B. (2018). Probiotic Bacillus amyloliquefaciens C-1 improves growth performance, stimulates GH/IGF-1, and regulates the gut microbiota of growth-retarded beef calves. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2018.02006

    Article  PubMed  PubMed Central  Google Scholar 

  46. El-Deep, M. H., Dawood, M. A. O., Assar, M. H., & Ahamad Paray, B. (2021). Aspergillus awamori positively impacts the growth performance, nutrient digestibility, antioxidative activity and immune responses of growing rabbits. Vet. Med. Sci., 7, 226–235. https://doi.org/10.1002/vms3.345

    CAS  Article  PubMed  Google Scholar 

  47. El-Sawah, A. A., Aboelhadid, S. M., El-Nahass, E. N., Helal, H. E., Korany, A. M., & El-Ashram, S. (2020). Efficacy of probiotic Enterococcus faecium in combination with diclazuril against coccidiosis in experimentally infected broilers. Journal of Applied Microbiology. https://doi.org/10.1111/jam.14691

    Article  PubMed  Google Scholar 

  48. El-Sharkawy, H., Tahoun, A., Rizk, A. M., Suzuki, T., Elmonir, W., Nassef, E., Shukry, M., Germoush, M. O., Farrag, F., Bin-Jumah, M., & Mahmoud, A. M. (2020). Evaluation of bifidobacteria and lactobacillus probiotics as alternative therapy for Salmonella typhimurium infection in broiler chickens. Animals. https://doi.org/10.3390/ani10061023

    Article  PubMed  PubMed Central  Google Scholar 

  49. Elghandour, M. M. Y., Tan, Z. L., Abu Hafsa, S. H., Adegbeye, M. J., Greiner, R., Ugbogu, E. A., Cedillo Monroy, J., & Salem, A. Z. M. (2020). Saccharomyces cerevisiae as a probiotic feed additive to non and pseudo-ruminant feeding: A review. Journal of Applied Microbiology. https://doi.org/10.1111/jam.14416

    Article  PubMed  Google Scholar 

  50. European Parliament and the Council of the European Union. (2003). Regulation (EC) No 1831/2003. Off. J. Eur. Union 4, 29–43.

  51. Fajardo, P., Pastrana, L., Méndez, J., Rodríguez, I., Fucios, C., & Guerra, N. P. (2012). Effects of feeding of two potentially probiotic preparations from lactic acid bacteria on the performance and faecal microflora of broiler chickens. The Scientific World Journal, 2012, 14–16. https://doi.org/10.1100/2012/562635

    Article  Google Scholar 

  52. FAO/WHO. (2002). Guidelines for the evaluation of probiotics in food (Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food). Food Agric. Organ. United Nations World Heal. Organ. https://doi.org/10.1111/j.1469-0691.2012.03873

  53. FAO. (2020). The State of World Fisheries and Aquaculture 2020. Sustainability in action. Nature and Resources. https://doi.org/10.4060/ca9229en

  54. FAO. (2018). GLEAM 2, 2016. Global Livestock Environmental Assessment Model. FAO, Rome,Italy. 82.

  55. FAOSTAT. (2016). Food & Agriculture Organization of the United Nations Statistics Division [WWW Document]. Food Agric. Organ. United Nations Stat. Div.

  56. Fathi, M., Abdelsalam, M., Al-Homidan, I., Ebeid, T., El-Zarei, M., & Abou-Emera, O. (2017). Effect of probiotic supplementation and genotype on growth performance, carcass traits, hematological parameters and immunity of growing rabbits under hot environmental conditions. Animal Science Journal, 88, 1644–1650. https://doi.org/10.1111/asj.12811

    CAS  Article  PubMed  Google Scholar 

  57. Fazelnia, K., Fakhraei, J., Yarahmadi, H. M., & Amini, K. (2021). Dietary supplementation of potential probiotics Bacillus subtilis, Bacillus licheniformis, and Saccharomyces cerevisiae and synbiotic improves growth performance and immune responses by modulation in intestinal system in broiler chicks challenged with Sal. Probiotics Antimicrobial Proteins. https://doi.org/10.1007/s12602-020-09737-5

  58. Forkus, B., Ritter, S., Vlysidis, M., Geldart, K., & Kaznessis, Y. N. (2017). Antimicrobial probiotics reduce Salmonella enterica in Turkey Gastrointestinal Tracts. Science and Reports, 7, 1–9. https://doi.org/10.1038/srep40695

    CAS  Article  Google Scholar 

  59. Ghareeb, K., Awad, W. A., Mohnl, M., Porta, R., Biarnés, M., Böhm, J., & Schatzmayr, G. (2012). Evaluating the efficacy of an avian-specific probiotic to reduce the colonization of Campylobacter jejuni in broiler chickens. Poultry Science. https://doi.org/10.3382/ps.2012-02168

    Article  PubMed  Google Scholar 

  60. Giannenas, I., Papadopoulos, E., Tsalie, E., Triantafillou, E., Henikl, S., Teichmann, K., & Tontis, D. (2012). Assessment of dietary supplementation with probiotics on performance, intestinal morphology and microflora of chickens infected with Eimeria tenella. Veterinary Parasitology. https://doi.org/10.1016/j.vetpar.2012.02.017

    Article  PubMed  Google Scholar 

  61. Giri, S. S., Sukumaran, V., & Oviya, M. (2013). Potential probiotic Lactobacillus plantarum VSG3 improves the growth, immunity, and disease resistance of tropical freshwater fish, Labeo rohita. Fish Shellfish Immunology. https://doi.org/10.1016/j.fsi.2012.12.008

    Article  PubMed  Google Scholar 

  62. Gomes, L. C., Brinn, R. P., Marcon, J. L., Dantas, L. A., Brandão, F. R., De Abreu, J. S., Lemos, P. E. M., McComb, D. M., & Baldisserotto, B. (2009). Benefits of using the probiotic Efinol®L during transportation of cardinal tetra, Paracheirodon axelrodi (Schultz), in the Amazon. Aquaculture Research. https://doi.org/10.1111/j.1365-2109.2008.02077.x

    Article  Google Scholar 

  63. Grace, D. (2012). The deadly gifts of livestock: Zoonoses. Agric. Dev.

  64. Gracia, M. I., José, J., & Norel, M. (2013). Effect of probiotic Ecobiol on broiler performance.

  65. Gunasundari, V., Ajith Kumar, T.T., Ghosh, S., Kumaresan, S., 2013. An ex vivo loom to evaluate the brewer’s yeast Saccharomyces cerevisiae in clownfish aquaculture with special reference to Amphiprion percula (Lacepede, 1802). Turkish J. Fish. Aquat. Sci. https://doi.org/10.4194/1303-2712-v13_3_01

  66. Haddadin, M. S. Y., Abdulrahim, S. M., Hashlamoun, E. A. R., & Robinson, R. K. (1996). The effect of Lactobacillus acidophilus on the production and chemical composition of hen’s eggs. Poultry Science. https://doi.org/10.3382/ps.0750491

    Article  PubMed  Google Scholar 

  67. Haghighi, H. R., Abdul-Careem, M. F., Dara, R. A., Chambers, J. R., & Sharif, S. (2008a). Cytokine gene expression in chicken cecal tonsils following treatment with probiotics and Salmonella infection. Veterinary Microbiology. https://doi.org/10.1016/j.vetmic.2007.06.026

    Article  PubMed  Google Scholar 

  68. Haghighi, H. R., Abdul-Careem, M. F., Dara, R. A., Chambers, J. R., & Sharif, S. (2008b). Cytokine gene expression in chicken cecal tonsils following treatment with probiotics and Salmonella infection. Veterinary Microbiology, 126, 225–233. https://doi.org/10.1016/j.vetmic.2007.06.026

    CAS  Article  PubMed  Google Scholar 

  69. Hai, N. V. (2015). The use of probiotics in aquaculture. Journal of Applied Microbiology, 119, 917–935. https://doi.org/10.1111/jam.12886

    CAS  Article  PubMed  Google Scholar 

  70. Hai, N. V., Buller, N., & Fotedar, R. (2009a). Effects of probiotics (pseudomonas synxantha and pseudomonas aeruginosa) on the growth, survival and immune parameters of juvenile western king prawns (penaeus latisulcatus kishinouye, 1896). Aquaculture Research. https://doi.org/10.1111/j.1365-2109.2008.02135.x

    Article  Google Scholar 

  71. Han, T., Zhang, Q., Liu, N., Wang, J., Li, Y., Huang, X., Liu, J., Wang, J., Qu, Z., & Qi, K. (2020). Changes in antibiotic resistance of Escherichia coli during the broiler feeding cycle. Poultry Science. https://doi.org/10.1016/j.psj.2020.06.068

    Article  PubMed  PubMed Central  Google Scholar 

  72. Hardy, H., Harris, J., Lyon, E., Beal, J., & Foey, A. D. (2013). Probiotics, prebiotics and immunomodulation of gut mucosal defences: Homeostasis and immunopathology. Nutrients. https://doi.org/10.3390/nu5061869

    Article  PubMed  PubMed Central  Google Scholar 

  73. Hashemzadeh, F., Rahimi, S., Amir, M., Torshizi, K., Akbar, A., Torshizi, M.A.K., Akbar, A., 2013. Effects of Probiotics and Antibiotic Supplementation on Serum Biochemistry and Intestinal Microflora in Broiler Chicks. Int. J. Agric. Crop Sci.

  74. Hassoun-Kheir, N., Stabholz, Y., Kreft, J. U., de la Cruz, R., Romalde, J. L., Nesme, J., Sørensen, S. J., Smets, B. F., Graham, D., & Paul, M. (2020). Comparison of antibiotic-resistant bacteria and antibiotic resistance genes abundance in hospital and community wastewater: A systematic review. Science of the Total Environment. https://doi.org/10.1016/j.scitotenv.2020.140804

    Article  Google Scholar 

  75. Hong, H. A., Le, H. D., & Cutting, S. M. (2005). The use of bacterial spore formers as probiotics. FEMS Microbiology Reviews. https://doi.org/10.1016/j.femsre.2004.12.001

    Article  PubMed  Google Scholar 

  76. Huang, Z., Mu, C., Chen, Y., Zhu, Z., Chen, C., Lan, L., Xu, Q., Zhao, W., & Chen, G. (2015). Effects of dietary probiotic supplementation on LXRα and CYP7α1 gene expression, liver enzyme activities and fat metabolism in ducks. British Poultry Science, 56, 218–224. https://doi.org/10.1080/00071668.2014.1000821

    CAS  Article  PubMed  Google Scholar 

  77. Huddy, R. J., & Coyne, V. E. (2015). Characterisation of the role of an alkaline protease from Vibrio midae SY9 in enhancing the growth rate of cultured abalone fed a probiotic-supplemented feed. Aquaculture. https://doi.org/10.1016/j.aquaculture.2015.05.048

    Article  Google Scholar 

  78. Hughes, D. T., & Sperandio, V. (2008). Inter-kingdom signalling: Communication between bacteria and their hosts. Nature Reviews Microbiology. https://doi.org/10.1038/nrmicro1836

    Article  PubMed  PubMed Central  Google Scholar 

  79. Hung, A.T., Lin, S.Y., Yang, T.Y., Chou, C.K., Liu, H.C., Lu, J.J., Wang, B., Chen, S.Y., Lien, T.F., 2012. Effects of Bacillus coagulans ATCC 7050 on growth performance, intestinal morphology, and microflora composition in broiler chickens. Anim. Prod. Sci. https://doi.org/10.1071/AN11332

  80. Jayaraman, S., Thangavel, G., Kurian, H., Mani, R., Mukkalil, R., & Chirakkal, H. (2013). Bacillus subtilis PB6 improves intestinal health of broiler chickens challenged with Clostridium perfringens-induced necrotic enteritis. Poultry Science. https://doi.org/10.3382/ps.2012-02528

    Article  PubMed  Google Scholar 

  81. Jin, L. Z., Ho, Y. W., Abdullah, N., Ali, M. A., & Jalaludin, S. (1996). Antagonistic effects of intestinal Lactobacillus isolates on pathogens of chicken. Letters in Applied Microbiology. https://doi.org/10.1111/j.1472-765X.1996.tb00032.x

    Article  PubMed  Google Scholar 

  82. Jing, W., Liu, Q., & Wang, W. (2020). Bifidobacterium bifidum TMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double-blind control trial. Journal of Food Biochemistry. https://doi.org/10.1111/jfbc.13489

    Article  PubMed  Google Scholar 

  83. Jouany, J. P., Mathieu, F., Senaud, J., Bohatier, J., Bertin, G., & Mercier, M. (1998). Effect of Saccharomyces cerevisiae and Aspergillus oryzae on the digestion of nitrogen in the rumen of defaunated and refaunated sheep. Animal Feed Science and Technology. https://doi.org/10.1016/S0377-8401(98)00194-1

    Article  Google Scholar 

  84. Kalavathy, R., Abdullah, N., Jalaludin, S., & Ho, Y. W. (2003). Effects of Lactobacillus cultures on growth performance, abdominal fat deposition, serum lipids and weight of organs of broiler chickens. British Poultry Science. https://doi.org/10.1080/0007166031000085445

    Article  PubMed  Google Scholar 

  85. Kantas, D., Papatsiros, V. G., Tassis, P. D., Giavasis, I., Bouki, P., & Tzika, E. D. (2015). A feed additive containing Bacillus toyonensis (Toyocerin®) protects against enteric pathogens in postweaning piglets. Journal of Applied Microbiology. https://doi.org/10.1111/jam.12729

    Article  PubMed  Google Scholar 

  86. Kapsenberg, M. L. (2003). Dendritic-cell control of pathogen-driven T-cell polarization. Nature Reviews Immunology. https://doi.org/10.1038/nri1246

    Article  PubMed  Google Scholar 

  87. Kawai, Y., Ishii, Y., Arakawa, K., Uemura, K., Saitoh, B., Nishimura, J., Kitazawa, H., Yamazaki, Y., Tateno, Y., Itoh, T., & Saito, T. (2004). Structural and functional differences in two cyclic bacteriocins with the same sequences produced by lactobacilli. Applied and Environment Microbiology. https://doi.org/10.1128/AEM.70.5.2906-2911.2004

    Article  Google Scholar 

  88. Kewcharoen, W., Srisapoome, P., 2019. Probiotic effects of Bacillus spp. from Pacific white shrimp (Litopenaeus vannamei) on water quality and shrimp growth, immune responses, and resistance to Vibrio parahaemolyticus (AHPND strains). Fish Shellfish Immunol. https://doi.org/10.1016/j.fsi.2019.09.013

  89. Khaksarzareha, V., Golian, A., Kermanshahi, H., 2012. Immune response and ileal microflora in broilers fed wheat-based diet with or without enzyme Endofeed W and supplementation of thyme essential oil or probiotic PrimaLac®. African J. Biotechnol. https://doi.org/10.5897/AJB12.1237

  90. Khalid, A. H., Ullah, K. S., Naveed, S., Latif, F., Pasha, T. N., Hussain, I., & Qaisrani, S. N. (2021). Effects of spray dried yeast (Saccharomyces cerevisiae) on growth performance and carcass characteristics, gut health, cecal microbiota profile and apparent ileal digestibility of protein, amino acids and energy in broilers. Tropical Animal Health and Production. https://doi.org/10.1007/s11250-021-02684-5

    Article  PubMed  Google Scholar 

  91. Khattab, A. A. A., El Basuini, M. F. M., El-Ratel, I. T., & Fouda, S. F. (2021). Dietary probiotics as a strategy for improving growth performance, intestinal efficacy, immunity, and antioxidant capacity of white Pekin ducks fed with different levels of CP. Poultry Science, 100, 100898. https://doi.org/10.1016/j.psj.2020.11.067

    CAS  Article  PubMed  Google Scholar 

  92. Kim, S. R., Nonaka, L., & Suzuki, S. (2004). Occurrence of tetracycline resistance genes tet(M) and tet(S) in bacteria from marine aquaculture sites. FEMS Microbiology Letters. https://doi.org/10.1016/j.femsle.2004.06.026

    Article  PubMed  Google Scholar 

  93. Kong, Y., Gao, C., Du, X., Zhao, J., Li, M., Shan, X., & Wang, G. (2020). Effects of single or conjoint administration of lactic acid bacteria as potential probiotics on growth, immune response and disease resistance of snakehead fish (Channa argus). Fish & Shellfish Immunology. https://doi.org/10.1016/j.fsi.2020.05.003

    Article  Google Scholar 

  94. Krehbiel, C., Rust, S., Zhang, G., & Gilliland, S. (2003). Bacterial direct-fed microbials in ruminant diets: Performance response and mode of action. Journal of Animal Science. https://doi.org/10.2527/2003.8114_suppl_2E120x

    Article  PubMed  Google Scholar 

  95. Kritas, S. K., Govaris, A., Christodoulopoulos, G., & Burriel, A. R. (2006). Effect of Bacillus licheniformis and Bacillus subtilis supplementation of ewe’s feed on sheep milk production and young lamb mortality. J. Vet. Med. Ser. A Physiol. Pathol. Clin. Med., 53, 170–173. https://doi.org/10.1111/j.1439-0442.2006.00815.x

    CAS  Article  Google Scholar 

  96. Kuebutornye, F. K. A., Abarike, E. D., Lu, Y., Hlordzi, V., Sakyi, M. E., Afriyie, G., Wang, Z., Li, Y., & Xie, C. X. (2020). Mechanisms and the role of probiotic Bacillus in mitigating fish pathogens in aquaculture. Fish Physiology and Biochemistry. https://doi.org/10.1007/s10695-019-00754-y

    Article  PubMed  Google Scholar 

  97. Kurtoglu, V., Kurtoglu, F., Seker, E., Coskun, B., Balevi, T., & Polat, E. S. (2004). Effect of probiotic supplementation on laying hen diets on yield performance and serum and egg yolk cholesterol. Food Additives & Contaminants. https://doi.org/10.1080/02652030310001639530

    Article  Google Scholar 

  98. Lajis, A.F.B., 2020. Biomanufacturing process for the production of bacteriocins from Bacillaceae family. Bioresour. Bioprocess. https://doi.org/10.1186/s40643-020-0295-z

  99. Landy, N., Kavyani, A., 2013. a Multi-Strain Probiotic on Performance, Immune Responses and Cecal Microflora Composition in Broiler Chickens Reared Under Cyclic Heat Stress Condition. Iran. J. Appl. Anim. Sci.

  100. Langenkamp, A., Messi, M., Lanzavecchia, A., & Sallusto, F. (2000). Kinetics of dendritic cell activation: Impact on priming of TH1, TH2 and nonpolarized T cells. Nature Immunology. https://doi.org/10.1038/79758

    Article  PubMed  Google Scholar 

  101. Lara-Flores, M., Olvera-Novoa, M. A., Guzmán-Méndez, B. E., & López-Madrid, W. (2003). Use of the bacteria Streptococcus faecium and Lactobacillus acidophilus, and the yeast Saccharomyces cerevisiae as growth promoters in Nile tilapia (Oreochromis niloticus). Aquaculture. https://doi.org/10.1016/S0044-8486(02)00277-6

    Article  Google Scholar 

  102. Lei, X., Piao, X., Ru, Y., Zhang, Hongyu, Péron, A., Zhang, Huifang, 2015. Effect of Bacillus amyloliquefaciens-based direct-fed microbial on performance, nutrient utilization, intestinal morphology and cecal microflora in broiler chickens. Asian-Australasian J. Anim. Sci. https://doi.org/10.5713/ajas.14.0330

  103. Leonel Ochoa-Solano, J., & Olmos-Soto, J. (2006). The functional property of Bacillus for shrimp feeds. Food Microbiology. https://doi.org/10.1016/j.fm.2005.10.004

    Article  PubMed  Google Scholar 

  104. Leyva-Madrigal, K. Y., Luna-González, A., Escobedo-Bonilla, C. M., Fierro-Coronado, J. A., & Maldonado-Mendoza, I. E. (2011). Screening for potential probiotic bacteria to reduce prevalence of WSSV and IHHNV in whiteleg shrimp (Litopenaeus vannamei) under experimental conditions. Aquaculture. https://doi.org/10.1016/j.aquaculture.2011.09.033

    Article  Google Scholar 

  105. Li, P., Gatlin, D.M., 2005. Evaluation of the prebiotic GroBiotic®-A and brewers yeast as dietary supplements for sub-adult hybrid striped bass (Morone chrysops x M. saxatilis) challenged in situ with Mycobacterium marinum, in: Aquaculture. https://doi.org/10.1016/j.aquaculture.2005.03.005

  106. Li, P., Gatlin, D.M., 2004. Dietary brewers yeast and the prebiotic GrobioticTM AE influence growth performance, immune responses and resistance of hybrid striped bass (Morone chrysops x M. saxatilis) to Streptococcus iniae infection. Aquaculture. https://doi.org/10.1016/j.aquaculture.2003.08.021

  107. Li, X. Y., Duan, Y. L., Yang, X., & Yang, X. J. (2020). Effects of Bacillus subtilis and antibiotic growth promoters on the growth performance, intestinal function and gut microbiota of pullets from 0 to 6 weeks. Animal. https://doi.org/10.1017/S1751731120000191

    Article  PubMed  PubMed Central  Google Scholar 

  108. Liao, S. F., & Nyachoti, M. (2017). Using probiotics to improve swine gut health and nutrient utilization. Anim: Nutr. https://doi.org/10.1016/j.aninu.2017.06.007

    Book  Google Scholar 

  109. Lilly, D. M., & Stillwell, R. H. (1965). Probiotics: Growth-promoting factors produced by microorganisms. Science (80). https://doi.org/10.1126/science.147.3659.747

  110. Liu, L., Zeng, D., Yang, M., Wen, B., Lai, J., Zhou, Y., Sun, H., Xiong, L., Wang, J., Lin, Y., Pan, K., Jing, B., Wang, P., & Ni, X. (2019). Probiotic Clostridium butyricum improves the growth performance, immune function, and gut microbiota of weaning rex rabbits. Probiotics Antimicrob. Proteins, 11, 1278–1292. https://doi.org/10.1007/s12602-018-9476-x

    CAS  Article  PubMed  Google Scholar 

  111. Luongo, D., Miyamoto, J., Bergamo, P., Nazzaro, F., Baruzzi, F., Sashihara, T., Tanabe, S., & Rossi, M. (2013). Differential modulation of innate immunity in vitro by probiotic strains of Lactobacillus gasseri. BMC Microbiology. https://doi.org/10.1186/1471-2180-13-298

    Article  PubMed  PubMed Central  Google Scholar 

  112. Ma, Z. Z., Cheng, Y. Y., Wang, S. Q., Ge, J. Z., Shi, H. P., & Kou, J. C. (2020). Positive effects of dietary supplementation of three probiotics on milk yield, milk composition and intestinal flora in Sannan dairy goats varied in kind of probiotics. Journal of Animal Physiology and Animal Nutrition (berlin). https://doi.org/10.1111/jpn.13226

    Article  Google Scholar 

  113. Maas, R. M., Verdegem, M. C. J., Debnath, S., Marchal, L., & Schrama, J. W. (2021). Effect of enzymes (phytase and xylanase), probiotics (B. amyloliquefaciens) and their combination on growth performance and nutrient utilisation in Nile tilapia. Aquaculture. https://doi.org/10.1016/j.aquaculture.2020.736226

    Article  Google Scholar 

  114. Maldonado Galdeano, C., Cazorla, S. I., Lemme Dumit, J. M., Vélez, E., & Perdigón, G. (2019). Beneficial effects of probiotic consumption on the immune system. Annals of Nutrition & Metabolism, 74, 115–124. https://doi.org/10.1159/000496426

    CAS  Article  Google Scholar 

  115. Marques, A., Thanh, T. H., Sorgeloos, P., & Bossier, P. (2006). Use of microalgae and bacteria to enhance protection of gnotobiotic Artemia against different pathogens. Aquaculture. https://doi.org/10.1016/j.aquaculture.2006.04.021

    Article  Google Scholar 

  116. Marshall, B. M., & Levy, S. B. (2011). Food animals and antimicrobials: Impacts on human health. Clinical Microbiology Reviews. https://doi.org/10.1128/CMR.00002-11

    Article  PubMed  PubMed Central  Google Scholar 

  117. Mathieu, F., Jouany, J. P., Sénaud, J., Bohatier, J., Bertin, G., & Mercier, M. (1996). The effect of Saccharomyces cerevisiae and Aspergillus oryzae on fermentations in the rumen of faunated and defaunated sheep; protozoal and probiotic interactions. Reproduction, Nutrition, Development. https://doi.org/10.1051/rnd:19960305

    Article  PubMed  Google Scholar 

  118. Mellman, I., & Steinman, R. M. (2001). Dendritic cells: Specialized and regulated antigen processing machines. Cell. https://doi.org/10.1016/S0092-8674(01)00449-4

    Article  PubMed  Google Scholar 

  119. Midhun, S. J., Neethu, S., Arun, D., Vysakh, A., Divya, L., Radhakrishnan, E. K., & Jyothis, M. (2019). Dietary supplementation of Bacillus licheniformis HGA8B improves growth parameters, enzymatic profile and gene expression of Oreochromis niloticus. Aquaculture. https://doi.org/10.1016/j.aquaculture.2019.02.064

    Article  Google Scholar 

  120. Miller, M. B., & Bassler, B. L. (2001). Quorum sensing in bacteria. Annual Review of Microbiology. https://doi.org/10.1146/annurev.micro.55.1.165

    Article  PubMed  Google Scholar 

  121. Mo, W. Y., Choi, W. M., Man, K. Y., & Wong, M. H. (2020). Food waste-based pellets for feeding grass carp (Ctenopharyngodon idellus): Adding baker’s yeast and enzymes to enhance growth and immunity. Science of the Total Environment. https://doi.org/10.1016/j.scitotenv.2019.134954

    Article  Google Scholar 

  122. Mohammed, A. A., Zaki, R. S., Negm, E. A., Mahmoud, M. A., & Cheng, H. W. (2021). Effects of dietary supplementation of a probiotic (Bacillus subtilis) on bone mass and meat quality of broiler chickens. Poultry Science. https://doi.org/10.1016/j.psj.2020.11.073

    Article  PubMed  PubMed Central  Google Scholar 

  123. Mohanty S. K.,Tripathi, S. D., & Swai, S. N. (1996). Rearing of catla (Catla catla Ham.) spawn on formulated diets. J. AQUACULT. TROP. .

  124. Mookiah, S., Sieo, C. C., Ramasamy, K., Abdullah, N., & Ho, Y. W. (2014). Effects of dietary prebiotics, probiotic and synbiotics on performance, caecal bacterial populations and caecal fermentation concentrations of broiler chickens. Journal of the Science of Food and Agriculture. https://doi.org/10.1002/jsfa.6365

    Article  PubMed  Google Scholar 

  125. Moriarty, D. J. W. (1998). Control of luminous Vibrio species in penaeid aquaculture ponds. Aquaculture. https://doi.org/10.1016/S0044-8486(98)00199-9

    Article  Google Scholar 

  126. Morishita, T. Y., Aye, P. P., Harr, B. S., Cobb, C. W., & Clifford, J. R. (1997). Evaluation of an avian-specific probiotic to reduce the colonization and shedding of Campylobacter jejuni in Broilers. Avian Diseases. https://doi.org/10.2307/1592338

    Article  PubMed  Google Scholar 

  127. Mountzouris, K. C., Balaskas, C., Xanthakos, I., Tzivinikou, A., & Fegeros, K. (2009). Effects of a multi-species probiotic on biomarkers of competitive exclusion efficacy in broilers challenged with Salmonella enteritidis. British Poultry Science. https://doi.org/10.1080/00071660903110935

    Article  PubMed  Google Scholar 

  128. Mountzouris, K. C., Tsitrsikos, P., Palamidi, I., Arvaniti, A., Mohnl, M., Schatzmayr, G., & Fegeros, K. (2010). Effects of probiotic inclusion levels in broiler nutrition on growth performance, nutrient digestibility, plasma immunoglobulins, and cecal microflora composition. Poultry Science. https://doi.org/10.3382/ps.2009-00308

    Article  PubMed  Google Scholar 

  129. Muya, M. C., Nherera, F. V., Miller, K. A., Aperce, C. C., Moshidi, P. M., & Erasmus, L. J. (2015). Effect of Megasphaera elsdenii NCIMB 41125 dosing on rumen development, volatile fatty acid production and blood β-hydroxybutyrate in neonatal dairy calves. Journal of Animal Physiology and Animal Nutrition (berlin). https://doi.org/10.1111/jpn.12306

    Article  Google Scholar 

  130. Naas, K. E., Næss, T., & Harboe, T. (1992). Enhanced first feeding of halibut larvae (Hippoglossus hippoglossus L.) in green water. Aquaculture. https://doi.org/10.1016/0044-8486(92)90126-6

    Article  Google Scholar 

  131. Nocek, J. E., & Kautz, W. P. (2006). Direct-fed microbial supplementation on ruminal digestion, health, and performance of pre- and postpartum dairy cattle. Journal of Dairy Science. https://doi.org/10.3168/jds.S0022-0302(06)72090-2

    Article  PubMed  Google Scholar 

  132. Noor, Z., Noor, M., Khan, I., & Khan, S. A. (2020). Evaluating the lucrative role of probiotics in the aquaculture using microscopic and biochemical techniques. Microscopy Research and Technique, 83, 310–317. https://doi.org/10.1002/jemt.23416

    CAS  Article  PubMed  Google Scholar 

  133. Ohya, T., Marubashi, T., & Ito, H. (2000). Significance of fecal volatile fatty acids in shedding of Escherichia coli O157 from calves: experimental infection and preliminary use of a probiotic product. Journal of Veterinary Medical Science, 62, 1151–1155. https://doi.org/10.1292/jvms.62.1151

    CAS  Article  Google Scholar 

  134. Olmos, J., Acosta, M., Mendoza, G., & Pitones, V. (2020). Bacillus subtilis, an ideal probiotic bacterium to shrimp and fish aquaculture that increase feed digestibility, prevent microbial diseases, and avoid water pollution. Archives of Microbiology, 202, 427–435. https://doi.org/10.1007/s00203-019-01757-2

    CAS  Article  PubMed  Google Scholar 

  135. Panda, A. K., Reddy, M. R., Rama Rao, S. V., & Praharaj, N. K. (2003). Production performance, serum/yolk cholesterol and immune competence of White Leghorn layers as influenced by dietary supplementation with probiotic. Tropical Animal Health and Production. https://doi.org/10.1023/A:1022036023325

    Article  PubMed  Google Scholar 

  136. Park, S. C., Shimamura, I., Fukunaga, M., Mori, K. I., & Nakai, T. (2000). Isolation of bacteriophages specific to a fish pathogen, Pseudomonas plecoglossicida, as a candidate for disease control. Applied and Environment Microbiology. https://doi.org/10.1128/AEM.66.4.1416-1422.2000

    Article  Google Scholar 

  137. Park, Y. H., Hamidon, F., Rajangan, C., Soh, K. P., Gan, C. Y., Lim, T. S., Abdullah, W. N. W., & Liong, M. T. (2016). Application of probiotics for the production of safe and high-quality poultry meat. Korean Journal for Food Science of Animal Resources, 36, 567–576. https://doi.org/10.5851/kosfa.2016.36.5.567

    Article  PubMed  PubMed Central  Google Scholar 

  138. Pedroso, A. A., Hurley-Bacon, A. L., Zedek, A. S., Kwan, T. W., Jordan, A. P. O., Avellaneda, G., Hofacre, C. L., Oakley, B. B., Collett, S. R., Maurer, J. J., & Lee, M. D. (2013). Can probiotics improve the environmental microbiome and resistome of commercial poultry production? International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph10104534

    Article  PubMed  PubMed Central  Google Scholar 

  139. Pérez-Cano, F. J., Dong, H., & Yaqoob, P. (2010). In vitro immunomodulatory activity of Lactobacillus fermentum CECT5716 and Lactobacillus salivarius CECT5713: Two probiotic strains isolated from human breast milk. Immunobiology. https://doi.org/10.1016/j.imbio.2010.01.004

    Article  PubMed  Google Scholar 

  140. Pietras, M. (2001). The effect of probiotics on selected blood and meat parameters of broiler chickens. J Anim Feed Sci. https://doi.org/10.22358/jafs/70112/2001

    Article  Google Scholar 

  141. Plaza-Diaz, J., Ruiz-Ojeda, F. J., Gil-Campos, M., & Gil, A. (2019). Mechanisms of action of probiotics. Advances in Nutrition, 10, S49–S66. https://doi.org/10.1093/advances/nmy063

    Article  PubMed  PubMed Central  Google Scholar 

  142. Punetha, M., Roy, A. K., Ajithakumar, H. M., Para, I. A., Gupta, D., Singh, M., & Bharati, J. (2018). Immunomodulatory effects of probiotics and prilled fat supplementation on immune genes expression and lymphocyte proliferation of transition stage Karan Fries cows. Vet World. https://doi.org/10.14202/vetworld.2018.209-214

    Article  PubMed  PubMed Central  Google Scholar 

  143. Rahman, M. S., Mustari, A., Salauddin, M., & Rahman, M. M. (2013). Effects of probiotics and enzymes on growth performance and haematobiochemical parameters in broilers. J. Bangladesh Agril. Univ, 11, 111–118.

    Article  Google Scholar 

  144. Rajput, D. S., Zeng, D., Khalique, A., Rajput, S. S., Wang, H., Zhao, Y., Sun, N., & Ni, X. (2020). Pretreatment with probiotics ameliorate gut health and necrotic enteritis in broiler chickens, a substitute to antibiotics. AMB Express. https://doi.org/10.1186/s13568-020-01153-w

    Article  PubMed  PubMed Central  Google Scholar 

  145. Ramesh, D., Vinothkanna, A., Rai, A. K., & Vignesh, V. S. (2015). Isolation of potential probiotic spp and assessment of their subcellular components to induce immune responses in Labeo rohita against Aeromonas hydrophila. Fish & Shellfish Immunology. https://doi.org/10.1016/j.fsi.2015.04.018

    Article  Google Scholar 

  146. Redweik, G. A. J., Stromberg, Z. R., Van Goor, A., & Mellata, M. (2020). Protection against avian pathogenic Escherichia coli and Salmonella Kentucky exhibited in chickens given both probiotics and live Salmonella vaccine. Poultry Science, 99, 752–762. https://doi.org/10.1016/j.psj.2019.10.038

    Article  PubMed  Google Scholar 

  147. Reitan, K. I., Rainuzzo, J. R., Øie, G., & Olsen, Y. (1997). A review of the nutritional effects of algae in marine fish larvae. Aquaculture. https://doi.org/10.1016/S0044-8486(97)00118-X

    Article  Google Scholar 

  148. Rizzo, A., Fiorentino, M., Buommino, E., Donnarumma, G., Losacco, A., & Bevilacqua, N. (2015). Lactobacillus crispatus mediates anti-inflammatory cytokine interleukin-10 induction in response to Chlamydia trachomatis infection in vitro. International Journal of Medical Microbiology. https://doi.org/10.1016/j.ijmm.2015.07.005

    Article  PubMed  Google Scholar 

  149. Russo, P., Arena, M. P., Fiocco, D., Capozzi, V., Drider, D., & Spano, G. (2017). Lactobacillus plantarum with broad antifungal activity: A promising approach to increase safety and shelf-life of cereal-based products. International Journal of Food Microbiology. https://doi.org/10.1016/j.ijfoodmicro.2016.04.027

    Article  PubMed  Google Scholar 

  150. Sato, K., Takahashi, K., Tohno, M., Miura, Y., Kamada, T., Ikegami, S., & Kitazawa, H. (2009). Immunomodulation in gut-associated lymphoid tissue of neonatal chicks by immunobiotic diets. Poultry Science. https://doi.org/10.3382/ps.2009-00291

    Article  PubMed  Google Scholar 

  151. Seo, J. K., Kim, S. W., Kim, M. H., Upadhaya, S. D., Kam, D. K., & Ha, J. K. (2010). Direct-fed microbials for ruminant animals. Asian-Australasian Journal of Animal Sciences: Asian-Australasian Association of Animal Production Societies. https://doi.org/10.5713/ajas.2010.r.08

    Article  Google Scholar 

  152. Sharma, A. N., Kumar, S., & Tyagi, A. K. (2018). Effects of mannan-oligosaccharides and Lactobacillus acidophilus supplementation on growth performance, nutrient utilization and faecal characteristics in Murrah buffalo calves. Journal of Animal Physiology and Animal Nutrition (berlin), 102, 679–689. https://doi.org/10.1111/jpn.12878

    CAS  Article  Google Scholar 

  153. Shim, Y. H., Ingale, S. L., Kim, J. S., Kim, K. H., Seo, D. K., Lee, S. C., Chae, B. J., & Kwon, I. K. (2012). A multi-microbe probiotic formulation processed at low and high drying temperatures: Effects on growth performance, nutrient retention and caecal microbiology of broilers. British Poultry Science. https://doi.org/10.1080/00071668.2012.690508

    Article  PubMed  Google Scholar 

  154. Signorini, M. L., Soto, L. P., Zbrun, M. V., Sequeira, G. J., Rosmini, M. R., & Frizzo, L. S. (2012). Impact of probiotic administration on the health and fecal microbiota of young calves: A meta-analysis of randomized controlled trials of lactic acid bacteria. Research in Veterinary Science. https://doi.org/10.1016/j.rvsc.2011.05.001

    Article  PubMed  Google Scholar 

  155. Skjermo, J., & Vadstein, O. (1999). Techniques for microbial control in the intensive rearing of marine larvae. Aquaculture. https://doi.org/10.1016/S0044-8486(99)00096-4

    Article  Google Scholar 

  156. Sobczak, A., & Kozłowski, K. (2015). The effect of a probiotic preparation containing Bacillus subtilis ATCC PTA-6737 on egg production and physiological parameters of laying hens. Ann. Anim. Sci., 15, 711–723. https://doi.org/10.1515/aoas-2015-0040

    CAS  Article  Google Scholar 

  157. Soltani, M., Ghosh, K., Hoseinifar, S. H., Kumar, V., Lymbery, A. J., Roy, S., & Ringø, E. (2019). Genus bacillus, promising probiotics in aquaculture: Aquatic animal origin, bio-active components, bioremediation and efficacy in fish and shellfish. Rev Fish Sci Aquac. https://doi.org/10.1080/23308249.2019.1597010

    Article  Google Scholar 

  158. Sun, K., Xie, C., Xu, D., Yang, X., Tang, J., & Ji, X. (2013). Lactobacillus isolates from healthy volunteers exert immunomodulatory effects on activated peripheral blood mononuclear cells. Journal of Biomedical Research. https://doi.org/10.7555/JBR.27.20120074

    Article  PubMed  PubMed Central  Google Scholar 

  159. Supamattaya, K., Kiriratnikom, S., Boonyaratpalin, M., & Borowitzka, L. (2005). Effect of a Dunaliella extract on growth performance, health condition, immune response and disease resistance in black tiger shrimp (Penaeus monodon). Aquaculture. https://doi.org/10.1016/j.aquaculture.2005.04.014

    Article  Google Scholar 

  160. Surendran Nair, M., Amalaradjou, M. A., & Venkitanarayanan, K. (2017). Antivirulence properties of probiotics in combating microbial pathogenesis. Advances in Applied Microbiology. https://doi.org/10.1016/bs.aambs.2016.12.001

    Article  PubMed  Google Scholar 

  161. Taherpour, K., Moravej, H., Shivazad, M., Adibmoradi, M., & Yakhchali, B. (2009). Effects of dietary probiotic, prebiotic and butyric acid glycerides on performance and serum composition in broiler chickens. African J Biotechnol. https://doi.org/10.4314/ajb.v8i10.60590

    Article  Google Scholar 

  162. Tanwar, J., Das, S., Fatima, Z., & Hameed, S. (2014). Multidrug resistance: An emerging crisis. Interdiscip Perspect Infect Dis. https://doi.org/10.1155/2014/541340

    Article  PubMed  PubMed Central  Google Scholar 

  163. Taoka, Y., Maeda, H., Jo, J. Y., Jeon, M. J., Bai, S. C., Lee, W. J., Yuge, K., & Koshio, S. (2006). Growth, stress tolerance and non-specific immune response of Japanese flounder Paralichthys olivaceus to probiotics in a closed recirculating system. Fisheries Science. https://doi.org/10.1111/j.1444-2906.2006.01152.x

    Article  Google Scholar 

  164. Taras, D., Vahjen, W., Macha, M., & Simon, O. (2005). Response of performance characteristics and fecal consistency to long-lasting dietary supplementation with the probiotic strain Bacillus cereus var. toyoi to sows and piglets. Archives of Animal Nutrition. https://doi.org/10.1080/17450390500353168

    Article  PubMed  Google Scholar 

  165. Tellez, G., Pixley, C., Wolfenden, R. E., Layton, S. L., & Hargis, B. M. (2012). Probiotics/direct fed microbials for Salmonella control in poultry. Food Research International. https://doi.org/10.1016/j.foodres.2011.03.047

    Article  Google Scholar 

  166. Terada, T., Nii, T., Isobe, N., & Yoshimura, Y. (2020). Effects of probiotics Lactobacillus reuteri and Clostridium butyricum on the expression of toll-like receptors, pro- and anti-inflammatory cytokines, and antimicrobial peptides in broiler chick intestine. The Journal of Poultry Science. https://doi.org/10.2141/jpsa.0190098

    Article  PubMed  PubMed Central  Google Scholar 

  167. United Nations Department of Economic and Social Affairs Population Division. (2017). World Population Prospects: The 2017 Revision. World Popul. Prospect.

  168. Upadhaya, S. D., Rudeaux, F., & Kim, I. H. (2019). Efficacy of dietary Bacillus subtilis and Bacillus licheniformis supplementation continuously in pullet and lay period on egg production, excreta microflora, and egg quality of Hyline-Brown birds. Poultry Science. https://doi.org/10.3382/ps/pez184

    Article  PubMed  Google Scholar 

  169. Uyeno, Y., Shigemori, S., & Shimosato, T. (2015). Effect of probiotics/prebiotics on cattle health and productivity. Microbes and Environments. https://doi.org/10.1264/jsme2.ME14176

    Article  PubMed  PubMed Central  Google Scholar 

  170. Van Doan, H., Hoseinifar, S. H., Tapingkae, W., Seel-audom, M., Jaturasitha, S., Dawood, M. A. O., Wongmaneeprateep, S., Thu, T. T. N., & Esteban, M. Á. (2020). Boosted growth performance, mucosal and serum immunity, and disease resistance Nile Tilapia (Oreochromis niloticus) Fingerlings Using Corncob-Derived Xylooligosaccharide and Lactobacillus plantarum CR1T5. Probiotics Antimicrobial Proteins. https://doi.org/10.1007/s12602-019-09554-5

    Article  PubMed  Google Scholar 

  171. van Hai, N., Buller, N., & Fotedar, R. (2010). Effect of customized probiotics on the physiological and immunological responses of juvenile western king prawns (Penaeus latisulcatus Kishinouye, 1896) challenged with Vibrio harveyi. Journal of Applied Aquaculture. https://doi.org/10.1080/10454438.2010.527580

    Article  Google Scholar 

  172. Van Hai, N., Buller, N., & Fotedar, R. (2009b). The use of customised probiotics in the cultivation of western king prawns (Penaeus latisulcatus Kishinouye, 1896). Fish & Shellfish Immunology. https://doi.org/10.1016/j.fsi.2009.05.004

    Article  Google Scholar 

  173. van Zyl, W. F., Deane, S. M., & Dicks, L. M. T. (2020). Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria. Gut Microbes. https://doi.org/10.1080/19490976.2020.1831339

    Article  PubMed  PubMed Central  Google Scholar 

  174. Waiyamitra, P., Zoral, M. A., Saengtienchai, A., Luengnaruemitchai, A., Decamp, O., Gorgoglione, B., & Surachetpong, W. (2020). Probiotics modulate tilapia resistance and immune response against tilapia lake virus infection. Pathogens, 9, 1–15. https://doi.org/10.3390/pathogens9110919

    CAS  Article  Google Scholar 

  175. Wang, C., Chang, T., Yang, H., & Cui, M. (2015). Antibacterial mechanism of lactic acid on physiological and morphological properties of Salmonella enteritidis, Escherichia coli and Listeria monocytogenes. Food Control. https://doi.org/10.1016/j.foodcont.2014.06.034

    Article  Google Scholar 

  176. Wang, L., Li, L., Lv, Y., Chen, Q., Feng, J., & Zhao, X. (2018). Lactobacillus plantarum Restores Intestinal Permeability Disrupted by Salmonella Infection in Newly-hatched Chicks. Science Reports. https://doi.org/10.1038/s41598-018-20752-z

    Article  Google Scholar 

  177. Wang, R., Guo, Z., Tang, Y., Kuang, J., Duan, Y., Lin, H., Jiang, S., Shu, H., & Huang, J. (2020). Effects on development and microbial community of shrimp Litopenaeus vannamei larvae with probiotics treatment. AMB Express. https://doi.org/10.1186/s13568-020-01041-3

    Article  PubMed  PubMed Central  Google Scholar 

  178. Wang, Y., & He, Z. (2009). Effect of probiotics on alkaline phosphatase activity and nutrient level in sediment of shrimp, Penaeus vannamei, ponds. Aquaculture. https://doi.org/10.1016/j.aquaculture.2008.10.022

    Article  Google Scholar 

  179. Wang, Y. B. (2007). Effect of probiotics on growth performance and digestive enzyme activity of the shrimp Penaeus vannamei. Aquaculture. https://doi.org/10.1016/j.aquaculture.2007.05.035

    Article  Google Scholar 

  180. Wang, Y. B., Xu, Z. R., & Xia, M. S. (2005). The effectiveness of commercial probiotics in northern white shrimp Penaeus vannamei ponds. Fisheries Science. https://doi.org/10.1111/j.1444-2906.2005.01061.x

    Article  Google Scholar 

  181. Wanja, D. W., Mbuthia, P. G., Waruiru, R. M., Bebora, L. C., Ngowi, H. A., & Nyaga, P. N. (2020). Antibiotic and disinfectant susceptibility patterns of bacteria isolated from farmed fish in Kirinyaga County Kenya. International Journal of Microbiology. https://doi.org/10.1155/2020/8897338

    Article  PubMed  PubMed Central  Google Scholar 

  182. Waters, C. M., & Bassler, B. L. (2005). QUORUM SENSING: Cell-to-cell communication in bacteria. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.21.012704.131001

    Article  PubMed  Google Scholar 

  183. Weimer, P. J. (2015). Redundancy, resilience, and host specificity of the ruminal microbiota: Implications for engineering improved ruminal fermentations. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2015.00296

    Article  PubMed  PubMed Central  Google Scholar 

  184. Wideman, R. F., Hamal, K. R., Stark, J. M., Blankenship, J., Lester, H., Mitchell, K. N., Lorenzoni, G., & Pevzner, I. (2012). A wire-flooring model 1 for inducing lameness in broilers: Evaluation of probiotics as a prophylactic treatment. Poultry Science, 91, 870–883. https://doi.org/10.3382/ps.2011-01907

    Article  PubMed  Google Scholar 

  185. Wlodarska, M., Willing, B., Keeney, K. M., Menendez, A., Bergstrom, K. S., Gill, N., Russell, S. L., Vallance, B. A., & Finlay, B. B. (2011). Antibiotic treatment alters the colonic mucus layer and predisposes the host to exacerbated Citrobacter rodentium-induced colitis. Infection and Immunity. https://doi.org/10.1128/IAI.01104-10

    Article  PubMed  PubMed Central  Google Scholar 

  186. Wu, R., Shen, J., Tian, D., Yu, J., He, T., Yi, J., & Li, Y. (2020). A potential alternative to traditional antibiotics in aquaculture: Yeast glycoprotein exhibits antimicrobial effect in vivo and in vitro on Aeromonas caviae isolated from Carassius auratus gibelio. Vetnary Medcine Science. https://doi.org/10.1002/vms3.253

    Article  Google Scholar 

  187. Xiang, Q., Wang, C., Zhang, H., Lai, W., Wei, H., & Peng, J. (2019). Effects of different probiotics on laying performance, egg quality, oxidative status, and gut health in laying hens. Animals. https://doi.org/10.3390/ani9121110

    Article  PubMed  PubMed Central  Google Scholar 

  188. Xu, J., Li, Y., Yang, Z., Li, C., Liang, H., Wu, Z., & Pu, W. (2018). Yeast probiotics shape the gut microbiome and improve the health of early-weaned piglets. Frontiers in Microbiology, 9, 1–11. https://doi.org/10.3389/fmicb.2018.02011

    Article  Google Scholar 

  189. Xu, T., Chen, Y., Yu, L., Wang, J., Huang, M., & Zhu, N. (2020). Effects of Lactobacillus plantarum on intestinal integrity and immune responses of egg-laying chickens infected with Clostridium perfringens under the free-range or the specific pathogen free environment. BMC Veterinary Research. https://doi.org/10.1186/s12917-020-2264-3

    Article  PubMed  PubMed Central  Google Scholar 

  190. Yang, Y., Latorre, J. D., Khatri, B., Kwon, Y. M., Kong, B. W., Teague, K. D., Graham, L. E., Wolfenden, A. D., Mahaffey, B. D., Baxter, M., Hernandez-Velasco, X., Merino-Guzman, R., Hargis, B. M., & Tellez, G. (2018). Characterization and evaluation of lactic acid bacteria candidates for intestinal epithelial permeability and Salmonella typhimurium colonization in neonatal Turkey poults. Poultry Science, 97, 515–521. https://doi.org/10.3382/ps/pex311

    CAS  Article  PubMed  Google Scholar 

  191. Yildirim, Z., & Johnson, M. G. (1998). Characterization and antimicrobial spectrum of bifidocin B, a bacteriocin produced by Bifidobacterium bifidum NCFB 1454. Journal of Food Protection. https://doi.org/10.4315/0362-028X-61.1.47

    Article  PubMed  Google Scholar 

  192. Yousefi, M., & Karkoodi, K. (2007). Effect of probiotic thepax® and Saccharomyces cerevisiae supplementation on performance and egg quality of laying hens. International Journal of Poultry Science. https://doi.org/10.3923/ijps.2007.52.54

    Article  Google Scholar 

  193. Yulianto, A.B., Lokapirnasari, W.P., Najwan, R., Wardhani, H.C.P., Rahman, N.F.N., Huda, K., Ulfah, N., 2020. Influence of lactobacillus casei WB 315 and crude fish oil (CFO) on growth performance, EPA, DHA, HDL, LDL, cholesterol of meat broiler chickens. Iran. J. Microbiol. DOI: https://doi.org/10.18502/ijm.v12i2.2620

  194. Zhang, C. N., Zhang, J. L., Guan, W. C., Zhang, X. F., Guan, S. H., Zeng, Q. H., Cheng, G. F., & Cui, W. (2017). Effects of Lactobacillus delbrueckii on immune response, disease resistance against Aeromonas hydrophila, antioxidant capability and growth performance of Cyprinus carpio Huanghe var. Fish & Shellfish Immunology. https://doi.org/10.1016/j.fsi.2017.07.012

    Article  Google Scholar 

  195. Zhang, H., Wang, H., Shepherd, M., Wen, K., Li, G., Yang, X., Kocher, J., Giri-Rachman, E., Dickerman, A., Settlage, R., & Yuan, L. (2014). Probiotics and virulent human rotavirus modulate the transplanted human gut microbiota in gnotobiotic pigs. Gut Pathology. https://doi.org/10.1186/s13099-014-0039-8

    Article  Google Scholar 

  196. Zhang, J. L., Xie, Q. M., Ji, J., Yang, W. H., Wu, Y. B., Li, C., Ma, J. Y., & Bi, Y. Z. (2012). Different combinations of probiotics improve the production performance, egg quality, and immune response of layer hens. Poultry Science, 91, 2755–2760. https://doi.org/10.3382/ps.2012-02339

    CAS  Article  PubMed  Google Scholar 

  197. Zhang, L., Zhang, R., Jia, H., Zhu, Z., Li, H., & Ma, Y. (2021). Supplementation of probiotics in water beneficial growth performance, carcass traits, immune function, and antioxidant capacity in broiler chickens. Open Life Science, 16, 311–322. https://doi.org/10.1515/biol-2021-0031

    CAS  Article  Google Scholar 

  198. Zhang, Z. F., & Kim, I. H. (2014). Effects of multistrain probiotics on growth performance, apparent ileal nutrient digestibility, blood characteristics, cecal microbial shedding, and excreta odor contents in broilers. Poultry Science. https://doi.org/10.3382/ps.2013-03314

    Article  PubMed  PubMed Central  Google Scholar 

  199. Zhao, X., Guo, Y., Guo, S., & Tan, J. (2013). Effects of Clostridium butyricum and Enterococcus faecium on growth performance, lipid metabolism, and cecal microbiota of broiler chickens. Applied Microbiology and Biotechnology, 97, 6477–6488. https://doi.org/10.1007/s00253-013-4970-2

    CAS  Article  PubMed  Google Scholar 

  200. Zhitnitsky, D., Rose, J., & Lewinson, O. (2017). The highly synergistic, broad spectrum, antibacterial activity of organic acids and transition metals. Science Reports. https://doi.org/10.1038/srep44554

    Article  Google Scholar 

  201. Zulkifli, I., Abdullah, N., & Mohd. Azrin, N., Ho, Y.W.,. (2000). Growth performance and immune response of two commercial broiler strains fed diets containing Lactobacillus cultures and oxytetracycline under heat stress conditions. British Poultry Science. https://doi.org/10.1080/713654979

    Article  PubMed  Google Scholar 

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Acknowledgements

The author would like to thank the Genetics and Molecular Biology Research Group of the Department of Zoology, University of Dhaka, Bangladesh.

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Anee, I.J., Alam, S., Begum, R.A. et al. The role of probiotics on animal health and nutrition. JoBAZ 82, 52 (2021). https://doi.org/10.1186/s41936-021-00250-x

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Keywords

  • Probiotic
  • Antibiotic
  • Poultry
  • Ruminant
  • Aquaculture
  • Immunity
  • Animal health