Abdel Hameed, T. F. (2004). Light and electron microscopic studies on the effect of orally administered formalin on liver and kidney of guinea pig. Journal of the Egyptian-German Society of Zoology, 45, 203–224.
Google Scholar
Abdul-Hamid, M., & Moustafa, N. A. (2005). Effect of ethanol administration on the liver and kidney of rat newborns at different conditions. Journal of the Egyptian-German Society of Zoology, 24, 267–294.
Google Scholar
AL-Mosaibih, M. A. (2013). Effects of monosodium glutamate and acrylamide on the liver tissue of adult Wistar rats. Life Science Journal, 10(2s),35-42.
Alvarez-Fischer, D., Noelker, C., Vulinovic´, F., Grunewald, A., Chevarin, C., Klein, C., … Hartmann, A. (2013). Bee venom and its component apamin as neuroprotective agents in Parkinson disease in mouse model. PLoS One, 8(4), e61700.
Article
CAS
Google Scholar
Asha, S., Renu, S., & Jyotsna, J. (2008). Biochemical changes in the liver of Swiss albino mice orally exposed to acrylamide. Maejo International Journal of Science and Technology, 2(03), 542–550.
Google Scholar
Ashoor, S. H., & Zent, J. B. (1984). Maillard browning of common amino acids and sugars. Journal of Food Science, 49, 1206–1207.
Article
CAS
Google Scholar
Awad, M. E., Abdel-Rahman, M. S., & Hassan, S. A. (1998). Acrylamide toxicity in isolated rat hepatocytes. Toxicology In Vitro, 12, 699–704.
Article
CAS
Google Scholar
Barham, D., & Trinder, P. (1972). Enzymatic colorimetric methods for determination of uric acid in serum plasma and urine. The Analyst, 97, 142–146.
Article
CAS
Google Scholar
Bekheeta, S. H. M., Awadallaa, E. A., Salmanb, M. M., & Hassan, M. K. (2013). Prevention of hepatic and renal toxicity with bradykinin potentiating factor (BPF) isolated from Egyptian scorpion venom (Buthus occitanus) in gentamicin treated rats. Tissue and Cell, 45, 89–94.
Article
Google Scholar
Bekheeta, S. H. M., Awadallaa, E. A., Salmanb, M. M., & Hassana, M. K. (2011). Bradykinin potentiating factor isolated from Buthus occitanus venom has a protective effect against cadmium-induced rat liver and kidney damage. Tissue and Cell, 43, 337–343.
Article
Google Scholar
Benziane, B., Bouras, D., Mezaini, A., Belhadri, A., & Benali, M. (2018). Effect of oral exposure to acrylamide on biochemical and hematologic parameters in Wistar rats. Drug and Chemical Toxicology, 28, 1–10.
Article
Google Scholar
Brown, G. C., & Borutaite, V. (2008). Regulation of apoptosis by the redox state of cytochrome c. Biochimica et Biophysica Acta, 1777(7–8), 877–881.
Article
CAS
Google Scholar
Buchlowalow, B. I., & Bocker, W. (2010). Immunohistochemistry. Basics and methods. Berlin, Heidelberg: Springer Verlag.
Book
Google Scholar
Camargo, A., Ianzer, D., Guerreiro, J. R., & Serrano, S. M. (2012). Bradykinin-potentiating peptides: Beyond captopril. Toxicon, 59, 516–523.
Article
CAS
Google Scholar
Chaney, A. L., Marbach, C. P., & Fawectt, J. K. (1962). A colorimeteric method for determination of blood urea concentration. Journal of Clinical Chemistry, 8, 130–133.
CAS
PubMed
Google Scholar
Chen, J., & Lariviere, W. R. (2010). The nociceptive and anti-nociceptive effects of bee venom injection and therapy: A double-edged sword. Progress in Neurobiology, 92, 151–183.
Article
CAS
Google Scholar
Cheville, N. F. (2009). Ultrastructural pathology: The comparative cellular basis of disease. (2nd ed., ). Wiley-Blackwell A john Wiley of Sons, Inc USA. 23, 154–178.
Chinoy, N. J., & Memon, M. R. (2001). Beneficial effects of some vitamins and calcium on fluoride and aluminium toxicity of gastrocnemius muscle and liver of male mice. Fluoride, 34, 21–33.
CAS
Google Scholar
Danneels, E. L., Van Vaerenbergh, M., Debyser, G., Devreese, B., & de Graaf, D. C. (2015). Honeybee venom proteome profile of queens and winter bees as determined by a mass spectrometric approach. Toxins, 7, 4468–4483.
Article
CAS
Google Scholar
Darwish, S. F., El-Bakly, W. M., Arafa, H. M., & El-Demerdash, E. (2013). Targeting TNF-alpha and NF-kappa B activation by bee venom: Role in suppressing adjuvant induced arthritis and methotrexate hepatotoxicity in rats. PLoS One, 8, e79284.
Article
Google Scholar
Davis, L. N., Durkin, P. R., Howard, P. H., & Saxena, J. (1976). Investigation of selected potential environmental contaminants: Acrylamide, EPA Technical Report, PB-257 (vol. 704, pp. 1–147).
Google Scholar
Dearfield, K. L., Douglas, G. R., Ehling, U. H., Moore, M. M., Sega, G. A., & Brusick, D. J. (1995). Acrylamide: A review of its genotoxicity and an assessment of heritable genetic risk. Mutation Research, 330, 71–99.
Article
CAS
Google Scholar
Dortaj, H., Anvari, M., Yadegari, M., Sharifabad, M. H., & Sarcheshmeh, A. A. (2017). Stereological survey of the effect of vitamin C on neonatal rat kidney tissue treated with acrylamide. Modern Medical Laboratory Journal, 1(2), 42–49.
Article
Google Scholar
Doumas, B. T., & Biggs, H. G. (1976). Standard method of clinical chemistry, (p. 175). New York: Acad. Press.
Google Scholar
Drury, R., & Wallington, E. (1976). Carleton’s histological technique, (pp. 48–58). London: Oxford University Press.
Google Scholar
Dybing, E., & Sanner, T. (2003). Risk assessment of acrylamide in foods. Toxicological Sciences, 75, 7–15.
Article
CAS
Google Scholar
El-Saadani, M. A. (2004). A scorpion venom peptide fraction induced prostaglandin biosynthesis in guinea pig kidneys: Incorporation of 14C-linoleic acid. The Biochemist, 135(1), 109–116.
CAS
Google Scholar
Elshater, A. A., Mohi Eldin, M. M., Salman, M. M. A., & Kasem, N. R. A. (2014). The curative effect of bee venom and propolis on oxidative stress induced by γ-irradiation on blood and tissues of rats. Egyptian Academic Journal of Biological Sciences, 6(1), 53–69.
Google Scholar
Eman, M. A. E., & Amany, Y. M. R. (2008). Some studies on acrylamide intoxication in male albino rats. Egyptian Journal of Comparative Pathology and Clinical Pathology, 21, 222–245.
Google Scholar
Eriksson, S. (2005). Acrylamide in food products: Identification, formation and analytical methodology, PhD thesis, Department of Environmental Chemistry. Stockholm: Stockholm University.
Google Scholar
Ferreira, S. H. (1965). A bradykinin-potentiating factor (Bpf) present in the venom of Bothrops jararaca. British Journal of Pharmacology, 24, 163–169.
CAS
Google Scholar
Ferreira, S. H., Greene, L. H., Alabaster, V. A., Bakhle, Y. S., & Vane, J. R. (1970). Activity of various fractions of bradykinin potentiating factor against angiotensin I converting enzyme. Nature, 225, 379–380.
Article
CAS
Google Scholar
Gajski, G., & Garaj-Vrhovac, V. (2009). Radioprotective effects of honey bee venom (Apis mellifera) against 915-MHz microwave radiation induced DNA damage in Wistar rat lymphocytes: In vitro study. International Journal of Toxicology, 28(2), 88–98.
Article
CAS
Google Scholar
Gamboa da Costa, G., Churchwell, M. I., Hamilton, L. P., von Tungeln, L. S., Beland, F. A., Marques, M. M., & Doerge, D. R. (2003). DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice. Chemical Research in Toxicology, 16, 1328–1337.
Article
CAS
Google Scholar
Green, D. R. (2005). Apoptotic pathways: Ten minutes to dead. Cell, 121, 671–674.
Article
CAS
Google Scholar
Guo, L. Y., Zhu, J. F., & Wu, X. F. (1999). Cloning of a cDNA encoding a nerve growth factor precursor from the Agkistrodon halys Pallas. Toxicon, 37, 465–470.
Article
CAS
Google Scholar
Hegazi, A. G. (2012). Medical importance of bee products. U. Arı Drg. Kasım Bee J, 12(4), 136–146.
Google Scholar
Husdan, H., & Rapoport, A. (1968). Estimation of creatinine by the Jaffe reaction. A comparison of three methods. Clinical Chemistry, 14(3), 222–238.
CAS
PubMed
Google Scholar
Hyunseong, K., Gihyun, L., Soojin, P., Hwan-Suck, C., Hyojung, L., Jong-Yoon, K., … Hyunsu, B. (2013). Bee venom mitigates cisplatin-induced nephrotoxicity by regulating CD4(+) CD25(+) Foxp3(+) regulatory T cells in mice. Evidence-based Complementary and Alternative Medicine, 2013, 1–10.
IARC (International Agency for Research on Cancer) (1994). Some industrial chemicals, IARC Monogr. Eval. Carcinog. Risk Chem. Hum, 60, 389–433.
Google Scholar
Jain, R. K. (2003). Molecular regulation of vessel maturation. Nature Medicine, 9, 685–693.
Article
CAS
Google Scholar
Jang, H. S., Chung, H. S., Ko, E., Shin, J. S., Shin, M. K., Hong, M. C., et al. (2009). Microarray analysis of gene expression profiles in response to treatment with bee venom in lipopolysaccharide activated RAW 264.7 cells. Journal of Ethnopharmacology, 121, 213–220.
Article
CAS
Google Scholar
Javad, B., Adeleh, D., & Ali, A. S. (2014). Honey bee venom decreases the complications of diabetes by preventing hemoglobin glycation. Journal of Molecular Liquids, 199, 371–375.
Article
Google Scholar
Khalil, W. K. B., Assaf, N., ElShebiney, S. A., & Salem, N. A. (2015). Neuroprotective effects of bee venom acupuncture therapy against rotenone-induced oxidative stress and apoptosis. Neurochemistry International, 80, 79–86.
Article
CAS
Google Scholar
Korshunov, S. S., Krasnikov, B. F., Pereverzev, M. O., & Skulachev, V. P. (1999). The antioxidant functions of cytochrome c. FEBS Letters, 462, 192–198.
Article
CAS
Google Scholar
Lee, K. G., Cho, H. J., Bae, Y. S., Park, K. K., Choe, J. Y., Chung, I. K., et al. (2009). Bee venom suppresses LPS-mediated NO/iNOS induction through inhibition of PKC-alpha expression. Journal of Ethnopharmacology, 123, 15–21.
Article
CAS
Google Scholar
Lewis, R. J., & Garcia, M. L. (2003). Therapeutic potential of venom peptides. Nature Reviews. Drug Discovery, 2, 790–802.
Article
CAS
Google Scholar
Lipps, B. V. (1998). Biological and immunological properties of nerve growth factor from snake venom. Journal of Natural Toxins, 7, 121–130.
CAS
PubMed
Google Scholar
Machado, R. A., Junior, L. G. M., Monteiro, N. K. V., Silva-Júnior, A. A., Portaro, F. C. V., Barbosa, E. G., … Fernandes-Pedrosa, M. (2015). Homology modeling, vasorelaxant and bradykinin-potentiating activities of a novel hypotensin found in the scorpion venom from Tityus stigmurus. Toxicon, 101, 11–18.
Article
CAS
Google Scholar
Mahmood, S. A. F., Amin, K. A. M., & Salih, S. F. M. (2015). Effect of acrylamide on liver and kidneys in albino Wistar rats. International Journal of Current Microbiology and Applied Sciences, 4(5), 434–444.
CAS
Google Scholar
Mansour, M. K., Ibrahim, E. M., El-Kholy, M. M., & El-Madawy, S. A. (2008). Antioxidant and histopathological effect of catechin and neem leaves extract in acrylamide toxicity of rats. Egyptian Journal of Comparative Pathology and Clinical Pathology, 21, 290–313.
Google Scholar
Martin, M. C., Allan, L. A., Lickrish, M., Sampson, C., Morrice, N., & Clarke, P. R. (2005). Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c. The Journal of Biological Chemistry, 280, 15449–15455.
Article
CAS
Google Scholar
Meki, A., & Omar, H. E. (1997). A bradykinin potentiating fraction isolated from the venom of Egyptian scorpion Buthus occitanus induced prostaglandin biosynthesis in female guinea pigs. Comparative Biochemistry and Physiology, 116, 183–189.
Google Scholar
Moustafa, N. A., & Abdul-Hamid, M. (2007). Protective effect of phytic acid against the microscopical changes induced by aflatoxin B1 in the liver and kidney of white rats. Journal of the Egyptian-German Society of Zoology, 53, 1–27.
Google Scholar
Nassar, A. Y., Abu-Sinna, G., & Abdel Rahim, S. (1990). Effect of bradykinin potentiating fraction from venom of the Egyptian scorpion, Buthus occitanus on the ovarian and endometrium of mice. Toxicon, 28, 525–534.
Article
CAS
Google Scholar
Nassar, A. Y., Abu-Sinna, G., Abdel Rahim, S., Soliman, M., & El-Saadani, M. (1992). Bradykinin potentiating fraction isolated from venom of Buthus occitanus promotes spermatogenesis in premature mice. Rec. Advance Toxinol. Research, 2, 119–135.
Google Scholar
Needelman, P., Marshall, G., & Sahel, B. E. (1975). Hormones interactions in the isolated rabbit heart: Synthesis and coronary vasomotor effects of prostaglandins, angiotensin and bradykinin. Circulation Research, 37, 802–808.
Article
Google Scholar
Orśolić, N. (2012). Bee venom in cancer therapy. Cancer Metastasis Reviews, 31, 173–194.
Article
Google Scholar
Osman, M. A., Romeilah, R. M., Elgammal, M. H., Ramis, E. S., & Hasan, R. S. (2016). Subchronic toxicity of acrylamide in fried rice and preventive effect of grape leaves. Asian Journal of Biochemistry, 11(2), 68–81.
Article
CAS
Google Scholar
Pari, L., & Murugan, P. (2004). Protective role of tetrahydrocurcumin against erythromycin estolate induced hepatotoxicity. Pharmacological Research, 49, 481–486.
Article
CAS
Google Scholar
Park, J. H., Kim, K. H., Kim, S. J., Lee, W. R., Lee, K. G., & Park, K. K. (2010). Bee venom protects hepatocytes from tumor necrosis factor-alpha and actinomycin D. Archives of Pharmacal Research, 33(2), 215–223.
Article
Google Scholar
Pereverzev, M. O., Vygodina, T. V., Konstantinov, A. A., & Skulachev, V. P. (2003). Cytochrome c, an ideal antioxidant. Biochemical Society Transactions, 31, 1312–1315.
Article
CAS
Google Scholar
Rawi, S. M., Marie, M. A., Fahmy, S. S. R., & El-Abied, S. A. (2012). Hazardous effects of acrylamide on immature male and female rats. African Journal of Pharmacy and Pharmacology, 6, 1367–1386.
CAS
Google Scholar
Reitman, S., & Frankel, S. (1957). A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. American Journal of Clinical Pathology, 28(1), 56:63.
Article
Google Scholar
Rice-Evans, C., & Burdon, R. (1993). Free radical-lipid interactions and their pathological consequences. Progress in Lipid Research, 32, 71–110.
Article
CAS
Google Scholar
Roberts, R. A. (1989). Bradykinin receptors: Characterization, distribution and mechanisms of signal transduction. Progress in Growth Factor Research, 1, 237–252.
Article
CAS
Google Scholar
Salman, M.M.A. (1995). Effect of a bradykinin potentiating factor isolated from scorpion venom, Buthus occitanus on burnt skin of Guinea pig in comparison with other drugs. M.Sc. Thesis, Faculty of Science, Ain Shams University.
Google Scholar
Sega, G. A., Valdivia, R. P., Tancongco, C. P., & Brimer, P. (1989). Acrylamide binding to the DNA and protamine of spermiogenic stages in the mouse and its relationship to genetic damage. Mutation Research, 216, 221–230.
Article
CAS
Google Scholar
Seo, S., Jung, W., Lee, S., Choi, C., Shin, B., Kim, E., … Park, S. (2008). Effects of bee venom on cholecystokinin octapeptide Y induced acute pancreatitis in rats. Pancreas, 36(2), 22–29.
Article
Google Scholar
Shelly, (1996). Regina vs. Calder. Transcript records of New Zealand High Court, Christchurch, New Zealand.
Google Scholar
Shrivastava, S., Uthra, C., Salim Reshi, M., Singh, A., Yadav, D., & Shukla, S. (2018). Protective effect of hesperetin against acrylamide induced acute toxicity in rats. Indian The Journal of Experimental Biology,56: 164–170
Siahkoohi, S., Anvari, M., Tafti, M. A., & Sharifabad, M. H. (2014). The effects of vitamin E on the liver integrity of mice fed with acrylamide diet. Iranian Journal of Pathology, 9(2), 89–98.
Google Scholar
Sipes, I. G., & Carter, D. E.(1981). Pharmakinetics of xenobiotics: Acrylamide. NIEHS Contract No. 1- ES-8-2130.
Google Scholar
Smith, E. A., & Oehme, F. W. (1991). Acrylamide and polyacrylamide: A review of production, use, environmental fate and neurotoxicity. Reviews on Environmental Health, 9, 215–228.
Article
CAS
Google Scholar
Son, D. J., Lee, J. W., Lee, Y. H., Song, H. S., Lee, C. K., & Hong, J. T. (2007). Therapeutic application of antiarthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. Pharmacology and Therapeutics, 115(2), 246–270.
Article
CAS
Google Scholar
Sonveaux, P. (2008). Provascular strategy: Targeting functional adaptations of mature blood vessels in tumors to selectively influence the tumor vascular reactivity and improve cancer treatment. Radiotherapy and Oncology, 86, 300–313.
Article
Google Scholar
Susan, C. J., Rodney, W. S., Wojciechl, K., Bahman, A., & Timothy, R. F. (2003). Acrylamide: A comparison of metabolism and hemoghobin adducts in rodents following, dermal, intraperitoneal, oral, or inhalation exposure. Toxicological Sciences, 75, 260–270.
Article
Google Scholar
Törnqvist, M. (2005). Acrylamide in food: The discovery and its implications. In Chemistry and Safety of Acrylamide in Food, See Friedman Mottram, (pp. 1–19).
Google Scholar
Totani, N., Yawata, M., Ojiri, Y., & Fujioka, Y. (2007). Effects of trace acrylamide intake in Wistar rats. Journal of Oleo Science, 56, 501–506.
Article
CAS
Google Scholar
Tu, W. C., Wu, C. C., Hsieh, H. L., Chen, C. Y., & Hsu, S. L. (2008). Honeybee venom induces calcium dependent but caspase-independent apoptotic cell death in human melanoma A2058 cells. Toxicon, 52, 318–329.
Article
CAS
Google Scholar
Twiddy, D., Brown, D. G., Adrain, C., Jukes, R., Martin, S. J., Cohen, G. M., … Cain, K. (2004). Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase- 9 apoptosome complex. The Journal of Biological Chemistry, 279, 19665–19682.
Article
CAS
Google Scholar
Ty, R. W., Friedman, M. A., Losco, P. E., & Ross, W. P. (2000). Rat two-generation reproduction and dominant lethal study of acrylamide in drinking water. Reproductive Toxicology, 14, 385–401.
Article
Google Scholar
Verano-Braga, T., Figueiredo-Rezende, F., Melo, M. N., Lautner, R. Q., Gomes, E. R. M., Mata-Machado, L. T., … Pimenta, A. M. C. (2010). Structure-function studies of Tityus serrulatus Hypotensin-I (TsHpt-I): A new agonist of B(2) kinin receptor. Toxicon, 56, 1162–1171.
Article
CAS
Google Scholar
Wang, Z. B., Li, M., Zhao, Y., & Xu, J. X. (2003). Cytochrome C is a hydrogen peroxide scavenger in mitochondria. Protein and Peptide Letters, 10, 247–253.
Article
CAS
Google Scholar
WHO (World Health Organization) (2005). Summary report of the sixty-fourth meeting of the joint FAO/WHO expert committee on food additive (JECFA), (pp. 1–47). Washington, DC: Rome, Italy: The ILSI Press International Life Sciences Institute.
Google Scholar
Yoon, M., & Lee, D. (2013). Investigation of the neuroprotective effects of bee-venom acupuncture in a mouse model of Parkinson’s disease by using immunohistochemistry and In−vivo 1H magnetic resonance spectroscopy at 9.4 T. Journal Korean Physical Society, 62(2), 320–327.
Article
CAS
Google Scholar
Yousef, M. I., & El-Demerdash, F. M. (2006). Acrylamide-induced oxidative stress and biochemical perturbations in rats. Toxicology, 219, 133–141.
Article
CAS
Google Scholar